Crtam cytotoxic and regulatory T cell molecule [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Crtamprovided by RGD
Official Full Name: cytotoxic and regulatory T cell moleculeprovided by RGD
Primary source: RGD:1304602
See related: EnsemblRapid:ENSRNOG00000008153 AllianceGenome:RGD:1304602
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable identical protein binding activity and signaling receptor binding activity. Predicted to be involved in several processes, including detection of tumor cell; establishment of T cell polarity; and regulation of T cell activation. Predicted to be located in immunological synapse. Predicted to be active in plasma membrane. Orthologous to human CRTAM (cytotoxic and regulatory T cell molecule). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 48.8), Thymus (RPKM 21.0) and 2 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q22

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (50237210..50274472, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (41340117..41377381, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (45152584..45216082, complement)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables signaling receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
NOT involved_in T cell mediated cytotoxicity	ISO Inferred from Sequence Orthology more info
NOT involved_in activated T cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in cell recognition	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell recognition	ISO Inferred from Sequence Orthology more info
involved_in detection of stimulus	ISO Inferred from Sequence Orthology more info
involved_in detection of tumor cell	IBA Inferred from Biological aspect of Ancestor more info
involved_in detection of tumor cell	ISO Inferred from Sequence Orthology more info
involved_in establishment of T cell polarity	ISO Inferred from Sequence Orthology more info
involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	ISO Inferred from Sequence Orthology more info
involved_in lymphocyte migration into lymphoid organs	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of activated T cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cytokine production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of natural killer cell mediated cytotoxicity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of type II interferon production	ISO Inferred from Sequence Orthology more info
involved_in regulation of CD8-positive, alpha-beta T cell activation	ISO Inferred from Sequence Orthology more info
involved_in regulation of T cell activation	ISO Inferred from Sequence Orthology more info
involved_in regulation of T cell differentiation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in immunological synapse	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: cytotoxic and regulatory T-cell molecule

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.