Arsb arylsulfatase B [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Arsbprovided by RGD
Official Full Name: arylsulfatase Bprovided by RGD
Primary source: RGD:2158
See related: EnsemblRapid:ENSRNOG00000011150 AllianceGenome:RGD:2158
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables sulfuric ester hydrolase activity. Involved in several processes, including positive regulation of neuron projection development; response to estrogen; and response to methylmercury. Located in cell surface. Used to study mucopolysaccharidosis VI. Human ortholog(s) of this gene implicated in mucopolysaccharidosis VI. Orthologous to human ARSB (arylsulfatase B). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 330.0), Adrenal (RPKM 238.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q12

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (26736395..26895682)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (25002210..25162675)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (23385154..23543028)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH130793 (e-PCR)
- UniSTS:214077

AU049865 (e-PCR)
- UniSTS:146310

RH127520 (e-PCR)
- UniSTS:210830

D16S506 (e-PCR), detects polymorphism
- UniSTS:15295

RH144163 (e-PCR)
- UniSTS:233409

BF413485 (e-PCR)
- UniSTS:248563

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables N-acetylgalactosamine-4-sulfatase activity	ISO Inferred from Sequence Orthology more info
enables N-acetylgalactosamine-4-sulfatase activity	ISS Inferred from Sequence or Structural Similarity more info
enables N-acetylgalactosamine-6-sulfatase activity	ISO Inferred from Sequence Orthology more info
enables arylsulfatase activity	ISO Inferred from Sequence Orthology more info
enables arylsulfatase activity	TAS Traceable Author Statement more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables sulfuric ester hydrolase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within anterior head development	ISO Inferred from Sequence Orthology more info
involved_in autophagy	IDA Inferred from Direct Assay more info	PubMed
involved_in colon epithelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in colon epithelial cell migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in dermatan sulfate catabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron projection development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of epithelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in regulation of epithelial cell migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to estrogen	IDA Inferred from Direct Assay more info	PubMed
involved_in response to methylmercury	IDA Inferred from Direct Assay more info	PubMed
involved_in response to nutrient	IDA Inferred from Direct Assay more info	PubMed
involved_in response to pH	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	ISO Inferred from Sequence Orthology more info
is_active_in lysosome	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: arylsulfatase B

Names: ASB; Arylsulfatase B (MPS VI); G4S; N-acetylgalactosamine-4-sulfatase

NP_254278.1

EC 3.1.6.12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_033443.1 → NP_254278.1 arylsulfatase B precursor

See identical proteins and their annotated locations for NP_254278.1

Status: VALIDATED

Source sequence(s)

AI071950, CF113828, CK482953, D49434

UniProtKB/Swiss-Prot

P50430, Q32KK1

UniProtKB/TrEMBL

A6I4W1, B4F7E2

Related

ENSRNOP00000014860.5, ENSRNOT00000014860.8

Conserved Domains (2) summary

COG3119
Location:36 → 484

AslA; Arylsulfatase A or related enzyme [Inorganic ion transport and metabolism]

cd16029
Location:40 → 483

4-S; N-acetylgalactosamine 4-sulfatase, also called arylsulftase B