Rapgefl1 Rap guanine nucleotide exchange factor like 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Rapgefl1provided by RGD
Official Full Name: Rap guanine nucleotide exchange factor like 1provided by RGD
Primary source: RGD:1563269
See related: EnsemblRapid:ENSRNOG00000027871 AllianceGenome:RGD:1563269
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in small GTPase-mediated signal transduction. Orthologous to human RAPGEFL1 (Rap guanine nucleotide exchange factor like 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 85.4), Kidney (RPKM 12.6) and 3 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q31

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (84289980..84306614)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (83793711..83810373)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (86749220..86765677)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables guanyl-nucleotide exchange factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables guanyl-nucleotide exchange factor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in Ras protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in small GTPase-mediated signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: rap guanine nucleotide exchange factor-like 1

Names: Rap guanine nucleotide exchange factor (GEF)-like 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001427833.1 → NP_001414762.1 rap guanine nucleotide exchange factor-like 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

UniProtKB/TrEMBL

A0A8J8XFA0

Related

ENSRNOP00000036373.6, ENSRNOT00000030425.7

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

84289980..84306614

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039087397.2 → XP_038943325.1 rap guanine nucleotide exchange factor-like 1 isoform X1

Conserved Domains (1) summary

smart00147
Location:245 → 483

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases