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    Tgfbr1 transforming growth factor, beta receptor 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29591, updated on 9-Dec-2024

    Summary

    Symbol
    Tgfbr1provided by RGD
    Full Name
    transforming growth factor, beta receptor 1provided by RGD
    Primary source
    RGD:3852
    See related
    EnsemblRapid:ENSRNOG00000007036 AllianceGenome:RGD:3852
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Alk5; Skr4; Tgfr-1; tbetaR-I
    Summary
    Enables several functions, including ATP binding activity; transforming growth factor beta binding activity; and transforming growth factor beta receptor activity, type I. Involved in several processes, including regulation of miRNA transcription; response to prostaglandin E; and transforming growth factor beta receptor signaling pathway. Located in apical plasma membrane; basolateral plasma membrane; and caveola. Part of protein-containing complex. Used to study leiomyoma; osteochondrodysplasia; and pulmonary hypertension. Biomarker of kidney disease and myocardial infarction. Human ortholog(s) of this gene implicated in Loeys-Dietz syndrome 1; Lynch syndrome; carcinoma (multiple); colorectal cancer; and urinary bladder cancer. Orthologous to human TGFBR1 (transforming growth factor beta receptor 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 195.8), Thymus (RPKM 187.5) and 9 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Tgfbr1 in Genome Data Viewer
    Location:
    5q22
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (66449348..66506371)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (61653773..61710777)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (63056071..63119635)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102551073 Neighboring gene collagen type XV alpha 1 chain Neighboring gene uncharacterized LOC120102870 Neighboring gene uncharacterized LOC120102871 Neighboring gene ALG2, alpha-1,3/1,6-mannosyltransferase

