U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Cd69 Cd69 molecule [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29187, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Cd69provided by RGD
    Official Full Name
    Cd69 moleculeprovided by RGD
    Primary source
    RGD:61318
    See related
    EnsemblRapid:ENSRNOG00000056783 AllianceGenome:RGD:61318
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables calcium ion binding activity. Predicted to be involved in cellular response to xenobiotic stimulus; negative regulation of T cell migration; and negative regulation of T-helper 17 cell lineage commitment. Predicted to be located in cell surface. Predicted to be part of protein-containing complex. Predicted to be active in external side of plasma membrane. Orthologous to human CD69 (CD69 molecule). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 246.4), Spleen (RPKM 80.1) and 2 other tissues See more
    Orthologs
    human all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Cd69 in Genome Data Viewer
    Location:
    4q42
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (164411485..164419403, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (162725446..162733364, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (163041147..163049065, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene C-type lectin domain family 2, member G Neighboring gene uncharacterized LOC100909928 Neighboring gene C-type lectin domain family 2, member M Neighboring gene C-type lectin domain family 12, member A Neighboring gene chromatin target of PRMT1-like 1

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Lymphocyte activation receptors: new structural paradigms in group V of C-type animal lectins. Pavlícek J, et al. Biochem Soc Trans, 2004 Dec. PMID 15506986
    2. Functional analysis of ligand-binding and signal transduction domains of CD69 and CD23 C-type lectin leukocyte receptors. Sancho D, et al. J Immunol, 2000 Oct 1. PMID 11034393
    3. Crystal structure of human CD69: a C-type lectin-like activation marker of hematopoietic cells. Natarajan K, et al. Biochemistry, 2000 Dec 5. PMID 11101293
    4. Mitogenic signals through CD28 activate the protein kinase Ctheta-NF-kappaB pathway in primary peripheral T cells. Dennehy KM, et al. Int Immunol, 2003 May. PMID 12697665
    5. Expression of interleukin-10 in intestinal lymphocytes detected by an interleukin-10 reporter knockin tiger mouse. Kamanaka M, et al. Immunity, 2006 Dec. PMID 17137799

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calcium ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables molecular sequestering activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transmembrane signaling receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to xenobiotic stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in complement activation, lectin pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in negative regulation of T cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of T-helper 17 cell lineage commitment ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in external side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    C-type lectin domain family 2 member A
    Names
    CD69 antigen
    early activation antigen CD69

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_134327.2 → NP_599154.1  C-type lectin domain family 2 member A

      See identical proteins and their annotated locations for NP_599154.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/TrEMBL
      A0A8I6G1Q9, D9Z4I9, Q5M851
      Related
      ENSRNOP00000105129.1, ENSRNOT00000153540.1
      Conserved Domains (1) summary
      cd03593
      Location:85 → 196
      CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      164411485..164419403 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools