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    Tssk6 testis-specific serine kinase 6 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 290670, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tssk6provided by RGD
    Official Full Name
    testis-specific serine kinase 6provided by RGD
    Primary source
    RGD:1559764
    See related
    EnsemblRapid:ENSRNOG00000020599 AllianceGenome:RGD:1559764
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1559764
    Summary
    Predicted to enable ATP binding activity; magnesium ion binding activity; and protein serine/threonine kinase activity. Predicted to be involved in peptidyl-serine phosphorylation and sperm DNA condensation. Predicted to be located in axonemal microtubule doublet inner sheath and sperm flagellum. Orthologous to human TSSK6 (testis specific serine kinase 6). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 263.0), Thymus (RPKM 21.1) and 1 other tissue See more
    Orthologs
    human mouse all
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    Genomic context

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    See Tssk6 in Genome Data Viewer
    Location:
    16p14
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (19551757..19559918, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (19523626..19526074, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (21272282..21274756, complement)

    Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene SURP and G patch domain containing 1 Neighboring gene MAU2 sister chromatid cohesion factor Neighboring gene GATA zinc finger domain containing 2A Neighboring gene NADH:ubiquinone oxidoreductase subunit A13 Neighboring gene YjeF N-terminal domain containing 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Heat shock protein 90 functions to stabilize and activate the testis-specific serine/threonine kinases, a family of kinases essential for male fertility. Jha KN, et al. J Biol Chem, 2013 Jun 7. PMID 23599433, Free PMC Article
    2. Identification and characterization of SSTK, a serine/threonine protein kinase essential for male fertility. Spiridonov NA, et al. Mol Cell Biol, 2005 May. PMID 15870294, Free PMC Article
    3. Proteomic characterization of the human sperm nucleus. de Mateo S, et al. Proteomics, 2011 Jul. PMID 21630459
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables magnesium ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in flagellated sperm motility IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in flagellated sperm motility ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in peptidyl-serine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in sperm DNA condensation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in spermatid development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in axonemal microtubule doublet inner sheath IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in axonemal microtubule doublet inner sheath ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in sperm flagellum IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in sperm flagellum ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    testis-specific serine/threonine-protein kinase 6
    NP_001099548.1
    XP_017455525.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106078.1 → NP_001099548.1  testis-specific serine/threonine-protein kinase 6

      See identical proteins and their annotated locations for NP_001099548.1

      Status: PROVISIONAL

      Source sequence(s)
      CH474031
      UniProtKB/TrEMBL
      A6KAA0, D3ZEK4
      Related
      ENSRNOP00000083870.1, ENSRNOT00000115887.2
      Conserved Domains (1) summary
      cd14164
      Location:11 → 267
      STKc_TSSK6-like; Catalytic domain of testis-specific serine/threonine kinase 6 and similar proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086034.1 Reference GRCr8

      Range
      19551757..19559918 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017600036.3 → XP_017455525.1  testis-specific serine/threonine-protein kinase 6 isoform X1

      UniProtKB/TrEMBL
      A6KAA0, D3ZEK4
      Related
      ENSRNOP00000102938.1, ENSRNOT00000122646.1
      Conserved Domains (1) summary
      cd14164
      Location:11 → 267
      STKc_TSSK6-like; Catalytic domain of testis-specific serine/threonine kinase 6 and similar proteins
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
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