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • MGC93659

    Gene Ontology Provided by RGD

    Items 1 - 25 of 38
    Function Evidence Code Pubs
    enables ATP binding  
    enables ATP binding PubMed 
    enables ATP binding  
    enables BMP receptor activity  
    enables I-SMAD binding  
    enables I-SMAD binding  
    enables SMAD binding  
    enables SMAD binding  
    enables activin binding  
    enables activin receptor activity, type I  
    enables activin receptor activity, type II  
    contributes_to growth factor binding  
    enables metal ion binding  
    enables protein kinase activity  
    enables protein serine/threonine kinase activity PubMed 
    enables protein serine/threonine kinase activity  
    enables protein-containing complex binding PubMed 
    enables protein-containing complex binding PubMed 
    enables signaling receptor binding  
    enables transforming growth factor beta binding PubMed 
    enables transforming growth factor beta binding  
    contributes_to transforming growth factor beta binding  
    enables transforming growth factor beta binding  
    contributes_to transforming growth factor beta receptor activity  
    enables transforming growth factor beta receptor activity  
    enables transforming growth factor beta receptor activity, type I  
    enables transforming growth factor beta receptor activity, type I  
    enables transforming growth factor beta receptor activity, type I PubMed 
    enables transforming growth factor beta receptor activity, type I  
    enables transforming growth factor beta receptor activity, type I  
    enables transforming growth factor beta receptor activity, type II  
    enables transforming growth factor beta receptor activity, type III  
    enables transmembrane receptor protein serine/threonine kinase activity  
    enables type II transforming growth factor beta receptor binding  
    enables type II transforming growth factor beta receptor binding  
    enables ubiquitin protein ligase binding  
    enables ubiquitin protein ligase binding PubMed 
    enables ubiquitin protein ligase binding  
    Items 1 - 25 of 38
    Items 1 - 25 of 149
    Process Evidence Code Pubs
    involved_in BMP signaling pathway  
    involved_in activin receptor signaling pathway  
    involved_in activin receptor signaling pathway  
    acts_upstream_of_or_within angiogenesis  
    involved_in angiogenesis involved in coronary vascular morphogenesis  
    involved_in angiogenesis involved in coronary vascular morphogenesis  
    involved_in animal organ regeneration PubMed 
    involved_in anterior/posterior pattern specification  
    acts_upstream_of_or_within anterior/posterior pattern specification  
    involved_in apoptotic process  
    acts_upstream_of apoptotic process  
    acts_upstream_of_or_within artery morphogenesis  
    involved_in blastocyst development  
    acts_upstream_of_or_within blastocyst development  
    involved_in cardiac epithelial to mesenchymal transition  
    involved_in cell motility  
    involved_in cellular response to growth factor stimulus  
    involved_in cellular response to transforming growth factor beta stimulus  
    involved_in collagen fibril organization  
    acts_upstream_of_or_within collagen fibril organization  
    involved_in coronary artery morphogenesis  
    involved_in coronary artery morphogenesis  
    involved_in digestive tract development PubMed 
    involved_in embryo implantation PubMed 
    involved_in embryonic cranial skeleton morphogenesis  
    acts_upstream_of_or_within embryonic cranial skeleton morphogenesis  
    involved_in endothelial cell activation  
    involved_in endothelial cell migration  
    acts_upstream_of_or_within endothelial cell migration  
    involved_in endothelial cell proliferation  
    acts_upstream_of endothelial cell proliferation  
    involved_in epicardium morphogenesis  
    involved_in epicardium morphogenesis  
    involved_in epithelial to mesenchymal transition  
    involved_in epithelial to mesenchymal transition  
    involved_in filopodium assembly  
    acts_upstream_of filopodium assembly  
    involved_in germ cell migration  
    acts_upstream_of_or_within germ cell migration  
    involved_in heart development  
    acts_upstream_of_or_within heart development  
    involved_in heart development  
    acts_upstream_of_or_within in utero embryonic development  
    involved_in intracellular signal transduction  
    involved_in kidney development  
    acts_upstream_of_or_within kidney development  
    involved_in lens development in camera-type eye  
    acts_upstream_of_or_within lens development in camera-type eye  
    involved_in lung development PubMed 
    involved_in male gonad development  
    acts_upstream_of_or_within male gonad development  
    involved_in mesenchymal cell differentiation  
    involved_in myofibroblast differentiation  
    involved_in myofibroblast differentiation  
    acts_upstream_of_or_within negative regulation of apoptotic process  
    involved_in negative regulation of cell migration  
    acts_upstream_of negative regulation of cell migration  
    involved_in negative regulation of chondrocyte differentiation  
    involved_in negative regulation of chondrocyte differentiation  
    involved_in negative regulation of endothelial cell differentiation PubMed 
    involved_in negative regulation of endothelial cell proliferation  
    acts_upstream_of_or_within negative regulation of endothelial cell proliferation  
    involved_in negative regulation of extrinsic apoptotic signaling pathway  
    involved_in negative regulation of extrinsic apoptotic signaling pathway  
    involved_in negative regulation of miRNA transcription PubMed 
    involved_in nervous system development  
    involved_in neuron fate commitment  
    acts_upstream_of_or_within neuron fate commitment  
    involved_in parathyroid gland development  
    acts_upstream_of_or_within parathyroid gland development  
    involved_in peptidyl-serine phosphorylation  
    involved_in pharyngeal system development  
    acts_upstream_of_or_within pharyngeal system development  
    involved_in positive regulation of DNA-templated transcription  
    involved_in positive regulation of DNA-templated transcription  
    involved_in positive regulation of DNA-templated transcription  
    involved_in positive regulation of SMAD protein signal transduction  
    involved_in positive regulation of SMAD protein signal transduction  
    involved_in positive regulation of apoptotic process  
    involved_in positive regulation of apoptotic signaling pathway  
    involved_in positive regulation of apoptotic signaling pathway  
    involved_in positive regulation of cell growth  
    involved_in positive regulation of cell growth  
    involved_in positive regulation of cell migration  
    involved_in positive regulation of cell migration  
    involved_in positive regulation of cell population proliferation  
    involved_in positive regulation of endothelial cell proliferation  
    involved_in positive regulation of epithelial to mesenchymal transition  
    involved_in positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation  
    involved_in positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation  
    involved_in positive regulation of extracellular matrix assembly  
    acts_upstream_of positive regulation of extracellular matrix assembly  
    involved_in positive regulation of filopodium assembly  
    acts_upstream_of_or_within positive regulation of filopodium assembly  
    involved_in positive regulation of gene expression  
    involved_in positive regulation of gene expression  
    involved_in positive regulation of gene expression  
    involved_in positive regulation of mesenchymal stem cell proliferation  
    involved_in positive regulation of mesenchymal stem cell proliferation  
    involved_in positive regulation of miRNA transcription PubMed 
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  
    involved_in positive regulation of stress fiber assembly  
    involved_in positive regulation of stress fiber assembly  
    involved_in positive regulation of tight junction disassembly  
    involved_in positive regulation of tight junction disassembly  
    involved_in positive regulation of vasculature development  
    involved_in positive regulation of vasculature development  
    involved_in post-embryonic development  
    acts_upstream_of_or_within post-embryonic development  
    NOT involved_in proepicardium development  
    involved_in protein autophosphorylation PubMed 
    involved_in protein phosphorylation PubMed 
    involved_in regulation of DNA-templated transcription  
    involved_in regulation of cardiac muscle cell proliferation  
    involved_in regulation of cardiac muscle cell proliferation  
    involved_in regulation of epithelial to mesenchymal transition  
    acts_upstream_of_or_within regulation of gene expression  
    involved_in regulation of gene expression  
    involved_in regulation of protein ubiquitination  
    involved_in regulation of protein ubiquitination  
    involved_in response to cholesterol  
    involved_in response to cholesterol  
    involved_in response to electrical stimulus PubMed 
    involved_in response to estrogen PubMed 
    involved_in response to hypoxia PubMed 
    involved_in response to organic cyclic compound PubMed 
    involved_in response to prostaglandin E PubMed 
    involved_in response to toxic substance PubMed 
    involved_in roof of mouth development  
    acts_upstream_of_or_within roof of mouth development  
    involved_in signal transduction  
    acts_upstream_of_or_within skeletal system development  
    acts_upstream_of_or_within skeletal system morphogenesis  
    involved_in thymus development  
    acts_upstream_of_or_within thymus development  
    involved_in transforming growth factor beta receptor signaling pathway  
    involved_in transforming growth factor beta receptor signaling pathway  
    involved_in transforming growth factor beta receptor signaling pathway PubMed 
    acts_upstream_of_or_within transforming growth factor beta receptor signaling pathway  
    involved_in transforming growth factor beta receptor signaling pathway  
    involved_in transforming growth factor beta receptor signaling pathway  
    involved_in vascular endothelial cell proliferation  
    involved_in ventricular compact myocardium morphogenesis  
    involved_in ventricular compact myocardium morphogenesis  
    involved_in ventricular septum morphogenesis  
    involved_in ventricular septum morphogenesis  
    involved_in ventricular trabecula myocardium morphogenesis  
    involved_in ventricular trabecula myocardium morphogenesis  
    Items 1 - 25 of 149
    Items 1 - 20 of 24
    Component Evidence Code Pubs
    part_of activin receptor complex  
    located_in apical plasma membrane PubMed 
    located_in basolateral plasma membrane PubMed 
    located_in bicellular tight junction  
    located_in bicellular tight junction  
    located_in caveola PubMed 
    located_in cell surface  
    located_in cell surface  
    located_in cell surface  
    located_in endosome  
    located_in endosome  
    located_in endosome  
    located_in membrane raft PubMed 
    located_in membrane raft  
    located_in membrane raft  
    located_in nucleus  
    located_in nucleus  
    located_in nucleus  
    is_active_in plasma membrane  
    located_in plasma membrane  
    part_of protein-containing complex PubMed 
    part_of receptor complex  
    part_of transforming growth factor beta ligand-receptor complex  
    part_of transforming growth factor beta ligand-receptor complex  
    Items 1 - 20 of 24

