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    Il1rl1 interleukin 1 receptor-like 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25556, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Il1rl1provided by RGD
    Official Full Name
    interleukin 1 receptor-like 1provided by RGD
    Primary source
    RGD:2894
    See related
    EnsemblRapid:ENSRNOG00000014835 AllianceGenome:RGD:2894
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    St2; FIT1; Fit-1
    Summary
    Predicted to enable interleukin-33 binding activity and interleukin-33 receptor activity. Involved in several processes, including cellular response to mechanical stimulus; cellular response to peptide; and negative regulation of cell population proliferation. Located in external side of plasma membrane and extracellular space. Biomarker of acute myocardial infarction and bacterial pneumonia. Human ortholog(s) of this gene implicated in asthma and coronary artery disease. Orthologous to human IL1RL1 (interleukin 1 receptor like 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 50.7), Lung (RPKM 21.2) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Il1rl1 in Genome Data Viewer
    Location:
    9q22
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (50157326..50222888)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (42661694..42727266)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (47133483..47184316)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene interleukin 1 receptor type 1 Neighboring gene interleukin 1 receptor-like 2 Neighboring gene interleukin 18 receptor 1 Neighboring gene interleukin 18 receptor accessory protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Inhibition of T1/ST2 during respiratory syncytial virus infection prevents T helper cell type 2 (Th2)- but not Th1-driven immunopathology. Walzl G, et al. J Exp Med, 2001 Apr 2. PMID 11283151, Free PMC Article
    2. Elevated soluble ST2 protein levels in sera of patients with asthma with an acute exacerbation. Oshikawa K, et al. Am J Respir Crit Care Med, 2001 Jul 15. PMID 11463601
    3. The increase in serum soluble ST2 protein upon acute exacerbation of idiopathic pulmonary fibrosis. Tajima S, et al. Chest, 2003 Oct. PMID 14555548
    4. The IL-33/ST2 Axis in Immune Responses Against Parasitic Disease: Potential Therapeutic Applications. Ryan N, et al. Front Cell Infect Microbiol, 2020. PMID 32363166, Free PMC Article
    5. Resolution of allergic inflammation and airway hyperreactivity is dependent upon disruption of the T1/ST2-IL-33 pathway. Kearley J, et al. Am J Respir Crit Care Med, 2009 May 1. PMID 19179489, Free PMC Article

    See all (74) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mechanistic role of RND3-regulated IL33/ST2 signaling on cardiomyocyte senescence.
      Title: Mechanistic role of RND3-regulated IL33/ST2 signaling on cardiomyocyte senescence.
    2. Electroacupuncture prevents the development or establishment of chronic pain via IL-33/ST2 signaling in hyperalgesic priming model rats.
      Title: Electroacupuncture prevents the development or establishment of chronic pain via IL-33/ST2 signaling in hyperalgesic priming model rats.
    3. Unveiling IL-33/ST2 Pathway Unbalance in Cardiac Remodeling Due to Obesity in Zucker Fatty Rats.
      Title: Unveiling IL-33/ST2 Pathway Unbalance in Cardiac Remodeling Due to Obesity in Zucker Fatty Rats.
    4. ST2 silencing aggravates ventricular remodeling and chronic heart failure in rats by mediating the IL-33/ST2 axis.
      Title: ST2 silencing aggravates ventricular remodeling and chronic heart failure in rats by mediating the IL-33/ST2 axis.
    5. MicroRNA-547-5p-mediated interleukin-33/suppressor of tumorigenicity 2 signaling underlies the genesis and maintenance of neuropathic pain and is targeted by the therapy with bone marrow stromal cells.
      Title: MicroRNA-547-5p-mediated interleukin-33/suppressor of tumorigenicity 2 signaling underlies the genesis and maintenance of neuropathic pain and is targeted by the therapy with bone marrow stromal cells.
    6. he transcription factor Yy1 regulates sST2 expression, and repression of Yy1 by metformin results in lower levels of sST2 that are associated with favorable myocardial remodeling. The manipulation of YY1 or its co-repressor HDAC4 emerge as new targets to modulate ST2/IL33 signaling and prevent adverse cardiac remodeling.
      Title: Yin-Yang 1 transcription factor modulates ST2 expression during adverse cardiac remodeling post-myocardial infarction.
    7. Calycosin treatment markedly improved the aforementioned makers of renal injury and dysfunction, modulated IL33/ST2 signaling.
      Title: Renoprotective effect of calycosin in high fat diet-fed/STZ injected rats: Effect on IL-33/ST2 signaling, oxidative stress and fibrosis suppression.
    8. The lungs are a relevant source of sST2 in heart failure, shich may have implications for disease progression.
      Title: Pulmonary Production of Soluble ST2 in Heart Failure.
    9. ST2/IL-33 signaling plays an important role in the development of radicular pain in lumbar disk herniation.
      Title: IL-33/ST2 signaling contributes to radicular pain by modulating MAPK and NF-κB activation and inflammatory mediator expression in the spinal cord in rat models of noncompressive lumber disk herniation.
    10. administration of sST2 significantly attenuated the severity of severe acute pancreatitis and associated cardiac damage, and the cardioprotective effect is associated with its anti-inflammatory action
      Title: Adenovirus-mediated overexpression of sST2 attenuates cardiac injury in the rat with severe acute pancreatitis.
    Submit: New GeneRIF Correction See all GeneRIFs (15)

