Spcs1 signal peptidase complex subunit 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Spcs1provided by RGD
Official Full Name: signal peptidase complex subunit 1provided by RGD
Primary source: RGD:1309125
See related: AllianceGenome:RGD:1309125
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1309125
Summary: Predicted to enable ribosome binding activity. Predicted to be involved in several processes, including protein targeting to ER; signal peptide processing; and viral protein processing. Predicted to be located in endoplasmic reticulum membrane. Predicted to be part of signal peptidase complex. Orthologous to human SPCS1 (signal peptidase complex subunit 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 623.3), Kidney (RPKM 536.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 16p16

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	16	NC_086034.1 (6196653..6198221, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	16	NC_051351.1 (6190208..6191776, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	16	NC_005115.4 (7080389..7081957, complement)

Chromosome 16 - NC_086034.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ribosome binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in protein targeting to ER	IBA Inferred from Biological aspect of Ancestor more info
involved_in signal peptide processing	IBA Inferred from Biological aspect of Ancestor more info
involved_in signal peptide processing	ISO Inferred from Sequence Orthology more info
involved_in viral protein processing	ISO Inferred from Sequence Orthology more info
involved_in virion assembly	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
part_of signal peptidase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of signal peptidase complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: signal peptidase complex subunit 1

Names: signal peptidase complex subunit 1 homolog

NP_001124478.1

EC 3.4.-.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001131006.1 → NP_001124478.1 signal peptidase complex subunit 1

Status: VALIDATED

Source sequence(s)

CF976587, CV795143

Conserved Domains (1) summary

pfam06645
Location:12 → 81

SPC12; Microsomal signal peptidase 12 kDa subunit (SPC12)