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    Hspd1 heat shock protein family D (Hsp60) member 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 63868, updated on 9-Dec-2024

    Summary

    Official Symbol
    Hspd1provided by RGD
    Official Full Name
    heat shock protein family D (Hsp60) member 1provided by RGD
    Primary source
    RGD:621314
    See related
    EnsemblRapid:ENSRNOG00000014525 AllianceGenome:RGD:621314
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Hsp60; Hspd1-30p
    Summary
    Enables modification-dependent protein binding activity. Involved in several processes, including negative regulation of apoptotic process; positive regulation of cytokine production; and response to ischemia. Located in several cellular components, including mitochondrial crista; peroxisomal matrix; and zymogen granule. Used to study Alzheimer's disease and low tension glaucoma. Biomarker of several diseases, including artery disease (multiple); hydrocephalus; hyperglycemia; pulmonary fibrosis; and varicocele. Human ortholog(s) of this gene implicated in artery disease (multiple); autistic disorder; glucose intolerance; hereditary spastic paraplegia (multiple); and hypomyelinating leukodystrophy 4. Orthologous to human HSPD1 (heat shock protein family D (Hsp60) member 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 7685.9), Kidney (RPKM 1832.5) and 7 other tissues See more
    Orthologs
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    Genomic context

    See Hspd1 in Genome Data Viewer
    Location:
    9q31
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (64073610..64084332, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (56579195..56590011, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (61680529..61691202, complement)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene splicing factor 3b, subunit 1 Neighboring gene coenzyme Q10B Neighboring gene heat shock protein family E (Hsp10) member 1 Neighboring gene glycine cleavage system H protein, mitochondrial pseudogene Neighboring gene MOB family member 4, phocein Neighboring gene raftlin family member 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding  
    enables ATP-dependent protein folding chaperone  
    enables apolipoprotein A-I binding  
    enables apolipoprotein binding  
    enables cysteine-type endopeptidase activator activity  
    enables double-stranded RNA binding  
    enables enzyme binding  
    enables high-density lipoprotein particle binding  
    enables isomerase activity  
    enables lipopolysaccharide binding  
    enables modification-dependent protein binding PubMed 
    enables p53 binding  
    enables protein binding PubMed 
    enables protein-containing complex binding PubMed 
    enables protein-folding chaperone binding  
    enables protein-folding chaperone binding  
    enables ubiquitin protein ligase binding  
    Items 1 - 25 of 54
    Process Evidence Code Pubs
    involved_in 'de novo' protein folding PubMed 
    involved_in B cell activation  
    involved_in B cell proliferation  
    involved_in MyD88-dependent toll-like receptor signaling pathway  
    involved_in T cell activation  
    acts_upstream_of_or_within T cell activation  
    NOT involved_in adhesion of symbiont to host  
    involved_in apoptotic mitochondrial changes  
    involved_in apoptotic mitochondrial changes PubMed 
    involved_in cellular response to heat PubMed 
    acts_upstream_of_or_within cellular response to interleukin-7  
    involved_in isotype switching to IgG isotypes  
    involved_in mitochondrial unfolded protein response  
    involved_in negative regulation of apoptotic process PubMed 
    involved_in negative regulation of apoptotic process  
    involved_in negative regulation of apoptotic process in bone marrow cell PubMed 
    involved_in negative regulation of execution phase of apoptosis  
    involved_in negative regulation of neuron apoptotic process PubMed 
    involved_in negative regulation of reactive oxygen species biosynthetic process PubMed 
    involved_in positive regulation of T cell activation  
    involved_in positive regulation of T cell activation  
    involved_in positive regulation of T cell mediated immune response to tumor cell  
    involved_in positive regulation of execution phase of apoptosis  
    involved_in positive regulation of interferon-alpha production  
    acts_upstream_of_or_within positive regulation of interferon-alpha production  
    involved_in positive regulation of interferon-alpha production  
    involved_in positive regulation of interleukin-10 production  
    involved_in positive regulation of interleukin-12 production  
    involved_in positive regulation of interleukin-6 production  
    involved_in positive regulation of interleukin-6 production PubMed 
    involved_in positive regulation of interleukin-6 production  
    involved_in positive regulation of macrophage activation  
    involved_in positive regulation of tumor necrosis factor production PubMed 
    involved_in positive regulation of type II interferon production  
    acts_upstream_of_or_within positive regulation of type II interferon production  
    involved_in positive regulation of type II interferon production  
    involved_in protein folding  
    involved_in protein import into mitochondrial intermembrane space  
    involved_in protein refolding  
    involved_in protein stabilization  
    involved_in response to ATP PubMed 
    involved_in response to activity PubMed 
    involved_in response to cocaine PubMed 
    involved_in response to cold  
    involved_in response to estrogen PubMed 
    involved_in response to glucocorticoid PubMed 
    involved_in response to hydrogen peroxide PubMed 
    involved_in response to hypoxia PubMed 
    involved_in response to ischemia PubMed 
    involved_in response to lipopolysaccharide PubMed 
    involved_in response to organic cyclic compound PubMed 
    involved_in response to resveratrol PubMed 
    involved_in response to unfolded protein  
    involved_in response to xenobiotic stimulus PubMed 
    Items 1 - 25 of 54
    Items 1 - 20 of 32
    Component Evidence Code Pubs
    located_in Golgi cisterna PubMed 
    located_in cell surface PubMed 
    located_in cell surface  
    located_in clathrin-coated pit  
    located_in coated vesicle  
    located_in cytoplasm  
    located_in cytosol  
    located_in early endosome  
    located_in extracellular exosome  
    located_in extracellular space PubMed 
    located_in extracellular space  
    located_in intracellular membrane-bounded organelle  
    part_of lipopolysaccharide receptor complex  
    located_in membrane  
    located_in migrasome  
    located_in mitochondrial crista PubMed 
    is_active_in mitochondrial inner membrane  
    located_in mitochondrial inner membrane PubMed 
    is_active_in mitochondrial matrix  
    is_active_in mitochondrial matrix  
    located_in mitochondrial matrix  
    is_active_in mitochondrion  
    located_in mitochondrion  
    located_in peroxisomal matrix PubMed 
    located_in plasma membrane  
    part_of protein-containing complex  
    part_of protein-containing complex  
    located_in secretory granule PubMed 
    located_in secretory granule  
    located_in sperm midpiece  
    located_in sperm plasma membrane  
    located_in zymogen granule PubMed 
    Items 1 - 20 of 32

