U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    Pfkfb2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24640, updated on 9-Dec-2024

    Summary

    Official Symbol
    Pfkfb2provided by RGD
    Official Full Name
    6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2provided by RGD
    Primary source
    RGD:3309
    See related
    EnsemblRapid:ENSRNOG00000004162 AllianceGenome:RGD:3309
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RH2K; PFK-2
    Summary
    Enables fructose-2,6-bisphosphate 2-phosphatase activity and kinase binding activity. Involved in several processes, including monocarboxylic acid metabolic process; positive regulation of glucokinase activity; and positive regulation of insulin secretion. Predicted to be located in nucleoplasm. Predicted to be active in cytosol. Orthologous to human PFKFB2 (6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 122.2), Lung (RPKM 90.4) and 9 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Pfkfb2 in Genome Data Viewer
    Location:
    13q13
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (44683499..44727135, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (42147473..42174699, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (47413453..47440682, complement)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene complement component 4 binding protein, alpha Neighboring gene LSM6 homolog, U6 small nuclear RNA and mRNA degradation associated like 1 Neighboring gene complement component 4 binding protein, beta Neighboring gene YOD1 deubiquitinase Neighboring gene similar to human chromosome 1 open reading frame 116

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    is_active_in cytosol  
    located_in nucleoplasm  
    located_in nucleoplasm  

    General protein information

    Preferred Names
    6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2
    Names
    6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 (heart)
    6PF-2-K/Fru-2,6-P2ASE heart-type isozyme
    6PF-2-K/Fru-2,6-P2ase 2
    PFK-2/FBPase-2
    PFK/FBPase 2
    fructose 6-phosphate 2-kinase/fructose 2,6-bisphosphatase
    NP_001029136.1
    NP_001029137.1
    NP_536725.2
    XP_006249768.1
    XP_006249769.1
    XP_006249770.1
    XP_006249771.1
    XP_006249772.1
    XP_008767647.1
    XP_038946265.1
    XP_038946266.1
    XP_038946268.1
    XP_038946271.1
    XP_063128095.1
    XP_063128096.1
    XP_063128097.1
    XP_063128099.1
    XP_063128100.1
    XP_063128101.1
    XP_063128102.1
    XP_063128103.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033964.2NP_001029136.1  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 isoform b

      See identical proteins and their annotated locations for NP_001029136.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' end of the coding sequence compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/TrEMBL
      A6IBZ3, R9PXY6
      Related
      ENSRNOP00000082431.1, ENSRNOT00000117528.2
      Conserved Domains (3) summary
      pfam00300
      Location:255438
      His_Phos_1; Histidine phosphatase superfamily (branch 1)
      pfam01591
      Location:29252
      6PF2K; 6-phosphofructo-2-kinase
      pfam13671
      Location:43198
      AAA_33; AAA domain
    2. NM_001033965.2NP_001029137.1  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 isoform a

      See identical proteins and their annotated locations for NP_001029137.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/Swiss-Prot
      Q64297, Q9JHL5, Q9JJH4, Q9JJH5
      UniProtKB/TrEMBL
      A0A8I6GKS2, A6IBZ4
      Related
      ENSRNOP00000005729.3, ENSRNOT00000005729.7
      Conserved Domains (3) summary
      pfam00300
      Location:255438
      His_Phos_1; Histidine phosphatase superfamily (branch 1)
      pfam01591
      Location:29252
      6PF2K; 6-phosphofructo-2-kinase
      pfam13671
      Location:43198
      AAA_33; AAA domain
    3. NM_001429487.1NP_001416416.1  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/TrEMBL
      A6IBZ8, R9PXY6
    4. NM_001429488.1NP_001416417.1  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 isoform 5

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/TrEMBL
      R9PXY6
    5. NM_001429489.1NP_001416418.1  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 isoform c

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/TrEMBL
      A6IBZ2, R9PXY6
    6. NM_001429490.1NP_001416419.1  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 isoform c

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/TrEMBL
      A6IBZ2, R9PXY6
    7. NM_001429491.1NP_001416420.1  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 isoform c

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/TrEMBL
      A6IBZ2, R9PXY6
    8. NM_001429492.1NP_001416421.1  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 isoform 6

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/TrEMBL
      A0A8I6GKS2
    9. NM_001429493.1NP_001416422.1  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 isoform 6

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/TrEMBL
      A0A8I6GKS2
    10. NM_080477.3NP_536725.2  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 isoform c

      See identical proteins and their annotated locations for NP_536725.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks two alternate in-frame exons in the 3' end of the coding sequence compared to variant 1. The resulting isoform (c) has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      BE113134, DY312091, L27084
      UniProtKB/TrEMBL
      A6IBZ2, R9PXY6
      Related
      ENSRNOP00000030819.4, ENSRNOT00000037679.8
      Conserved Domains (3) summary
      pfam00300
      Location:255438
      His_Phos_1; Histidine phosphatase superfamily (branch 1)
      pfam01591
      Location:29252
      6PF2K; 6-phosphofructo-2-kinase
      pfam13671
      Location:43198
      AAA_33; AAA domain

