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    Ddrgk1 DDRGK domain containing 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 296162, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ddrgk1provided by RGD
    Official Full Name
    DDRGK domain containing 1provided by RGD
    Primary source
    RGD:1309979
    See related
    EnsemblRapid:ENSRNOG00000021232 AllianceGenome:RGD:1309979
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1309979
    Summary
    Predicted to enable RNA polymerase II-specific DNA-binding transcription factor binding activity; UFM1-modified protein reader activity; and ubiquitin-like protein ligase binding activity. Involved in negative regulation of apoptotic process. Predicted to be located in endoplasmic reticulum and nucleolus. Predicted to be active in endoplasmic reticulum membrane. Orthologous to human DDRGK1 (DDRGK domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 197.5), Kidney (RPKM 186.9) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Ddrgk1 in Genome Data Viewer
    Location:
    3q36
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (138315006..138336691, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (117861916..117882680, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (123195580..123206828, complement)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene U-box domain containing 5 Neighboring gene FAST kinase domains 5 Neighboring gene leucine zipper tumor suppressor family member 3 Neighboring gene inosine triphosphatase Neighboring gene solute carrier family 4 member 11

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Items 1 - 25 of 33
    Process Evidence Code Pubs
    involved_in cartilage development  
    involved_in cartilage development  
    involved_in negative regulation of IRE1-mediated unfolded protein response  
    involved_in negative regulation of IRE1-mediated unfolded protein response  
    involved_in negative regulation of PERK-mediated unfolded protein response  
    involved_in negative regulation of PERK-mediated unfolded protein response  
    involved_in negative regulation of apoptotic process PubMed 
    involved_in negative regulation of gene expression  
    involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process  
    involved_in positive regulation of I-kappaB phosphorylation  
    involved_in positive regulation of NF-kappaB transcription factor activity  
    involved_in positive regulation of cell migration  
    involved_in positive regulation of cell population proliferation  
    involved_in positive regulation of gene expression  
    involved_in positive regulation of metallopeptidase activity  
    involved_in positive regulation of plasma cell differentiation  
    involved_in positive regulation of plasma cell differentiation  
    involved_in positive regulation of proteasomal protein catabolic process  
    involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process  
    involved_in positive regulation of protein localization to endoplasmic reticulum  
    involved_in positive regulation of proteolysis involved in protein catabolic process  
    involved_in positive regulation of reticulophagy  
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in protein K69-linked ufmylation  
    involved_in protein localization to endoplasmic reticulum  
    involved_in protein ufmylation  
    NOT involved_in regulation of insulin secretion involved in cellular response to glucose stimulus PubMed 
    involved_in regulation of intracellular estrogen receptor signaling pathway  
    involved_in regulation of protein stability  
    involved_in rescue of stalled ribosome  
    involved_in response to endoplasmic reticulum stress  
    involved_in reticulophagy  
    involved_in ribosome disassembly  
    Items 1 - 25 of 33
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum  
    located_in endoplasmic reticulum  
    is_active_in endoplasmic reticulum membrane  
    located_in endoplasmic reticulum membrane  
    located_in nucleolus  
    located_in nucleolus  

    General protein information

    Preferred Names
    DDRGK domain-containing protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106512.2NP_001099982.2  DDRGK domain-containing protein 1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A6HQA5, D3ZAS9
      Related
      ENSRNOP00000036810.4, ENSRNOT00000030192.6
    2. NM_001430162.1NP_001417091.1  DDRGK domain-containing protein 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A8I6AKQ6
    3. NM_001430163.1NP_001417092.1  DDRGK domain-containing protein 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A8I6AKQ6

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      138315006..138336691 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039104581.2XP_038960509.1  DDRGK domain-containing protein 1 isoform X1

      Related
      ENSRNOP00000094012.2, ENSRNOT00000109675.2
      Conserved Domains (1) summary
      pfam09756
      Location:140285
      DDRGK; DDRGK domain
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