Strn3 striatin 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Strn3provided by RGD
Official Full Name: striatin 3provided by RGD
Primary source: RGD:621827
See related: EnsemblRapid:ENSRNOG00000060335 AllianceGenome:RGD:621827
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Gs2na; Sg2na
Summary: Predicted to enable several functions, including armadillo repeat domain binding activity; calmodulin binding activity; and enzyme binding activity. Involved in negative regulation of DNA-templated transcription; negative regulation of intracellular estrogen receptor signaling pathway; and response to estradiol. Located in dendrite and neuronal cell body. Part of protein-containing complex. Orthologous to human STRN3 (striatin 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Muscle (RPKM 465.8), Heart (RPKM 328.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 6q23

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (74783156..74869473, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (69047776..69134102, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (72376360..72462676, complement)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

In the Rat Midbrain, SG2NA and DJ-1 have Common Interactome, Including Mitochondrial Electron Transporters that are Comodulated Under Oxidative Stress.
Title: In the Rat Midbrain, SG2NA and DJ-1 have Common Interactome, Including Mitochondrial Electron Transporters that are Comodulated Under Oxidative Stress.
A rat STRN3 gamma-protein phosphatase 2A complex is recruited to agonist-activated estrogen receptor alpha, thereby leading to its dephosphorylation and inhibiting transcription.
Title: Striatin-3 gamma inhibits estrogen receptor activity by recruiting a protein phosphatase.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:236842

BE107927 (e-PCR)
- UniSTS:247118

d6rat130 (e-PCR)
- UniSTS:122206

AI228304 (e-PCR)
- UniSTS:261582

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables armadillo repeat domain binding	ISO Inferred from Sequence Orthology more info
enables calmodulin binding	IBA Inferred from Biological aspect of Ancestor more info
enables calmodulin binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein phosphatase 2A binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein phosphatase 2A binding	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein-containing complex binding	IDA Inferred from Direct Assay more info	PubMed
enables protein-containing complex binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables protein-macromolecule adaptor activity	ISO Inferred from Sequence Orthology more info
enables protein-macromolecule adaptor activity	ISS Inferred from Sequence or Structural Similarity more info
enables small GTPase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in negative regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of hippo signaling	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of hippo signaling	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of intracellular estrogen receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of intracellular estrogen receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in response to estradiol	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
part_of FAR/SIN/STRIPAK complex	IBA Inferred from Biological aspect of Ancestor more info
part_of FAR/SIN/STRIPAK complex	ISO Inferred from Sequence Orthology more info
part_of FAR/SIN/STRIPAK complex	ISS Inferred from Sequence or Structural Similarity more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in dendrite	IBA Inferred from Biological aspect of Ancestor more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in postsynapse	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: striatin-3

Names: cell cycle autoantigen SG2NA; nuclear autoantigen; s/G2 antigen; striatin, calmodulin binding protein 3; striatin-3-gamma

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001029897.3 → NP_001025068.1 striatin-3

See identical proteins and their annotated locations for NP_001025068.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000006

UniProtKB/Swiss-Prot

P58405

Related

ENSRNOP00000074395.1, ENSRNOT00000077578.3

Conserved Domains (4) summary

COG2319
Location:463 → 792

WD40; WD40 repeat [General function prediction only]

cd00200
Location:472 → 793

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

pfam08232
Location:63 → 188

Striatin; Striatin family

sd00039
Location:482 → 528

7WD40; WD40 repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086024.1 Reference GRCr8

Range

74783156..74869473 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006240077.4 → XP_006240139.1 striatin-3 isoform X3

UniProtKB/TrEMBL

E9PT82

Related

ENSRNOP00000071600.1, ENSRNOT00000088720.3

Conserved Domains (4) summary

COG2319
Location:379 → 708

WD40; WD40 repeat [General function prediction only]

cd00200
Location:388 → 709

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

pfam08232
Location:63 → 188

Striatin; Striatin family

sd00039
Location:398 → 444

7WD40; WD40 repeat [structural motif]
XM_006240075.4 → XP_006240137.1 striatin-3 isoform X1

UniProtKB/TrEMBL

A0A8I6AGH7

Related

ENSRNOP00000087402.1, ENSRNOT00000106600.2

Conserved Domains (4) summary

COG2319
Location:426 → 755

WD40; WD40 repeat [General function prediction only]

cd00200
Location:435 → 756

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

pfam08232
Location:63 → 188

Striatin; Striatin family

sd00039
Location:445 → 491

7WD40; WD40 repeat [structural motif]
XM_006240076.4 → XP_006240138.1 striatin-3 isoform X2

UniProtKB/TrEMBL

A0A8I5ZUH2

Related

ENSRNOP00000081686.1, ENSRNOT00000111997.2

Conserved Domains (4) summary

COG2319
Location:320 → 745

WD40; WD40 repeat [General function prediction only]

cd00200
Location:425 → 746

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

pfam08232
Location:63 → 188

Striatin; Striatin family

sd00039
Location:435 → 481

7WD40; WD40 repeat [structural motif]