Nmnat2 nicotinamide nucleotide adenylyltransferase 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Nmnat2provided by RGD
Official Full Name: nicotinamide nucleotide adenylyltransferase 2provided by RGD
Primary source: RGD:1307331
See related: EnsemblRapid:ENSRNOG00000027697 AllianceGenome:RGD:1307331
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable nicotinamide-nucleotide adenylyltransferase activity; nicotinate-nucleotide adenylyltransferase activity; and protein ADP-ribosyltransferase-substrate adaptor activity. Involved in NAD biosynthetic process and cellular response to angiotensin. Predicted to be located in several cellular components, including cytosol; late endosome; and trans-Golgi network. Predicted to be active in Golgi apparatus. Biomarker of hypertrophic cardiomyopathy. Orthologous to human NMNAT2 (nicotinamide nucleotide adenylyltransferase 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 184.4), Lung (RPKM 21.7) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 13q21

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (67655794..67831609)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (65105950..65277350)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (70379346..70559311)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Dysbiosis of gut microbiota inhibits NMNAT2 to promote neurobehavioral deficits and oxidative stress response in the 6-OHDA-lesioned rat model of Parkinson's disease.
Title: Dysbiosis of gut microbiota inhibits NMNAT2 to promote neurobehavioral deficits and oxidative stress response in the 6-OHDA-lesioned rat model of Parkinson's disease.
Data show that overexpression of Nmnat2 but not its catalytically inactive mutant blocked angiotensin II (Ang II)-induced cardiac hypertrophy, which was dependent on activation of SIRT6 through maintaining the intracellular NAD level.
Title: Nmnat2 protects cardiomyocytes from hypertrophy via activation of SIRT6.

Submit: New GeneRIF Correction

General gene information

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Markers

BE101794 (e-PCR)
- UniSTS:243715

D13Rat196 (e-PCR), detects polymorphism
- UniSTS:226571

D13Rat61 (e-PCR), detects polymorphism
- UniSTS:226579

BF388095 (e-PCR)
- UniSTS:260899

RH139296 (e-PCR)
- UniSTS:221382

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables nicotinamide-nucleotide adenylyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables nicotinamide-nucleotide adenylyltransferase activity	IEA Inferred from Electronic Annotation more info
enables nicotinate-nucleotide adenylyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables nicotinate-nucleotide adenylyltransferase activity	IEA Inferred from Electronic Annotation more info
enables nicotinate-nucleotide adenylyltransferase activity	ISO Inferred from Sequence Orthology more info
enables protein ADP-ribosyltransferase-substrate adaptor activity	IEA Inferred from Electronic Annotation more info
enables protein ADP-ribosyltransferase-substrate adaptor activity	ISO Inferred from Sequence Orthology more info
enables protein ADP-ribosyltransferase-substrate adaptor activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in NAD biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in NAD biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in NAD biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in cellular response to angiotensin	IEP Inferred from Expression Pattern more info	PubMed
involved_in negative regulation of cytoplasmic translation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cytoplasmic translation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in axon	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic vesicle membrane	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in late endosome	ISO Inferred from Sequence Orthology more info
located_in synapse	ISO Inferred from Sequence Orthology more info
located_in trans-Golgi network	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2

Names: NMN adenylyltransferase 2; NMN/NaMN adenylyltransferase 2; naMN adenylyltransferase 1; naMN adenylyltransferase 2; nicotinamide mononucleotide adenylyltransferase 2; nicotinate-nucleotide adenylyltransferase 1; nicotinate-nucleotide adenylyltransferase 2

NP_001041507.1

EC 2.7.7.1

EC 2.7.7.18

XP_063128171.1

EC 2.7.7.1

EC 2.7.7.18

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001048042.1 → NP_001041507.1 nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2

See identical proteins and their annotated locations for NP_001041507.1

Status: PROVISIONAL

Source sequence(s)

DQ022370

UniProtKB/Swiss-Prot

Q0HA29

UniProtKB/TrEMBL

F1LPZ7

Related

ENSRNOP00000029020.5, ENSRNOT00000038183.7

Conserved Domains (1) summary

cd09286
Location:9 → 302

NMNAT_Eukarya; Nicotinamide/nicotinate mononucleotide adenylyltransferase, Eukaryotic