U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25147, updated on 9-Dec-2024

    Summary

    Symbol
    Cyp19a1provided by RGD
    Full Name
    cytochrome P450, family 19, subfamily a, polypeptide 1provided by RGD
    Primary source
    RGD:2457
    See related
    EnsemblRapid:ENSRNOG00000000196 AllianceGenome:RGD:2457
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Cyp19; Cyp19a; p450arom; Aromatase
    Summary
    Enables aromatase activity. Involved in several processes, including carboxylic acid metabolic process; gonad development; and limbic system development. Located in several cellular components, including dendritic spine; neuronal cell body; and synaptic vesicle. Used to study endometriosis and polycystic ovary syndrome. Biomarker of hypertension; hypothyroidism; placental insufficiency; polycystic ovary syndrome; and protein-energy malnutrition. Human ortholog(s) of this gene implicated in several diseases, including aromatase excess syndrome; bladder neck obstruction; esophagus adenocarcinoma; ovarian disease (multiple); and prostate disease (multiple). Orthologous to human CYP19A1 (cytochrome P450 family 19 subfamily A member 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 2.6), Uterus (RPKM 2.1) and 7 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Cyp19a1 in Genome Data Viewer
    Location:
    8q24
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (63449148..63476534, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (54552978..54580375, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (58744849..58772408, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480054 Neighboring gene uncharacterized LOC134480170 Neighboring gene uncharacterized LOC103693097 Neighboring gene uncharacterized LOC134480173 Neighboring gene uncharacterized LOC134480172

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Items 1 - 25 of 55
    Process Evidence Code Pubs
    involved_in C21-steroid hormone metabolic process PubMed 
    involved_in adrenal gland development PubMed 
    involved_in androgen catabolic process  
    involved_in androgen catabolic process  
    involved_in androgen metabolic process PubMed 
    acts_upstream_of_or_within androgen metabolic process  
    involved_in bile acid metabolic process PubMed 
    involved_in biphenyl metabolic process PubMed 
    involved_in bone development PubMed 
    involved_in calcineurin-mediated signaling PubMed 
    involved_in cellular response to fibroblast growth factor stimulus PubMed 
    involved_in cellular response to follicle-stimulating hormone stimulus PubMed 
    involved_in cellular response to glucose stimulus PubMed 
    involved_in cellular response to gonadotropin stimulus PubMed 
    involved_in cellular response to hydrostatic pressure PubMed 
    involved_in dibenzo-p-dioxin metabolic process PubMed 
    involved_in estrogen biosynthetic process PubMed 
    involved_in female genitalia development  
    acts_upstream_of_or_within female genitalia development  
    involved_in female gonad development  
    involved_in female gonad development  
    acts_upstream_of_or_within female gonad development  
    involved_in granulocyte differentiation PubMed 
    involved_in hippocampus development PubMed 
    involved_in hypothalamus development PubMed 
    involved_in luteinization PubMed 
    involved_in male gonad development PubMed 
    involved_in mammary gland development  
    acts_upstream_of_or_within mammary gland development  
    involved_in melatonin metabolic process PubMed 
    involved_in negative regulation of bone resorption PubMed 
    involved_in negative regulation of chronic inflammatory response  
    acts_upstream_of_or_within negative regulation of chronic inflammatory response  
    involved_in negative regulation of macrophage chemotaxis  
    acts_upstream_of_or_within negative regulation of macrophage chemotaxis  
    involved_in phthalate metabolic process PubMed 
    involved_in positive regulation of estradiol secretion  
    involved_in positive regulation of estradiol secretion  
    involved_in prostate gland growth  
    acts_upstream_of_or_within prostate gland growth  
    involved_in regulation of synapse structure or activity PubMed 
    involved_in response to cesium ion PubMed 
    involved_in response to estradiol  
    involved_in response to estradiol PubMed 
    involved_in response to estrogen PubMed 
    involved_in response to herbicide PubMed 
    involved_in response to ionizing radiation PubMed 
    involved_in response to metal ion PubMed 
    involved_in response to organic cyclic compound PubMed 
    involved_in response to testosterone PubMed 
    involved_in response to xenobiotic stimulus PubMed 
    involved_in testosterone biosynthetic process  
    acts_upstream_of_or_within testosterone biosynthetic process  
    involved_in uterus development  
    acts_upstream_of_or_within uterus development  
    Items 1 - 25 of 55
    Component Evidence Code Pubs
    located_in axon terminus PubMed 
    located_in dendritic spine PubMed 
    is_active_in endoplasmic reticulum  
    located_in endoplasmic reticulum  
    located_in endoplasmic reticulum  
    located_in membrane  
    located_in neuronal cell body PubMed 
    located_in synaptic vesicle PubMed 
    located_in terminal bouton PubMed 

    General protein information

    Preferred Names
    aromatase
    Names
    CYPXIX
    Cytochrome P450, 19, aromatase
    P-450AROM
    cytochrome P-450AROM
    cytochrome P450 19A1
    cytochrome P450 19A1-like
    cytochrome P450 family 19 subfamily a
    cytochrome P450, subfamily 19
    estrogen synthase
    estrogen synthetase
    NP_058781.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_017085.3NP_058781.2  aromatase

      See identical proteins and their annotated locations for NP_058781.2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A0A8I5ZQN3, A6J4K5, F1LPY2
      Related
      ENSRNOP00000000212.7, ENSRNOT00000000212.9
      Conserved Domains (1) summary
      cd20616
      Location:72485
      CYP19A1; cytochrome P450 family 19, subfamily A, polypeptide 1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      63449148..63476534 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    External link. Please review our privacy policy.