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    TAAR6 trace amine associated receptor 6 [ Homo sapiens (human) ]

    Gene ID: 319100, updated on 27-Dec-2024

    Summary

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    Official Symbol
    TAAR6provided by HGNC
    Official Full Name
    trace amine associated receptor 6provided by HGNC
    Primary source
    HGNC:HGNC:20978
    See related
    Ensembl:ENSG00000146383 MIM:608923; AllianceGenome:HGNC:20978
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TA4; TAR4; TAR6; TRAR4; taR-4; taR-6
    Summary
    This gene encodes a seven-transmembrane G-protein-coupled receptor that likely functions as a receptor for endogenous trace amines. Mutations in this gene may be associated with schizophrenia.[provided by RefSeq, Feb 2010]
    Orthologs
    mouse all
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    Genomic context

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    See TAAR6 in Genome Data Viewer
    Location:
    6q23.2
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (132570322..132571359)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (133765283..133766320)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (132891461..132892498)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene trace amine associated receptor 8 Neighboring gene trace amine associated receptor 7, pseudogene Neighboring gene trace amine associated receptor 5 Neighboring gene trace amine associated receptor 4, pseudogene Neighboring gene trace amine associated receptor 3, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Suggestive evidence for a schizophrenia susceptibility locus on chromosome 6q and a confirmation in an independent series of pedigrees. Cao Q, et al. Genomics, 1997 Jul 1. PMID 9226366
    2. Association between TAAR6 polymorphisms and airway responsiveness to inhaled corticosteroids in asthmatic patients. Chang HS, et al. Pharmacogenet Genomics, 2015 Jul. PMID 25919112
    3. Failure to find association between TRAR4 and schizophrenia in the Chinese Han population. Duan S, et al. J Neural Transm (Vienna), 2006 Mar. PMID 16075187
    4. TAAR6 variations possibly associated with antidepressant response and suicidal behavior. Pae CU, et al. Psychiatry Res, 2010 Nov 30. PMID 20493543
    5. The trace amine receptor 4 gene is not associated with schizophrenia in a sample linked to chromosome 6q23. Amann D, et al. Mol Psychiatry, 2006 Feb. PMID 16189505

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Public Transcriptomic Data Meta-Analysis Demonstrates TAAR6 Expression in the Mental Disorder-Related Brain Areas in Human and Mouse Brain.
      Title: Public Transcriptomic Data Meta-Analysis Demonstrates TAAR6 Expression in the Mental Disorder-Related Brain Areas in Human and Mouse Brain.
    2. Search for Structural Basis of Interactions of Biogenic Amines with Human TAAR1 and TAAR6 Receptors.
      Title: Search for Structural Basis of Interactions of Biogenic Amines with Human TAAR1 and TAAR6 Receptors.
    3. Among the 15 SNPs and seven haplotypes of TAAR6, rs7772821 (T>G) on the 3'-UTR showed the strongest correlation with inhaled corticosteroid-induced %DeltaFEV1 in asthmatics.
      Title: Association between TAAR6 polymorphisms and airway responsiveness to inhaled corticosteroids in asthmatic patients.
    4. The results of this study suggested a possible role of TAAR6 in antidepressant response and suicide behavior in patients with depressive disorder
      Title: TAAR6 variations possibly associated with antidepressant response and suicidal behavior.
    5. an epistastic effect between a set of TAAR6 and HSP-70 gene variations has a role in major mood disorders
      Title: Investigation of an epistastic effect between a set of TAAR6 and HSP-70 genes variations and major mood disorders.
    6. This study provides preliminary evidence that HSP-70 may play a role in the disrupted mechanisms that lead to BPD.
      Title: TAAR 6 and HSP-70 variations associated with bipolar disorder.
    7. Analysis of epistasis between a set of variations located in the TAAR6 and HSP-70 genes found weak associations with the risk of psychosis and response to antipsychotic treatment
      Title: Epistasis between a set of variations located in the TAAR6 and HSP-70 genes toward schizophrenia and response to antipsychotic treatment.
    8. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
      Title: TAAR6 variations possibly associated with antidepressant response and suicidal behavior.
    9. Here we demonstrate that TAAR6 is not associated with schizophrenia in the ICCSS sample.
      Title: The trace amine associated receptor (TAAR6) gene is not associated with schizophrenia in the Irish Case-Control Study of Schizophrenia (ICCSS) sample.
    10. We reported an association between TAAR6 (trace amine associated receptor 6 gene) variations and schizophrenia (SZ). We now report an association of a set of TAAR6 variations and clinical presentation and outcome in a sample of 240 SZ Korean patients.
      Title: TAAR6 variation effect on clinic presentation and outcome in a sample of schizophrenic in-patients: an open label study.
    Submit: New GeneRIF Correction See all GeneRIFs (19)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables trace-amine receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables trace-amine receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in sensory perception of smell ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    trace amine-associated receptor 6
    Names
    trace amine receptor 4
    trace amine receptor 6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_016544.1 RefSeqGene

      Range
      5001..6038
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_175067.1 → NP_778237.1  trace amine-associated receptor 6

      See identical proteins and their annotated locations for NP_778237.1

      Status: REVIEWED

      Source sequence(s)
      AY183470
      Consensus CDS
      CCDS5155.1
      UniProtKB/Swiss-Prot
      Q5VUQ4, Q96RI8
      Related
      ENSP00000275198.1, ENST00000275198.1
      Conserved Domains (2) summary
      pfam00001
      Location:49 → 311
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:43 → 271
      7tm_4; Olfactory receptor

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      132570322..132571359
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      133765283..133766320
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96RI8.1 GenPept UniProtKB/Swiss-Prot:Q96RI8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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