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    Triobp TRIO and F-actin binding protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362956, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Triobpprovided by RGD
    Official Full Name
    TRIO and F-actin binding proteinprovided by RGD
    Primary source
    RGD:1308485
    See related
    EnsemblRapid:ENSRNOG00000059015 AllianceGenome:RGD:1308485
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable actin filament binding activity and ubiquitin protein ligase binding activity. Predicted to act upstream of or within auditory receptor cell stereocilium organization; positive regulation of substrate adhesion-dependent cell spreading; and sensory perception of sound. Predicted to be located in actin cytoskeleton and stereocilium base. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 28. Orthologous to human TRIOBP (TRIO and F-actin binding protein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 65.2), Lung (RPKM 49.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Triobp in Genome Data Viewer
    Location:
    7q34
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (112386371..112452130)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (110505916..110569301)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (120173892..120237145)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene galectin 1 Neighboring gene nucleolar protein 12 Neighboring gene H1.0 linker histone Neighboring gene glycine C-acetyltransferase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Tara, a novel F-actin binding protein, associates with the Trio guanine nucleotide exchange factor and regulates actin cytoskeletal organization. Seipel K, et al. J Cell Sci, 2001 Jan. PMID 11148140
    2. The E3 ubiquitin ligase HECTD3 regulates ubiquitination and degradation of Tara. Yu J, et al. Biochem Biophys Res Commun, 2008 Mar 21. PMID 18194665
    3. Localization and functional consequences of a direct interaction between TRIOBP-1 and hERG proteins in the heart. Jones DK, et al. J Cell Sci, 2018 Mar 22. PMID 29507111, Free PMC Article
    4. Actin-bundling protein TRIOBP forms resilient rootlets of hair cell stereocilia essential for hearing. Kitajiri S, et al. Cell, 2010 May 28. PMID 20510926, Free PMC Article
    5. Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation. Kuo JC, et al. Nat Cell Biol, 2011 Apr. PMID 21423176, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables actin filament binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within auditory receptor cell stereocilium organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of substrate adhesion-dependent cell spreading IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of substrate adhesion-dependent cell spreading ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within sensory perception of sound ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in stereocilium base ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    TRIO and F-actin-binding protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001395663.1 → NP_001382592.1  TRIO and F-actin-binding protein isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      A0A8I6AHC8, B5DFF5
      Related
      ENSRNOP00000092060.1, ENSRNOT00000112806.2
      Conserved Domains (2) summary
      cd13275
      Location:56 → 157
      PH_M-RIP; Myosin phosphatase-RhoA Interacting Protein Pleckstrin homology (PH) domain
      TIGR02168
      Location:329 → 627
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    2. NM_001409036.1 → NP_001395965.1  TRIO and F-actin-binding protein isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      A0A8I6G2J5
      Related
      ENSRNOP00000078284.1, ENSRNOT00000094572.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      112386371..112452130
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039079579.2 → XP_038935507.1  TRIO and F-actin-binding protein isoform X1

      UniProtKB/TrEMBL
      A0A8I6G2J5
      Conserved Domains (5) summary
      PHA03247
      Location:629 → 1070
      PHA03247; large tegument protein UL36; Provisional
      PHA03307
      Location:24 → 342
      PHA03307; transcriptional regulator ICP4; Provisional
      COG1196
      Location:1635 → 1946
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd13275
      Location:1375 → 1476
      PH_M-RIP; Myosin phosphatase-RhoA Interacting Protein Pleckstrin homology (PH) domain
      pfam05109
      Location:241 → 763
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

    2. XM_017594983.2 → XP_017450472.1  TRIO and F-actin-binding protein isoform X1

      UniProtKB/TrEMBL
      A0A8I6G2J5
      Related
      ENSRNOP00000071930.2, ENSRNOT00000087548.3
      Conserved Domains (5) summary
      PHA03247
      Location:629 → 1070
      PHA03247; large tegument protein UL36; Provisional
      PHA03307
      Location:24 → 342
      PHA03307; transcriptional regulator ICP4; Provisional
      COG1196
      Location:1635 → 1946
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd13275
      Location:1375 → 1476
      PH_M-RIP; Myosin phosphatase-RhoA Interacting Protein Pleckstrin homology (PH) domain
      pfam05109
      Location:241 → 763
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

    3. XM_039079581.1 → XP_038935509.1  TRIO and F-actin-binding protein isoform X2

      UniProtKB/TrEMBL
      A0A8I6G2J5
      Related
      ENSRNOP00000073745.2, ENSRNOT00000086853.3
      Conserved Domains (5) summary
      PHA03247
      Location:628 → 1069
      PHA03247; large tegument protein UL36; Provisional
      PHA03307
      Location:24 → 341
      PHA03307; transcriptional regulator ICP4; Provisional
      COG1196
      Location:1634 → 1945
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd13275
      Location:1374 → 1475
      PH_M-RIP; Myosin phosphatase-RhoA Interacting Protein Pleckstrin homology (PH) domain
      pfam05109
      Location:240 → 762
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

    4. XM_039079582.2 → XP_038935510.1  TRIO and F-actin-binding protein isoform X3

      UniProtKB/TrEMBL
      A0A8I6G2J5
      Conserved Domains (3) summary
      PHA03247
      Location:533 → 903
      PHA03247; large tegument protein UL36; Provisional
      PRK08581
      Location:249 → 521
      PRK08581; amidase domain-containing protein
      cd13275
      Location:1375 → 1476
      PH_M-RIP; Myosin phosphatase-RhoA Interacting Protein Pleckstrin homology (PH) domain

    5. XM_039079583.1 → XP_038935511.1  TRIO and F-actin-binding protein isoform X4

      Conserved Domains (2) summary
      PHA03247
      Location:554 → 903
      PHA03247; large tegument protein UL36; Provisional
      PRK08581
      Location:249 → 521
      PRK08581; amidase domain-containing protein

    6. XM_063263918.1 → XP_063119988.1  TRIO and F-actin-binding protein isoform X5

    7. XM_063263919.1 → XP_063119989.1  TRIO and F-actin-binding protein isoform X6

      UniProtKB/TrEMBL
      A0A8I6AHC8, B5DFF5

    8. XM_063263920.1 → XP_063119990.1  TRIO and F-actin-binding protein isoform X7

      UniProtKB/TrEMBL
      Q5M7V4

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001013220.2: Suppressed sequence

      Description
      NM_001013220.2: This RefSeq was removed because currently there is insufficient support for the transcript.
    Nucleotide Protein Strain
    Heading Accession and Version

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