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    Dhx36 DEAH-box helicase 36 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 310461, updated on 9-Dec-2024

    Summary

    Official Symbol
    Dhx36provided by RGD
    Official Full Name
    DEAH-box helicase 36provided by RGD
    Primary source
    RGD:1308767
    See related
    EnsemblRapid:ENSRNOG00000014599 AllianceGenome:RGD:1308767
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    G4R1
    Summary
    Enables pre-miRNA binding activity. Involved in positive regulation of dendritic spine morphogenesis; positive regulation of gene expression; and positive regulation of intracellular mRNA localization. Located in axon; dendrite; and perikaryon. Orthologous to human DHX36 (DEAH-box helicase 36). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 198.3), Thymus (RPKM 189.5) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Dhx36 in Genome Data Viewer
    Location:
    2q31
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (149006089..149044192, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (146856469..146894577, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (152785844..152824549, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA48 Neighboring gene Rho guanine nucleotide exchange factor 26 Neighboring gene uncharacterized LOC134485922 Neighboring gene uncharacterized LOC120100834 Neighboring gene G protein-coupled receptor 149 Neighboring gene RNA, U6 small nuclear 1286

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Items 1 - 25 of 46
    Function Evidence Code Pubs
    enables ATP binding  
    enables ATP binding  
    enables ATP hydrolysis activity  
    enables ATP-dependent H2AZ histone chaperone activity  
    enables ATP-dependent H3-H4 histone complex chaperone activity  
    enables ATP-dependent activity, acting on DNA  
    enables DNA clamp loader activity  
    enables DNA helicase activity  
    enables DNA helicase activity  
    enables DNA helicase activity  
    enables G-quadruplex DNA binding  
    enables G-quadruplex DNA binding  
    enables G-quadruplex DNA binding  
    enables G-quadruplex RNA binding  
    enables G-quadruplex RNA binding  
    enables G-quadruplex RNA binding  
    enables RNA binding  
    enables RNA binding  
    enables RNA helicase activity  
    enables RNA helicase activity  
    enables RNA helicase activity  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding  
    enables chromatin extrusion motor activity  
    enables cohesin loader activity  
    enables double-stranded DNA helicase activity  
    enables double-stranded RNA binding  
    enables forked DNA-dependent helicase activity  
    enables four-way junction helicase activity  
    enables helicase activity  
    enables histone deacetylase binding  
    enables hydrolase activity  
    enables mRNA 3'-UTR AU-rich region binding  
    enables mRNA 3'-UTR AU-rich region binding  
    enables mRNA 3'-UTR binding  
    enables mRNA 3'-UTR binding  
    enables mRNA 5'-UTR binding  
    enables mRNA 5'-UTR binding  
    enables magnesium ion binding  
    enables magnesium ion binding  
    enables pre-miRNA binding PubMed 
    enables single-stranded 3'-5' DNA helicase activity  
    enables single-stranded DNA binding  
    enables telomerase RNA binding  
    enables telomerase RNA binding  
    enables transcription cis-regulatory region binding  
    Items 1 - 25 of 46
    Items 1 - 25 of 52
    Process Evidence Code Pubs
    involved_in 3'-UTR-mediated mRNA destabilization  
    involved_in 3'-UTR-mediated mRNA destabilization  
    involved_in DNA duplex unwinding  
    involved_in G-quadruplex DNA unwinding  
    involved_in G-quadruplex DNA unwinding  
    involved_in RNA secondary structure unwinding  
    involved_in RNA secondary structure unwinding  
    involved_in cell differentiation  
    involved_in cellular response to UV  
    involved_in cellular response to UV  
    involved_in cellular response to arsenite ion  
    involved_in cellular response to heat  
    involved_in chromatin looping  
    involved_in chromatin remodeling  
    involved_in defense response to virus  
    involved_in innate immune response  
    involved_in negative regulation of translation  
    involved_in negative regulation of translation  
    involved_in ossification  
    involved_in positive regulation of canonical NF-kappaB signal transduction  
    involved_in positive regulation of canonical NF-kappaB signal transduction  
    involved_in positive regulation of cardioblast differentiation  
    involved_in positive regulation of cardioblast differentiation  
    involved_in positive regulation of cytoplasmic translation  
    involved_in positive regulation of cytoplasmic translation  
    involved_in positive regulation of dendritic spine morphogenesis PubMed 
    involved_in positive regulation of gene expression PubMed 
    involved_in positive regulation of hematopoietic progenitor cell differentiation  
    involved_in positive regulation of hematopoietic progenitor cell differentiation  
    involved_in positive regulation of interferon-alpha production  
    involved_in positive regulation of intracellular mRNA localization PubMed 
    involved_in positive regulation of mRNA 3'-end processing  
    involved_in positive regulation of mRNA 3'-end processing  
    involved_in positive regulation of myeloid dendritic cell cytokine production  
    involved_in positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay  
    involved_in positive regulation of telomere maintenance  
    involved_in positive regulation of telomere maintenance via telomere lengthening  
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in positive regulation of transcription by RNA polymerase II  
    involved_in positive regulation of transcription initiation by RNA polymerase II  
    involved_in positive regulation of transcription initiation by RNA polymerase II  
    involved_in regulation of embryonic development  
    involved_in regulation of embryonic development  
    involved_in regulation of mRNA stability  
    involved_in regulation of mRNA stability  
    involved_in regulation of transcription by RNA polymerase III  
    involved_in regulation of transcription by RNA polymerase III  
    acts_upstream_of_or_within response to exogenous dsRNA  
    acts_upstream_of_or_within response to virus  
    involved_in spermatogenesis  
    involved_in spermatogenesis  
    involved_in telomerase RNA stabilization  
    Items 1 - 25 of 52
    Component Evidence Code Pubs
    located_in axon PubMed 
    located_in chromosome, telomeric region  
    located_in chromosome, telomeric region  
    is_active_in cytoplasm  
    located_in cytoplasm  
    located_in cytoplasm  
    located_in cytoplasmic stress granule  
    located_in cytosol  
    located_in cytosol  
    located_in dendrite PubMed 
    located_in mitochondrion  
    located_in mitochondrion  
    located_in nuclear speck  
    located_in nuclear speck  
    located_in nucleoplasm  
    is_active_in nucleus  
    located_in nucleus  
    located_in nucleus  
    located_in perikaryon PubMed 

