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    Manba mannosidase beta [ Rattus norvegicus (Norway rat) ]

    Gene ID: 310864, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Manbaprovided by RGD
    Official Full Name
    mannosidase betaprovided by RGD
    Primary source
    RGD:1305785
    See related
    EnsemblRapid:ENSRNOG00000052247 AllianceGenome:RGD:1305785
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables D-mannose binding activity and beta-mannosidase activity. Predicted to be involved in glycoprotein catabolic process and oligosaccharide catabolic process. Predicted to be located in extracellular space. Predicted to be active in lysosomal lumen. Human ortholog(s) of this gene implicated in beta-mannosidosis. Orthologous to human MANBA (mannosidase beta). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 334.2), Liver (RPKM 104.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Manba in Genome Data Viewer
    Location:
    2q43
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (226583968..226676520)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (223910432..224002988)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (240668213..240760264)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 9 member B1 Neighboring gene CDGSH iron sulfur domain 2 Neighboring gene ubiquitin-conjugating enzyme E2D 3 Neighboring gene U6 spliceosomal RNA Neighboring gene nuclear factor kappa B subunit 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Beta-mannosidosis mice: a model for the human lysosomal storage disease. Zhu M, et al. Hum Mol Genet, 2006 Feb 1. PMID 16377659
    2. The structure of mammalian β-mannosidase provides insight into β-mannosidosis and nystagmus. Gytz H, et al. FEBS J, 2019 Apr. PMID 30552791
    3. A gene (Bmn) controlling beta-mannosidase activity in the mouse is located in the distal part of chromosome 3. Lundin LG. Biochem Genet, 1987 Aug. PMID 3447593
    4. Rat brain contains high levels of mannose-6-phosphorylated glycoproteins including lysosomal enzymes and palmitoyl-protein thioesterase, an enzyme implicated in infantile neuronal lipofuscinosis. Sleat DE, et al. J Biol Chem, 1996 Aug 9. PMID 8702598
    5. Mice lacking mannose 6-phosphate uncovering enzyme activity have a milder phenotype than mice deficient for N-acetylglucosamine-1-phosphotransferase activity. Boonen M, et al. Mol Biol Cell, 2009 Oct. PMID 19710420, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC116230, MGC125196

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables D-mannose binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables beta-mannosidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables beta-mannosidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables beta-mannosidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables hydrolase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in glycoprotein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within glycoprotein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glycoprotein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glycoprotein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in oligosaccharide catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in lysosomal lumen ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    beta-mannosidase
    Names
    lysosomal beta A mannosidase
    mannanase
    mannase
    mannosidase beta A
    mannosidase, beta A, lysosomal
    NP_001026825.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001031655.2 → NP_001026825.1  beta-mannosidase precursor

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/Swiss-Prot
      Q2NKP5, Q4FZV0
      UniProtKB/TrEMBL
      A6HVY3
      Related
      ENSRNOP00000072765.1, ENSRNOT00000087371.3
      Conserved Domains (3) summary
      COG3250
      Location:24 → 694
      LacZ; Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]
      pfam02837
      Location:80 → 136
      Glyco_hydro_2_N; Glycosyl hydrolases family 2, sugar binding domain
      cl23725
      Location:397 → 568
      Glyco_hydro_1; Glycosyl hydrolase family 1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      226583968..226676520
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q4FZV0.1 GenPept UniProtKB/Swiss-Prot:Q4FZV0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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