    General protein information

    Preferred Names
    60 kDa heat shock protein, mitochondrial
    Names
    60 kDa chaperonin
    CPN60
    HSP-60
    HSP-65
    chaperonin 60
    heat shock 60kD protein 1 (chaperonin)
    heat shock 60kDa protein 1
    heat shock protein 1 (chaperonin)
    heat shock protein 60 (liver)
    heat shock protein family D member 1
    mitochondrial matrix protein P1
    NP_071565.2
    XP_006244994.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022229.2NP_071565.2  60 kDa heat shock protein, mitochondrial

      See identical proteins and their annotated locations for NP_071565.2

      Status: PROVISIONAL

      Source sequence(s)
      BC086507
      UniProtKB/Swiss-Prot
      P63039
      UniProtKB/TrEMBL
      A0A482IDN3
      Related
      ENSRNOP00000063666.2, ENSRNOT00000066589.4
      Conserved Domains (1) summary
      cd03344
      Location:28548
      GroEL; GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      64073610..64084332 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006244932.4XP_006244994.1  60 kDa heat shock protein, mitochondrial isoform X1

      See identical proteins and their annotated locations for XP_006244994.1

      UniProtKB/Swiss-Prot
      P63039
      UniProtKB/TrEMBL
      A0A482IDN3
      Conserved Domains (1) summary
      cd03344
      Location:28548
      GroEL; GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found ...
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