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    Ddo D-aspartate oxidase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 685325, updated on 4-Jan-2025

    Summary

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    Symbol
    Ddoprovided by RGD
    Full Name
    D-aspartate oxidaseprovided by RGD
    Primary source
    RGD:1595123
    See related
    EnsemblRapid:ENSRNOG00000000582 AllianceGenome:RGD:1595123
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    DASOX; DASPO
    Summary
    Enables D-aspartate oxidase activity and FAD binding activity. Involved in D-amino acid catabolic process. Located in peroxisome. Orthologous to human DDO (D-aspartate oxidase). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Kidney (RPKM 83.9), Muscle (RPKM 37.4) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ddo in Genome Data Viewer
    Location:
    20q12
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (45673486..45693056)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (44090823..44109962)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (48739812..48758958, complement)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene cyclin-dependent kinase 19 Neighboring gene solute carrier family 22 member 16 Neighboring gene methyltransferase like 24 Neighboring gene uncharacterized LOC120098819 Neighboring gene uncharacterized LOC120098955 Neighboring gene cell division cycle 40

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Rat d-aspartate oxidase is more similar to the human enzyme than the mouse enzyme. Katane M, et al. Biochim Biophys Acta Proteins Proteom, 2018 Jul. PMID 29292239
    2. D-aspartate regulates melanocortin formation and function: behavioral alterations in D-aspartate oxidase-deficient mice. Huang AS, et al. J Neurosci, 2006 Mar 8. PMID 16525061, Free PMC Article
    3. Cellular and subcellular distribution of D-aspartate oxidase in human and rat brain. Zaar K, et al. J Comp Neurol, 2002 Aug 26. PMID 12209855
    4. Structural and functional characterization of the human brain D-aspartate oxidase. Setoyama C, et al. J Biochem, 1997 Apr. PMID 9163533
    5. D-aspartate oxidase, a peroxisomal enzyme in liver of rat and man. Van Veldhoven PP, et al. Biochim Biophys Acta, 1991 Jan 23. PMID 1991137

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables D-aspartate oxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables D-aspartate oxidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables D-aspartate oxidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables D-aspartate oxidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables FAD binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables FAD binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables FAD binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in D-amino acid catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in D-amino acid catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in D-amino acid catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in D-amino acid catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in aspartate catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within aspartate metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within grooming behavior ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within hormone metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within insemination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nervous system process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell communication ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in peroxisomal matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in peroxisomal matrix ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in peroxisome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in peroxisome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in peroxisome ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    D-aspartate oxidase
    NP_001102935.1
    XP_017457261.1
    XP_063135577.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109465.2 → NP_001102935.1  D-aspartate oxidase precursor

      See identical proteins and their annotated locations for NP_001102935.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000020
      UniProtKB/Swiss-Prot
      A6KTC0, D3ZDM7
      Related
      ENSRNOP00000000710.3, ENSRNOT00000000710.7
      Conserved Domains (2) summary
      pfam01266
      Location:5 → 324
      DAO; FAD dependent oxidoreductase
      cl21724
      Location:188 → 256
      GAG_Lyase; Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues, ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      45673486..45693056
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017601772.3 → XP_017457261.1  D-aspartate oxidase isoform X1

      UniProtKB/TrEMBL
      A6KTC1

    2. XM_063279507.1 → XP_063135577.1  D-aspartate oxidase isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    D3ZDM7.1 GenPept UniProtKB/Swiss-Prot:D3ZDM7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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