Slc17a5 solute carrier family 17 member 5 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slc17a5provided by RGD
Official Full Name: solute carrier family 17 member 5provided by RGD
Primary source: RGD:1311388
See related: EnsemblRapid:ENSRNOG00000090360 AllianceGenome:RGD:1311388
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: AST; VEAT
Summary: Enables sialic acid transmembrane transporter activity. Involved in sialic acid transport. Predicted to be located in cytoplasmic vesicle; cytosol; and plasma membrane. Predicted to be active in apical plasma membrane; bounding membrane of organelle; and glutamatergic synapse. Human ortholog(s) of this gene implicated in sialuria. Orthologous to human SLC17A5 (solute carrier family 17 member 5). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 116.7), Liver (RPKM 45.4) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q31

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (88274497..88309734, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (79394416..79429387, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (85891245..85926466, complement)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Sialin mediates submandibular gland regeneration ability by affecting polysialic acid synthesis.
Title: Sialin mediates submandibular gland regeneration ability by affecting polysialic acid synthesis.
l-aspartate is exocytotically released from nerve terminals after vesicular accumulation by a transporter other than sialin.
Title: Vesicular uptake and exocytosis of L-aspartate is independent of sialin.
analysis of crucial residues and substrate-induced conformational changes in SLC17 transporter sialin
Title: Structure-function studies of the SLC17 transporter sialin identify crucial residues and substrate-induced conformational changes.
sialin possesses dual physiological functions and acts as a vesicular aspartate/glutamate transporter
Title: Identification of a vesicular aspartate transporter.

Submit: New GeneRIF Correction

General gene information

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Markers

D8Rat22 (e-PCR)
- UniSTS:119090

RH128569 (e-PCR)
- UniSTS:211877

RH138504 (e-PCR)
- UniSTS:220591

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables D-glucuronate transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables sialic acid transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables sialic acid transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables sialic acid transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables symporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in D-glucuronate transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in neurotransmitter loading into synaptic vesicle	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to bacterium	ISO Inferred from Sequence Orthology more info
involved_in sialic acid transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in sialic acid transport	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within sialic acid transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in apical plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in basolateral plasma membrane	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic vesicle	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
is_active_in lysosomal membrane	ISO Inferred from Sequence Orthology more info
located_in lysosomal membrane	ISO Inferred from Sequence Orthology more info
is_active_in lysosome	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in synaptic vesicle membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: sialin

Names: H(+)/nitrate cotransporter; H(+)/sialic acid cotransporter; proton-coupled sialic acid transporter; solute carrier family 17 (acidic sugar transporter), member 5; solute carrier family 17 (anion/sugar transporter), member 5; vesicular excitatory amino acid transporter

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001009713.2 → NP_001009713.1 sialin

See identical proteins and their annotated locations for NP_001009713.1

Status: PROVISIONAL

Source sequence(s)

BC097482

UniProtKB/Swiss-Prot

Q5Q0U0

Related

ENSRNOP00000098782.1, ENSRNOT00000141108.1

Conserved Domains (2) summary

cd06174
Location:99 → 478

MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

TIGR00894
Location:30 → 491

2A0114euk; Na(+)-dependent inorganic phosphate cotransporter