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    Or4e1 olfactory receptor family 4 subfamily E member 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 290055, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Or4e1provided by RGD
    Official Full Name
    olfactory receptor family 4 subfamily E member 2provided by RGD
    Primary source
    RGD:1334197
    See related
    EnsemblRapid:ENSRNOG00000039435 AllianceGenome:RGD:1334197
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Olr1644
    Summary
    Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]
    Expression
    Restricted expression toward (RPKM 12.3) See more
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    Genomic context

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    See Or4e1 in Genome Data Viewer
    Location:
    15p14
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (27673536..27684988, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (25201369..25211302, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (28908132..28917980, complement)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 10 subfamily G member 1 Neighboring gene PEST proteolytic signal containing nuclear protein, pseudogene 2 Neighboring gene olfactory receptor family 4 subfamily E member 5 Neighboring gene uncharacterized LOC102555050 Neighboring gene olfactory receptor family 4 subfamily E member 14 Neighboring gene T cell receptor alpha variable 13-2-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis. Na CH, et al. J Proteome Res, 2012 Sep 7. PMID 22871113, Free PMC Article
    2. Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Gibbs RA, et al. Nature, 2004 Apr 1. PMID 15057822
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables odorant binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables olfactory receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables olfactory receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in detection of chemical stimulus involved in sensory perception of smell IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in detection of chemical stimulus involved in sensory perception of smell IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    olfactory receptor Olr1644
    Names
    olfactory receptor 1644
    olfactory receptor gene Olr1644

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001000101.1 → NP_001000101.1  olfactory receptor Olr1644

      See identical proteins and their annotated locations for NP_001000101.1

      Status: REVIEWED

      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/TrEMBL
      A6KEI3, D4AE91
      Related
      ENSRNOP00000057172.4, ENSRNOT00000060428.5
      Conserved Domains (2) summary
      pfam00001
      Location:44 → 290
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:34 → 305
      7tm_4; Olfactory receptor

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      27673536..27684988 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006251923.5 → XP_006251985.1  olfactory receptor Olr1644 isoform X1

      See identical proteins and their annotated locations for XP_006251985.1

      UniProtKB/TrEMBL
      D4AE91
      Conserved Domains (2) summary
      pfam00001
      Location:49 → 295
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:39 → 310
      7tm_4; Olfactory receptor

    2. XM_006251922.5 → XP_006251984.1  olfactory receptor Olr1644 isoform X1

      See identical proteins and their annotated locations for XP_006251984.1

      UniProtKB/TrEMBL
      D4AE91
      Conserved Domains (2) summary
      pfam00001
      Location:49 → 295
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:39 → 310
      7tm_4; Olfactory receptor
    Nucleotide Protein Strain
    Heading Accession and Version

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