    RNA

    1. NR_190740.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      44683499..44727135 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063272027.1XP_063128097.1  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 isoform X3

      UniProtKB/TrEMBL
      R9PXY6
    2. XM_039090338.2XP_038946266.1  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 isoform X4

      UniProtKB/TrEMBL
      A0A8I6GKS2
      Conserved Domains (2) summary
      pfam00300
      Location:266432
      His_Phos_1; Histidine phosphatase superfamily (branch 1)
      pfam01591
      Location:44263
      6PF2K; 6-phosphofructo-2-kinase
    3. XM_006249709.5XP_006249771.1  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 isoform X6

      Conserved Domains (3) summary
      pfam00300
      Location:255438
      His_Phos_1; Histidine phosphatase superfamily (branch 1)
      pfam01591
      Location:29252
      6PF2K; 6-phosphofructo-2-kinase
      pfam13671
      Location:43198
      AAA_33; AAA domain
    4. XM_063272031.1XP_063128101.1  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 isoform X7

    5. XM_063272030.1XP_063128100.1  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 isoform X6

      UniProtKB/TrEMBL
      A6IBZ2, R9PXY6
    6. XM_063272026.1XP_063128096.1  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 isoform X2

      UniProtKB/TrEMBL
      A6IBZ8, R9PXY6
    7. XM_006249708.2XP_006249770.1  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 isoform X2

      See identical proteins and their annotated locations for XP_006249770.1

      UniProtKB/TrEMBL
      A6IBZ8, R9PXY6
      Related
      ENSRNOP00000044027.4, ENSRNOT00000050859.6
      Conserved Domains (3) summary
      pfam00300
      Location:255438
      His_Phos_1; Histidine phosphatase superfamily (branch 1)
      pfam01591
      Location:29252
      6PF2K; 6-phosphofructo-2-kinase
      pfam13671
      Location:43198
      AAA_33; AAA domain
    8. XM_063272029.1XP_063128099.1  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 isoform X5

      UniProtKB/TrEMBL
      R9PXY6
    9. XM_039090337.2XP_038946265.1  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 isoform X1

      UniProtKB/TrEMBL
      R9PXY6
      Related
      ENSRNOP00000060044.4, ENSRNOT00000067445.5
      Conserved Domains (2) summary
      pfam00300
      Location:266432
      His_Phos_1; Histidine phosphatase superfamily (branch 1)
      pfam01591
      Location:44263
      6PF2K; 6-phosphofructo-2-kinase
    10. XM_006249707.5XP_006249769.1  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 isoform X2

      Conserved Domains (3) summary
      pfam00300
      Location:255438
      His_Phos_1; Histidine phosphatase superfamily (branch 1)
      pfam01591
      Location:29252
      6PF2K; 6-phosphofructo-2-kinase
      pfam13671
      Location:43198
      AAA_33; AAA domain
    11. XM_006249706.5XP_006249768.1  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 isoform X2

      See identical proteins and their annotated locations for XP_006249768.1

      UniProtKB/TrEMBL
      A6IBZ8, R9PXY6
      Conserved Domains (3) summary
      pfam00300
      Location:255438
      His_Phos_1; Histidine phosphatase superfamily (branch 1)
      pfam01591
      Location:29252
      6PF2K; 6-phosphofructo-2-kinase
      pfam13671
      Location:43198
      AAA_33; AAA domain
    12. XM_008769425.4XP_008767647.1  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 isoform X5

      Conserved Domains (3) summary
      pfam00300
      Location:219402
      His_Phos_1; Histidine phosphatase superfamily (branch 1)
      pfam01591
      Location:1216
      6PF2K; 6-phosphofructo-2-kinase
      pfam13671
      Location:7162
      AAA_33; AAA domain
    13. XM_063272025.1XP_063128095.1  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 isoform X2

      UniProtKB/TrEMBL
      A6IBZ8, R9PXY6
    14. XM_063272032.1XP_063128102.1  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 isoform X10

      UniProtKB/TrEMBL
      C9DRP5
    15. XM_039090340.1XP_038946268.1  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 isoform X9

      Conserved Domains (2) summary
      pfam00300
      Location:114280
      His_Phos_1; Histidine phosphatase superfamily (branch 1)
      cl17190
      Location:1111
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
    16. XM_006249710.2XP_006249772.1  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 isoform X8

      See identical proteins and their annotated locations for XP_006249772.1

      UniProtKB/TrEMBL
      C9DRP6
      Conserved Domains (2) summary
      pfam00300
      Location:154337
      His_Phos_1; Histidine phosphatase superfamily (branch 1)
      cl17190
      Location:1151
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
    17. XM_063272033.1XP_063128103.1  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 isoform X10

      UniProtKB/TrEMBL
      C9DRP5
    18. XM_039090343.2XP_038946271.1  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 isoform X11

      Conserved Domains (2) summary
      pfam01591
      Location:44263
      6PF2K; 6-phosphofructo-2-kinase
      cl11399
      Location:265294
      HP; Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction
    Loading
    External link. Please review our privacy policy.