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    Naaa N-acylethanolamine acid amidase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 497009, updated on 9-Dec-2024

    Summary

    Official Symbol
    Naaaprovided by RGD
    Official Full Name
    N-acylethanolamine acid amidaseprovided by RGD
    Primary source
    RGD:1307267
    See related
    EnsemblRapid:ENSRNOG00000002273 AllianceGenome:RGD:1307267
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Asahl
    Summary
    Enables N-(long-chain-acyl)ethanolamine deacylase activity. Involved in N-acylethanolamine metabolic process. Predicted to be located in lysosome and membrane. Orthologous to human NAAA (N-acylethanolamine acid amidase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 459.9), Spleen (RPKM 127.0) and 7 other tissues See more
    Orthologs
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    Genomic context

    See Naaa in Genome Data Viewer
    Location:
    14p22
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (16061599..16080703)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (15777306..15796411)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (17283262..17302364)

    Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene C-X-C motif chemokine ligand 9 Neighboring gene U6atac minor spliceosomal RNA Neighboring gene SDA1 domain containing 1 Neighboring gene protein phosphatase with EF-hand domain 2 Neighboring gene uncharacterized LOC120096576 Neighboring gene endotoxic shock protective protein U9-ORF-like

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Clone Names

    • MGC124515

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in N-acylethanolamine metabolic process PubMed 
    involved_in N-acylethanolamine metabolic process  
    involved_in N-acylethanolamine metabolic process  
    involved_in N-acylphosphatidylethanolamine metabolic process  
    involved_in N-acylphosphatidylethanolamine metabolic process  
    involved_in fatty acid metabolic process  
    involved_in fatty acid metabolic process  
    involved_in fatty acid metabolic process  
    involved_in lipid catabolic process  
    involved_in sphingosine metabolic process  
    involved_in sphingosine metabolic process  
    Component Evidence Code Pubs
    located_in cytoplasm  
    located_in lysosome  
    located_in lysosome  
    located_in membrane  
    located_in membrane  

    General protein information

    Preferred Names
    N-acylethanolamine-hydrolyzing acid amidase
    Names
    ASAH-like protein
    acylsphingosine deacylase NAAA
    NP_001010967.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001010967.2NP_001010967.1  N-acylethanolamine-hydrolyzing acid amidase precursor

      See identical proteins and their annotated locations for NP_001010967.1

      Status: PROVISIONAL

      Source sequence(s)
      BC105771
      UniProtKB/Swiss-Prot
      Q3KRD3, Q5KTC7
      UniProtKB/TrEMBL
      A6KK97
      Related
      ENSRNOP00000003102.5, ENSRNOT00000003102.8
      Conserved Domains (2) summary
      cd01903
      Location:122351
      Ntn_AC_NAAA; AC_NAAA This conserved domain includes two closely related proteins, acid ceramidase (AC, also known as N-acylsphingosine amidohydrolase), and N-acylethanolamine-hydrolyzing acid amidase (NAAA). AC catalyzes the hydrolysis of ceramide to sphingosine and ...
      pfam15508
      Location:36126
      NAAA-beta; beta subunit of N-acylethanolamine-hydrolyzing acid amidase

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086032.1 Reference GRCr8

      Range
      16061599..16080703
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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