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables NAD+ nucleosidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NAD+ nucleotidase, cyclic ADP-ribose generating IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables interleukin-1 receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables interleukin-33 binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables interleukin-33 binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables interleukin-33 binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables interleukin-33 receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables interleukin-33 receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to mechanical stimulus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in cellular response to peptide IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in inflammatory response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in inflammatory response ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in interleukin-33-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in interleukin-33-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in interleukin-33-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in macrophage differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in macrophage differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in macrophage differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of T-helper 1 type immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of T-helper 1 type immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cell population proliferation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of type II interferon production IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of type II interferon production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of chemokine production IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of chemokine production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of inflammatory response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of inflammatory response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of interleukin-5 production IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of interleukin-5 production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of macrophage activation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of macrophage activation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to nutrient levels IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in external side of plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in external side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in focal adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in focal adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    interleukin-1 receptor-like 1
    Names
    fos-responsive gene 1 protein
    NP_001121161.1
    NP_037169.1
    XP_006244801.1
    XP_006244802.1
    XP_008765214.1
    XP_017451779.1
    XP_038938998.1
    XP_038938999.1
    XP_038939000.1
    XP_038939001.1
    XP_063122776.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001127689.1 → NP_001121161.1  interleukin-1 receptor-like 1 isoform Fit-1M precursor

      See identical proteins and their annotated locations for NP_001121161.1

      Status: PROVISIONAL

      Source sequence(s)
      U04317
      UniProtKB/Swiss-Prot
      Q62611, Q62612
      UniProtKB/TrEMBL
      F1LR63
      Conserved Domains (4) summary
      cd05757
      Location:123 → 210
      Ig2_IL1R_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
      smart00410
      Location:31 → 110
      IG_like; Immunoglobulin like
      pfam01582
      Location:384 → 539
      TIR; TIR domain
      cl11960
      Location:28 → 110
      Ig; Immunoglobulin domain

    2. NM_013037.1 → NP_037169.1  interleukin-1 receptor-like 1 isoform Fit-1S precursor

      See identical proteins and their annotated locations for NP_037169.1

      Status: PROVISIONAL

      Source sequence(s)
      U04319
      UniProtKB/Swiss-Prot
      Q62611
      Related
      ENSRNOP00000103721.1, ENSRNOT00000136818.1
      Conserved Domains (3) summary
      cd05757
      Location:123 → 210
      Ig2_IL1R_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
      smart00410
      Location:31 → 110
      IG_like; Immunoglobulin like
      cl11960
      Location:28 → 110
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      50157326..50222888
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039083070.2 → XP_038938998.1  interleukin-1 receptor-like 1 isoform X1

      UniProtKB/TrEMBL
      F1LR63
      Conserved Domains (4) summary
      pfam01582
      Location:384 → 539
      TIR; TIR domain
      cd00096
      Location:37 → 42
      Ig; Ig strand B [structural motif]
      cd05757
      Location:123 → 210
      Ig2_IL1R-like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains
      cl11960
      Location:33 → 110
      Ig; Immunoglobulin domain

    2. XM_039083072.2 → XP_038939000.1  interleukin-1 receptor-like 1 isoform X1

      UniProtKB/TrEMBL
      F1LR63
      Related
      ENSRNOP00000020108.5, ENSRNOT00000020108.7
      Conserved Domains (4) summary
      pfam01582
      Location:384 → 539
      TIR; TIR domain
      cd00096
      Location:37 → 42
      Ig; Ig strand B [structural motif]
      cd05757
      Location:123 → 210
      Ig2_IL1R-like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains
      cl11960
      Location:33 → 110
      Ig; Immunoglobulin domain

    3. XM_008766992.4 → XP_008765214.1  interleukin-1 receptor-like 1 isoform X1

      See identical proteins and their annotated locations for XP_008765214.1

      UniProtKB/TrEMBL
      F1LR63
      Conserved Domains (4) summary
      pfam01582
      Location:384 → 539
      TIR; TIR domain
      cd00096
      Location:37 → 42
      Ig; Ig strand B [structural motif]
      cd05757
      Location:123 → 210
      Ig2_IL1R-like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains
      cl11960
      Location:33 → 110
      Ig; Immunoglobulin domain

    4. XM_006244740.5 → XP_006244802.1  interleukin-1 receptor-like 1 isoform X1

      See identical proteins and their annotated locations for XP_006244802.1

      UniProtKB/TrEMBL
      F1LR63
      Conserved Domains (4) summary
      pfam01582
      Location:384 → 539
      TIR; TIR domain
      cd00096
      Location:37 → 42
      Ig; Ig strand B [structural motif]
      cd05757
      Location:123 → 210
      Ig2_IL1R-like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains
      cl11960
      Location:33 → 110
      Ig; Immunoglobulin domain

    5. XM_063266706.1 → XP_063122776.1  interleukin-1 receptor-like 1 isoform X1

      UniProtKB/TrEMBL
      F1LR63

    6. XM_006244739.5 → XP_006244801.1  interleukin-1 receptor-like 1 isoform X1

      See identical proteins and their annotated locations for XP_006244801.1

      UniProtKB/TrEMBL
      F1LR63
      Conserved Domains (4) summary
      pfam01582
      Location:384 → 539
      TIR; TIR domain
      cd00096
      Location:37 → 42
      Ig; Ig strand B [structural motif]
      cd05757
      Location:123 → 210
      Ig2_IL1R-like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains
      cl11960
      Location:33 → 110
      Ig; Immunoglobulin domain

    7. XM_039083071.2 → XP_038938999.1  interleukin-1 receptor-like 1 isoform X1

      UniProtKB/TrEMBL
      F1LR63
      Conserved Domains (4) summary
      pfam01582
      Location:384 → 539
      TIR; TIR domain
      cd00096
      Location:37 → 42
      Ig; Ig strand B [structural motif]
      cd05757
      Location:123 → 210
      Ig2_IL1R-like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains
      cl11960
      Location:33 → 110
      Ig; Immunoglobulin domain

    8. XM_017596290.3 → XP_017451779.1  interleukin-1 receptor-like 1 isoform X1

      UniProtKB/TrEMBL
      F1LR63
      Conserved Domains (4) summary
      pfam01582
      Location:384 → 539
      TIR; TIR domain
      cd00096
      Location:37 → 42
      Ig; Ig strand B [structural motif]
      cd05757
      Location:123 → 210
      Ig2_IL1R-like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains
      cl11960
      Location:33 → 110
      Ig; Immunoglobulin domain

    9. XM_039083073.2 → XP_038939001.1  interleukin-1 receptor-like 1 isoform X1

      UniProtKB/TrEMBL
      F1LR63
      Conserved Domains (4) summary
      pfam01582
      Location:384 → 539
      TIR; TIR domain
      cd00096
      Location:37 → 42
      Ig; Ig strand B [structural motif]
      cd05757
      Location:123 → 210
      Ig2_IL1R-like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R), and similar domains
      cl11960
      Location:33 → 110
      Ig; Immunoglobulin domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q62611.1 GenPept UniProtKB/Swiss-Prot:Q62611

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