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    Pam peptidylglycine alpha-amidating monooxygenase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25508, updated on 4-Jan-2025

    Summary

    Symbol
    Pamprovided by RGD
    Full Name
    peptidylglycine alpha-amidating monooxygenaseprovided by RGD
    Primary source
    RGD:3252
    See related
    EnsemblRapid:ENSRNOG00000033280 AllianceGenome:RGD:3252
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    PHM
    Summary
    Enables several functions, including metal ion binding activity; peptidylamidoglycolate lyase activity; and peptidylglycine monooxygenase activity. Involved in several processes, including fatty acid primary amide biosynthetic process; lactation; and peptide amidation. Located in several cellular components, including perikaryon; perinuclear region of cytoplasm; and trans-Golgi network. Biomarker of hypothyroidism. Orthologous to human PAM (peptidylglycine alpha-amidating monooxygenase). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Heart (RPKM 2320.3), Lung (RPKM 427.0) and 5 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Pam in Genome Data Viewer
    Location:
    9q36
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (105445812..105719287)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (97998581..98271966)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (111028543..111177588)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene solute carrier organic anion transporter family, member 6d1 Neighboring gene tumor protein, translationally-controlled 1 pseudogene 6 Neighboring gene potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2-like Neighboring gene diphosphoinositol pentakisphosphate kinase 2 Neighboring gene gypsy retrotransposon integrase 1 Neighboring gene transfer RNA proline (anticodon AGG) 31

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables L-ascorbic acid binding  
    enables calcium ion binding PubMed 
    enables chromatin binding  
    enables copper ion binding PubMed 
    enables copper ion binding  
    enables identical protein binding PubMed 
    enables lyase activity  
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen  
    enables peptidylamidoglycolate lyase activity PubMed 
    enables peptidylamidoglycolate lyase activity  
    enables peptidylamidoglycolate lyase activity  
    enables peptidylglycine monooxygenase activity  
    enables peptidylglycine monooxygenase activity PubMed 
    enables peptidylglycine monooxygenase activity  
    enables peptidylglycine monooxygenase activity  
    enables protein binding PubMed 
    enables protein kinase binding PubMed 
    enables zinc ion binding PubMed 
    enables zinc ion binding  
    enables zinc ion binding  
    Process Evidence Code Pubs
    involved_in fatty acid primary amide biosynthetic process PubMed 
    involved_in heart development PubMed 
    involved_in lactation PubMed 
    involved_in limb development PubMed 
    involved_in long-chain fatty acid metabolic process PubMed 
    involved_in maternal process involved in female pregnancy PubMed 
    acts_upstream_of_or_within mitotic chromosome condensation  
    involved_in ovulation cycle process PubMed 
    involved_in peptide amidation PubMed 
    involved_in peptide amidation  
    involved_in peptide amidation  
    involved_in peptide metabolic process PubMed 
    involved_in peptide metabolic process  
    involved_in regulation of actin cytoskeleton organization PubMed 
    involved_in regulation of transcription by RNA polymerase II PubMed 
    involved_in response to copper ion PubMed 
    involved_in response to estradiol PubMed 
    involved_in response to glucocorticoid PubMed 
    involved_in response to hypoxia PubMed 
    involved_in response to pH PubMed 
    involved_in response to xenobiotic stimulus PubMed 
    involved_in response to zinc ion  
    involved_in response to zinc ion  
    involved_in toxin metabolic process PubMed 
    Component Evidence Code Pubs
    located_in cell surface PubMed 
    located_in chromatin  
    located_in condensed chromosome  
    is_active_in extracellular region  
    located_in extracellular space PubMed 
    located_in neuronal cell body PubMed 
    located_in perikaryon PubMed 
    located_in perinuclear region of cytoplasm PubMed 
    located_in secretory granule PubMed 
    located_in trans-Golgi network PubMed 
    located_in transport vesicle membrane  

    General protein information

    Preferred Names
    peptidylglycine alpha-amidating monooxygenase
    Names
    basic salivary proline-rich protein 4-like
    peptidyl-glycine alpha-amidating monooxygenase
    NP_037132.2
    XP_006245656.1
    XP_006245659.1
    XP_008765582.1
    XP_017451775.1
    XP_017451776.1
    XP_038938966.1
    XP_038938967.1
    XP_038938968.1
    XP_038938969.1
    XP_038938970.1
    XP_038938971.1
    XP_038938972.1
    XP_038938973.1
    XP_038938974.1
    XP_038938975.1
    XP_038938976.1
    XP_038938977.1
    XP_063122753.1
    XP_063122754.1
    XP_063122755.1
    XP_063122756.1
    XP_063122757.1
    XP_063122758.1
    XP_063122759.1
    XP_063122760.1
    XP_063122761.1
    XP_063122762.1
    XP_063122763.1
    XP_063122764.1
    XP_063122765.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013000.3NP_037132.2  peptidylglycine alpha-amidating monooxygenase precursor

