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    Elf4 E74 like ETS transcription factor 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 302811, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Elf4provided by RGD
    Official Full Name
    E74 like ETS transcription factor 4provided by RGD
    Primary source
    RGD:1560743
    See related
    EnsemblRapid:ENSRNOG00000005352 AllianceGenome:RGD:1560743
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1560743
    Summary
    Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in several processes, including lymphocyte proliferation; negative regulation of cytokine production; and positive regulation of transcription by RNA polymerase II. Predicted to be located in PML body. Predicted to be active in nucleus. Orthologous to human ELF4 (E74 like ETS transcription factor 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 82.9), Thymus (RPKM 58.9) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Elf4 in Genome Data Viewer
    Location:
    Xq36
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (132465290..132508175, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (127587401..127639063, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (135239626..135284330, complement)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene BCL6 co-repressor-like 1 Neighboring gene NADH:ubiquinone oxidoreductase subunit B4, pseudogene 3 Neighboring gene apoptosis inducing factor, mitochondria associated 1 Neighboring gene RAB33A, member RAS oncogene family

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Stress Granule Induction after Brain Ischemia Is Independent of Eukaryotic Translation Initiation Factor (eIF) 2α Phosphorylation and Is Correlated with a Decrease in eIF4B and eIF4E Proteins. Ayuso MI, et al. J Biol Chem, 2016 Dec 30. PMID 27836976, Free PMC Article
    2. MEF, a novel transcription factor with an Elf-1 like DNA binding domain but distinct transcriptional activating properties. Miyazaki Y, et al. Oncogene, 1996 Oct 17. PMID 8895518
    3. The ETS protein MEF plays a critical role in perforin gene expression and the development of natural killer and NK-T cells. Lacorazza HD, et al. Immunity, 2002 Oct. PMID 12387738
    4. Cloning of a novel human ELF-1-related ETS transcription factor, ELFR, its characterization and chromosomal assignment relative to ELF-1. Aryee DN, et al. Gene, 1998 Mar 27. PMID 9524226
    5. Post-transcriptional effects and interactions between chronic mild stress and acute sleep deprivation: regulation of translation factor and cytoplasmic polyadenylation element-binding protein phosphorylation. Grønli J, et al. Behav Brain Res, 2012 Dec 1. PMID 22917528

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Low eIF4E and eIF4B expression is associated with Brain Ischemia.
      Title: Stress Granule Induction after Brain Ischemia Is Independent of Eukaryotic Translation Initiation Factor (eIF) 2α Phosphorylation and Is Correlated with a Decrease in eIF4B and eIF4E Proteins.
    2. The eEF2 phosphorylation was decreased in all brain regions after sleep deprivation and enhanced
      Title: Post-transcriptional effects and interactions between chronic mild stress and acute sleep deprivation: regulation of translation factor and cytoplasmic polyadenylation element-binding protein phosphorylation.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables sequence-specific double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in NK T cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in natural killer cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of inflammatory response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of interleukin-1 beta production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of interleukin-6 production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of tumor necrosis factor production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in PML body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ETS-related transcription factor Elf-4
    Names
    E74-like factor 4 (ets domain transcription factor)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191735.2 → NP_001178664.1  ETS-related transcription factor Elf-4

      See identical proteins and their annotated locations for NP_001178664.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/TrEMBL
      A6JMQ2, D3ZWM8
      Related
      ENSRNOP00000051409.4, ENSRNOT00000044487.6
      Conserved Domains (2) summary
      pfam00178
      Location:208 → 288
      Ets; Ets-domain
      pfam12310
      Location:2 → 103
      Elf-1_N; Transcription factor protein N terminal

    2. NM_001434032.1 → NP_001420961.1  ETS-related transcription factor Elf-4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000021
      UniProtKB/TrEMBL
      A6JMQ2, D3ZWM8

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      132465290..132508175 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039099675.2 → XP_038955603.1  ETS-related transcription factor Elf-4 isoform X1

      Conserved Domains (2) summary
      pfam00178
      Location:208 → 288
      Ets; Ets-domain
      pfam12310
      Location:2 → 103
      Elf-1_N; Transcription factor protein N terminal

    2. XM_039099676.2 → XP_038955604.1  ETS-related transcription factor Elf-4 isoform X1

      Conserved Domains (2) summary
      pfam00178
      Location:208 → 288
      Ets; Ets-domain
      pfam12310
      Location:2 → 103
      Elf-1_N; Transcription factor protein N terminal
    Nucleotide Protein Strain
    Heading Accession and Version

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