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    Prss59 protease, serine 59 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 408205, updated on 9-Dec-2024

    Summary

    Official Symbol
    Prss59provided by RGD
    Official Full Name
    protease, serine 59provided by RGD
    Primary source
    RGD:1302947
    See related
    EnsemblRapid:ENSRNOG00000028989 AllianceGenome:RGD:1302947
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Tryx5
    Summary
    Predicted to enable serine-type endopeptidase activity. Predicted to be involved in protein maturation. Predicted to be located in Golgi apparatus. Predicted to be active in extracellular space and secretory granule. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 112.0) See more
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    Genomic context

    See Prss59 in Genome Data Viewer
    Location:
    4q23
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (70730890..70751798, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (69764206..69785111, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (69156269..69164906, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene monooxygenase, DBH-like 2 Neighboring gene T-cell receptor beta chain V region E1-like Neighboring gene serine protease 58 Neighboring gene protease, serine, 3B like 1 Neighboring gene RIKEN cDNA 1810009J06 gene like

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables serine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in protein maturation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in secretory granule IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    protease, serine 59
    Names
    trypsin X5

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001009173.2NP_001009173.1  protease, serine 59 precursor

      See identical proteins and their annotated locations for NP_001009173.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      Q6IE07
      Conserved Domains (2) summary
      pfam00089
      Location:36243
      Trypsin; Trypsin
      cl21584
      Location:36243
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      70730890..70751798 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063286408.1XP_063142478.1  protease, serine 59 isoform X2

    2. XM_063286410.1XP_063142480.1  protease, serine 59 isoform X2

    3. XM_063286409.1XP_063142479.1  protease, serine 59 isoform X2

    4. XM_006236368.5XP_006236430.1  protease, serine 59 isoform X1

      See identical proteins and their annotated locations for XP_006236430.1

      UniProtKB/TrEMBL
      A6IEZ6, F7EZP5
      Related
      ENSRNOP00000041980.4, ENSRNOT00000048779.5
      Conserved Domains (1) summary
      cl21584
      Location:37244
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    5. XM_063286411.1XP_063142481.1  protease, serine 59 isoform X3