    General protein information

    Preferred Names
    ATP-dependent DNA/RNA helicase DHX36
    Names
    ATP-dependent RNA helicase DHX36
    DEAD/H box polypeptide 36
    DEAH (Asp-Glu-Ala-His) box polypeptide 36
    DEAH-box protein 36
    G4-resolvase-1
    MLE-like protein 1
    RNA helicase associated with AU-rich element protein
    probable ATP-dependent RNA helicase DHX36
    NP_001101148.1
    XP_008759269.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107678.3NP_001101148.1  ATP-dependent DNA/RNA helicase DHX36

      See identical proteins and their annotated locations for NP_001101148.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/Swiss-Prot
      D4A2Z8
      UniProtKB/TrEMBL
      A0A8I6A6W1
      Related
      ENSRNOP00000019824.5, ENSRNOT00000019824.8
      Conserved Domains (1) summary
      COG1643
      Location:187893
      HrpA; HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      149006089..149044192 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008761047.4XP_008759269.1  ATP-dependent DNA/RNA helicase DHX36 isoform X1

      Conserved Domains (4) summary
      smart00487
      Location:202384
      DEXDc; DEAD-like helicases superfamily
      smart00847
      Location:668752
      HA2; Helicase associated domain (HA2) Add an annotation
      cd00046
      Location:216361
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      pfam00271
      Location:470598
      Helicase_C; Helicase conserved C-terminal domain

    RNA

    1. XR_005500288.2 RNA Sequence

    2. XR_351724.5 RNA Sequence

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