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    Il2 interleukin 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 116562, updated on 9-Dec-2024

    Summary

    Official Symbol
    Il2provided by RGD
    Official Full Name
    interleukin 2provided by RGD
    Primary source
    RGD:620047
    See related
    EnsemblRapid:ENSRNOG00000017348 AllianceGenome:RGD:620047
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables carbohydrate binding activity; glycosphingolipid binding activity; and signaling receptor binding activity. Involved in several processes, including positive regulation of T cell activation; positive regulation of dendritic spine development; and regulation of protein phosphorylation. Located in extracellular space. Used to study cystitis. Biomarker of allergic rhinitis; brain infarction; colorectal carcinoma; and tongue squamous cell carcinoma. Human ortholog(s) of this gene implicated in several diseases, including Takayasu's arteritis; auditory system disease (multiple); autoimmune disease (multiple); carcinoma (multiple); and neurodegenerative disease (multiple). Orthologous to human IL2 (interleukin 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 9.7), Thymus (RPKM 1.9) and 1 other tissue See more
    Orthologs
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    Genomic context

    See Il2 in Genome Data Viewer
    Location:
    2q25
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (121932968..121937672, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (120004862..120009566, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (123847150..123851854, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein L7, pseudogene 22 Neighboring gene bridge-like lipid transfer protein family member 1 Neighboring gene THUMP domain containing 1, pseudogene 1 Neighboring gene adenosine deaminase domain containing 1 Neighboring gene interleukin 21 Neighboring gene centrin 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables carbohydrate binding PubMed 
    enables cytokine activity PubMed 
    enables cytokine activity  
    enables glycosphingolipid binding PubMed 
    enables growth factor activity  
    enables interleukin-2 receptor binding PubMed 
    enables interleukin-2 receptor binding  
    enables kappa-type opioid receptor binding PubMed 
    Items 1 - 25 of 39
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway PubMed 
    acts_upstream_of T cell proliferation  
    acts_upstream_of activated T cell proliferation  
    involved_in adaptive immune response  
    involved_in cell surface receptor signaling pathway via STAT  
    acts_upstream_of_or_within extrinsic apoptotic signaling pathway in absence of ligand  
    acts_upstream_of_or_within gene expression  
    involved_in interleukin-2-mediated signaling pathway  
    involved_in leukocyte activation involved in immune response  
    acts_upstream_of lymphocyte proliferation  
    acts_upstream_of_or_within negative regulation of B cell apoptotic process  
    involved_in negative regulation of T-helper 17 cell differentiation  
    acts_upstream_of_or_within negative regulation of inflammatory response  
    acts_upstream_of_or_within negative regulation of lymphocyte proliferation  
    involved_in negative regulation of protein phosphorylation PubMed 
    involved_in phospholipase C-activating G protein-coupled receptor signaling pathway PubMed 
    acts_upstream_of_or_within positive regulation of B cell proliferation  
    involved_in positive regulation of T cell differentiation PubMed 
    involved_in positive regulation of T cell proliferation PubMed 
    acts_upstream_of_or_within positive regulation of T cell proliferation  
    acts_upstream_of_or_within positive regulation of activated T cell proliferation  
    involved_in positive regulation of cytosolic calcium ion concentration PubMed 
    involved_in positive regulation of dendritic spine development PubMed 
    acts_upstream_of positive regulation of immunoglobulin production  
    acts_upstream_of_or_within positive regulation of immunoglobulin production  
    involved_in positive regulation of interleukin-17 production  
    acts_upstream_of_or_within positive regulation of isotype switching to IgG isotypes  
    acts_upstream_of positive regulation of plasma cell differentiation  
    involved_in positive regulation of protein phosphorylation PubMed 
    involved_in positive regulation of regulatory T cell differentiation PubMed 
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II  
    acts_upstream_of_or_within positive regulation of type II interferon production  
    acts_upstream_of_or_within positive regulation of tyrosine phosphorylation of STAT protein  
    acts_upstream_of_or_within regulation of CD4-positive, alpha-beta T cell proliferation  
    acts_upstream_of_or_within regulation of T cell homeostatic proliferation  
    involved_in response to ethanol PubMed 
    involved_in response to tacrolimus PubMed 
    acts_upstream_of transcription by RNA polymerase II  
    acts_upstream_of tyrosine phosphorylation of STAT protein  
    Items 1 - 25 of 39
    Component Evidence Code Pubs
    located_in extracellular space PubMed 
    is_active_in extracellular space  
    located_in extracellular space  

    General protein information

    Preferred Names
    interleukin-2
    Names
    IL-2
    T-cell growth factor
    TCGF

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053836.1NP_446288.1  interleukin-2 precursor

      See identical proteins and their annotated locations for NP_446288.1

      Status: PROVISIONAL

      Source sequence(s)
      M22899
      UniProtKB/Swiss-Prot
      P17108
      UniProtKB/TrEMBL
      A6IHZ7
      Related
      ENSRNOP00000023327.1, ENSRNOT00000023327.4
      Conserved Domains (1) summary
      pfam00715
      Location:8151
      IL2; Interleukin 2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      121932968..121937672 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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