      See identical proteins and their annotated locations for NP_037132.2

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/Swiss-Prot
      P14925, P70710, Q64616, Q64668
      UniProtKB/TrEMBL
      A0A8L2QMN5, A6JR60
      Conserved Domains (3) summary
      cd14958
      Location:503810
      NHL_PAL_like; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5)
      pfam01082
      Location:64173
      Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
      pfam03712
      Location:201347
      Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      105445812..105719287
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039083040.2XP_038938968.1  peptidylglycine alpha-amidating monooxygenase isoform X2

      UniProtKB/Swiss-Prot
      P14925, P70710, Q64616, Q64668
      UniProtKB/TrEMBL
      A0A8L2QMN5, A6JR60
      Related
      ENSRNOP00000046774.7, ENSRNOT00000043451.8
      Conserved Domains (3) summary
      cd14958
      Location:503810
      NHL_PAL_like; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5)
      pfam01082
      Location:64173
      Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
      pfam03712
      Location:201347
      Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain
    2. XM_063266691.1XP_063122761.1  peptidylglycine alpha-amidating monooxygenase isoform X13

      UniProtKB/TrEMBL
      A0A8I5ZMR1, A6JR72
    3. XM_039083046.2XP_038938974.1  peptidylglycine alpha-amidating monooxygenase isoform X12

      UniProtKB/TrEMBL
      A0A8I5ZMR1
      Conserved Domains (3) summary
      cd14958
      Location:398705
      NHL_PAL_like; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5)
      pfam01082
      Location:64173
      Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
      pfam03712
      Location:201347
      Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain
    4. XM_039083038.2XP_038938966.1  peptidylglycine alpha-amidating monooxygenase isoform X1

      UniProtKB/TrEMBL
      A0A8L2QMN5
      Conserved Domains (3) summary
      cd14958
      Location:503810
      NHL_PAL_like; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5)
      pfam01082
      Location:64173
      Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
      pfam03712
      Location:201347
      Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain
    5. XM_063266686.1XP_063122756.1  peptidylglycine alpha-amidating monooxygenase isoform X2

      UniProtKB/Swiss-Prot
      P14925, P70710, Q64616, Q64668
      UniProtKB/TrEMBL
      A0A8L2QMN5, A6JR60
    6. XM_063266687.1XP_063122757.1  peptidylglycine alpha-amidating monooxygenase isoform X9

      UniProtKB/TrEMBL
      A0A8I5ZMR1
    7. XM_063266690.1XP_063122760.1  peptidylglycine alpha-amidating monooxygenase isoform X11

      UniProtKB/TrEMBL
      A0A8I5ZMR1
    8. XM_063266694.1XP_063122764.1  peptidylglycine alpha-amidating monooxygenase isoform X15

      UniProtKB/TrEMBL
      A0A8I5ZMR1
    9. XM_063266695.1XP_063122765.1  peptidylglycine alpha-amidating monooxygenase isoform X16

      UniProtKB/TrEMBL
      A0A8I5ZMR1
    10. XM_063266688.1XP_063122758.1  peptidylglycine alpha-amidating monooxygenase isoform X10

      UniProtKB/TrEMBL
      A0A8I5ZMR1, A6JR70
    11. XM_039083044.2XP_038938972.1  peptidylglycine alpha-amidating monooxygenase isoform X10

      UniProtKB/TrEMBL
      A0A8I5ZMR1, A6JR70
      Related
      ENSRNOP00000079092.3, ENSRNOT00000102263.3
      Conserved Domains (3) summary
      cd14958
      Location:398705
      NHL_PAL_like; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5)
      pfam01082
      Location:64173
      Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
      pfam03712
      Location:201347
      Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain
    12. XM_039083049.2XP_038938977.1  peptidylglycine alpha-amidating monooxygenase isoform X16

      UniProtKB/TrEMBL
      A0A8I5ZMR1
      Conserved Domains (3) summary
      cd14958
      Location:398705
      NHL_PAL_like; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5)
      pfam01082
      Location:64173
      Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
      pfam03712
      Location:201347
      Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain
    13. XM_063266693.1XP_063122763.1  peptidylglycine alpha-amidating monooxygenase isoform X14

      UniProtKB/TrEMBL
      A0A8I5ZMR1
    14. XM_039083047.2XP_038938975.1  peptidylglycine alpha-amidating monooxygenase isoform X13

      UniProtKB/TrEMBL
      A0A8I5ZMR1, A6JR72
      Conserved Domains (3) summary
      cd14958
      Location:398705
      NHL_PAL_like; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5)
      pfam01082
      Location:64173
      Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
      pfam03712
      Location:201347
      Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain
    15. XM_017596286.3XP_017451775.1  peptidylglycine alpha-amidating monooxygenase isoform X1

