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    Gtf2a1l general transcription factor 2A subunit 1 like [ Rattus norvegicus (Norway rat) ]

    Gene ID: 316711, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gtf2a1lprovided by RGD
    Official Full Name
    general transcription factor 2A subunit 1 likeprovided by RGD
    Primary source
    RGD:1308625
    See related
    EnsemblRapid:ENSRNOG00000016703 AllianceGenome:RGD:1308625
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Gtf2a1lf
    Summary
    Predicted to be involved in cognition and transcription by RNA polymerase II. Predicted to be located in cytoplasm and male germ cell nucleus. Predicted to be part of transcription factor TFIIA complex. Orthologous to human GTF2A1L (general transcription factor IIA subunit 1 like). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 295.2) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Gtf2a1l in Genome Data Viewer
    Location:
    6q12
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (11506362..11591622, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (5752814..5834797, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (12412198..12468613)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479270 Neighboring gene luteinizing hormone/choriogonadotropin receptor Neighboring gene pyruvate kinase PKM-like Neighboring gene uncharacterized LOC120103455 Neighboring gene stonin 1 Neighboring gene uncharacterized LOC134479304 Neighboring gene ubiquitin-conjugating enzyme E2S, pseudogene 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Transcription Factor IIA tau is associated with undifferentiated cells and its gene expression is repressed in primary neurons at the chromatin level in vivo. Howe ML, et al. Stem Cells Dev, 2006 Apr. PMID 16646664
    2. Proteolytic cleavage of ALF into alpha- and beta-subunits that form homologous and heterologous complexes with somatic TFIIA and TRF2 in male germ cells. Catena R, et al. FEBS Lett, 2005 Jun 20. PMID 15927180
    3. Analysis of copy number variation in Alzheimer's disease in a cohort of clinically characterized and neuropathologically verified individuals. Swaminathan S, et al. PLoS One, 2012. PMID 23227193, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TFIIA tau is associated with undifferentiated cells during development, yet is down-regulated at the chromatin level upon cellular differentiation.
      Title: Transcription Factor IIA tau is associated with undifferentiated cells and its gene expression is repressed in primary neurons at the chromatin level in vivo.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in cognition ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transcription initiation at RNA polymerase II promoter IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in male germ cell nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of transcription factor TFIIA complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of transcription factor TFIIA complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    TFIIA-alpha and beta-like factor
    Names
    general transcription factor II A, 1-like factor
    general transcription factor IIA, 1-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001012136.1 → NP_001012136.1  TFIIA-alpha and beta-like factor

      See identical proteins and their annotated locations for NP_001012136.1

      Status: PROVISIONAL

      Source sequence(s)
      BC082104
      UniProtKB/TrEMBL
      Q641W8
      Conserved Domains (1) summary
      pfam03153
      Location:10 → 468
      TFIIA; Transcription factor IIA, alpha/beta subunit

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      11506362..11591622 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063262033.1 → XP_063118103.1  TFIIA-alpha and beta-like factor isoform X1

      UniProtKB/TrEMBL
      F7F7R8

    2. XM_063262031.1 → XP_063118101.1  TFIIA-alpha and beta-like factor isoform X1

      UniProtKB/TrEMBL
      F7F7R8

    3. XM_063262034.1 → XP_063118104.1  TFIIA-alpha and beta-like factor isoform X1

      UniProtKB/TrEMBL
      F7F7R8

    4. XM_039112433.2 → XP_038968361.1  TFIIA-alpha and beta-like factor isoform X2

      Related
      ENSRNOP00000102469.1, ENSRNOT00000141705.1
      Conserved Domains (1) summary
      pfam03153
      Location:57 → 483
      TFIIA; Transcription factor IIA, alpha/beta subunit

    5. XM_039112432.2 → XP_038968360.1  TFIIA-alpha and beta-like factor isoform X1

      UniProtKB/TrEMBL
      F7F7R8
      Conserved Domains (1) summary
      pfam03153
      Location:59 → 517
      TFIIA; Transcription factor IIA, alpha/beta subunit

    6. XM_063262032.1 → XP_063118102.1  TFIIA-alpha and beta-like factor isoform X1

      UniProtKB/TrEMBL
      F7F7R8
      Related
      ENSRNOP00000022380.6, ENSRNOT00000022380.8

    7. XM_039112434.2 → XP_038968362.1  TFIIA-alpha and beta-like factor isoform X3

      Conserved Domains (1) summary
      pfam03153
      Location:269 → 348
      TFIIA; Transcription factor IIA, alpha/beta subunit

    8. XM_039112435.2 → XP_038968363.1  TFIIA-alpha and beta-like factor isoform X4

      Conserved Domains (1) summary
      pfam03153
      Location:59 → 204
      TFIIA; Transcription factor IIA, alpha/beta subunit

    RNA

    1. XR_005505531.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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