    General protein information

    Preferred Names
    TGF-beta receptor type-1
    Names
    TGF-beta receptor type I
    TGF-beta receptor type-1-like
    TGF-beta type I receptor
    activin receptor-like kinase 5
    serine/threonine-protein kinase receptor R4
    transforming growth factor, beta receptor I
    transforming growth factor-beta receptor type I
    NP_036907.2
    XP_006238092.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001429656.1NP_001416585.1  TGF-beta receptor type-1 isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/Swiss-Prot
      P80204
      UniProtKB/TrEMBL
      A0A0H2UHE8
    2. NM_012775.3NP_036907.2  TGF-beta receptor type-1 isoform 2 precursor

      See identical proteins and their annotated locations for NP_036907.2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      A0A0H2UHE8, Q5M9H3
      Related
      ENSRNOP00000112028.1, ENSRNOT00000147514.1
      Conserved Domains (4) summary
      cd14143
      Location:203490
      STKc_TGFbR1_ACVR1b_ACVR1c; Catalytic domain of the Serine/Threonine Kinases, Transforming Growth Factor beta Type I Receptor and Activin Type IB/IC Receptors
      pfam01064
      Location:30108
      Activin_recp; Activin types I and II receptor domain
      pfam07714
      Location:199486
      Pkinase_Tyr; Protein tyrosine kinase
      pfam08515
      Location:170197
      TGF_beta_GS; Transforming growth factor beta type I GS-motif

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      66449348..66506371
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006238030.5XP_006238092.2  TGF-beta receptor type-1 isoform X1

      Related
      ENSRNOP00000009452.5, ENSRNOT00000009452.8
      Conserved Domains (4) summary
      cd14143
      Location:207494
      STKc_TGFbR1_ACVR1b_ACVR1c; Catalytic domain of the Serine/Threonine Kinases, Transforming Growth Factor beta Type I Receptor and Activin Type IB/IC Receptors
      pfam01064
      Location:30108
      Activin_recp; Activin types I and II receptor domain
      pfam07714
      Location:203490
      Pkinase_Tyr; Protein tyrosine kinase
      pfam08515
      Location:174201
      TGF_beta_GS; Transforming growth factor beta type I GS-motif
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