      UniProtKB/TrEMBL
      A0A8L2QMN5
      Conserved Domains (3) summary
      cd14958
      Location:503810
      NHL_PAL_like; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5)
      pfam01082
      Location:64173
      Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
      pfam03712
      Location:201347
      Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain
    16. XM_039083041.2XP_038938969.1  peptidylglycine alpha-amidating monooxygenase isoform X5

      UniProtKB/TrEMBL
      A0A8L2QMN5, A6JR64
      Related
      ENSRNOP00000098552.2, ENSRNOT00000120994.2
      Conserved Domains (3) summary
      cd14958
      Location:503810
      NHL_PAL_like; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5)
      pfam01082
      Location:64173
      Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
      pfam03712
      Location:201347
      Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain
    17. XM_017596287.3XP_017451776.1  peptidylglycine alpha-amidating monooxygenase isoform X3

      UniProtKB/TrEMBL
      A0A8L2QMN5
    18. XM_006245594.5XP_006245656.1  peptidylglycine alpha-amidating monooxygenase isoform X4

      UniProtKB/TrEMBL
      A0A8L2QMN5
      Conserved Domains (3) summary
      cd14958
      Location:503810
      NHL_PAL_like; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5)
      pfam01082
      Location:64173
      Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
      pfam03712
      Location:201347
      Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain
    19. XM_008767360.4XP_008765582.1  peptidylglycine alpha-amidating monooxygenase isoform X6

      UniProtKB/TrEMBL
      A0A8L2QMN5
      Conserved Domains (3) summary
      cd14958
      Location:503810
      NHL_PAL_like; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5)
      pfam01082
      Location:64173
      Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
      pfam03712
      Location:201347
      Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain
    20. XM_039083042.2XP_038938970.1  peptidylglycine alpha-amidating monooxygenase isoform X7

      UniProtKB/TrEMBL
      A0A8L2QMN5, A6JR66
      Conserved Domains (3) summary
      cd14958
      Location:503810
      NHL_PAL_like; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5)
      pfam01082
      Location:64173
      Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
      pfam03712
      Location:201347
      Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain
    21. XM_006245597.5XP_006245659.1  peptidylglycine alpha-amidating monooxygenase isoform X8

      UniProtKB/TrEMBL
      A0A8L2QMN5
      Conserved Domains (3) summary
      cd14958
      Location:503810
      NHL_PAL_like; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5)
      pfam01082
      Location:64173
      Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
      pfam03712
      Location:201347
      Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain
    22. XM_039083043.2XP_038938971.1  peptidylglycine alpha-amidating monooxygenase isoform X9

      UniProtKB/TrEMBL
      A0A8I5ZMR1
      Conserved Domains (3) summary
      cd14958
      Location:398705
      NHL_PAL_like; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5)
      pfam01082
      Location:64173
      Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
      pfam03712
      Location:201347
      Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain
    23. XM_039083045.2XP_038938973.1  peptidylglycine alpha-amidating monooxygenase isoform X11

      UniProtKB/TrEMBL
      A0A8I5ZMR1
      Conserved Domains (3) summary
      cd14958
      Location:398705
      NHL_PAL_like; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5)
      pfam01082
      Location:64173
      Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
      pfam03712
      Location:201347
      Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain
    24. XM_039083048.2XP_038938976.1  peptidylglycine alpha-amidating monooxygenase isoform X15

      UniProtKB/TrEMBL
      A0A8I5ZMR1
      Conserved Domains (3) summary
      cd14958
      Location:398705
      NHL_PAL_like; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5)
      pfam01082
      Location:64173
      Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
      pfam03712
      Location:201347
      Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain
    25. XM_063266684.1XP_063122754.1  peptidylglycine alpha-amidating monooxygenase isoform X1

      UniProtKB/TrEMBL
      A0A8L2QMN5
    26. XM_063266689.1XP_063122759.1  peptidylglycine alpha-amidating monooxygenase isoform X10

      UniProtKB/TrEMBL
      A0A8I5ZMR1, A6JR70
    27. XM_063266685.1XP_063122755.1  peptidylglycine alpha-amidating monooxygenase isoform X1

      UniProtKB/TrEMBL
      A0A8L2QMN5
    28. XM_039083039.2XP_038938967.1  peptidylglycine alpha-amidating monooxygenase isoform X1

      UniProtKB/TrEMBL
      A0A8L2QMN5
      Conserved Domains (3) summary
      cd14958
      Location:503810
      NHL_PAL_like; Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5)
      pfam01082
      Location:64173
      Cu2_monooxygen; Copper type II ascorbate-dependent monooxygenase, N-terminal domain
      pfam03712
      Location:201347
      Cu2_monoox_C; Copper type II ascorbate-dependent monooxygenase, C-terminal domain
    29. XM_063266692.1XP_063122762.1  peptidylglycine alpha-amidating monooxygenase isoform X13

      UniProtKB/TrEMBL
      A0A8I5ZMR1, A6JR72
    30. XM_063266683.1XP_063122753.1  peptidylglycine alpha-amidating monooxygenase isoform X1

      UniProtKB/TrEMBL
      A0A8L2QMN5
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