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    Csnk1g1 casein kinase 1, gamma 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 64086, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Csnk1g1provided by RGD
    Official Full Name
    casein kinase 1, gamma 1provided by RGD
    Primary source
    RGD:621404
    See related
    EnsemblRapid:ENSRNOG00000016620 AllianceGenome:RGD:621404
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables protein serine/threonine kinase activity. Involved in protein autophosphorylation. Predicted to be located in cytosol. Predicted to be active in cytoplasm; nucleus; and plasma membrane. Orthologous to human CSNK1G1 (casein kinase 1 gamma 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 67.1), Adrenal (RPKM 66.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Csnk1g1 in Genome Data Viewer
    Location:
    8q24
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (75334751..75472339)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (66439760..66577247)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (71533372..71688483)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene zinc finger protein 609 Neighboring gene thyroid hormone receptor interactor 4 Neighboring gene U6 spliceosomal RNA Neighboring gene PCNA clamp associated factor Neighboring gene small nucleolar RNA SNORA17 Neighboring gene sorting nexin 22 Neighboring gene peptidylprolyl isomerase B Neighboring gene sorting nexin 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Casein kinase I gamma subfamily. Molecular cloning, expression, and characterization of three mammalian isoforms and complementation of defects in the Saccharomyces cerevisiae YCK genes. Zhai L, et al. J Biol Chem, 1995 May 26. PMID 7759525
    2. Wnt signalling and its impact on development and cancer. Klaus A, et al. Nat Rev Cancer, 2008 May. PMID 18432252
    3. Phosphorylation of LRRK2 by casein kinase 1α regulates trans-Golgi clustering via differential interaction with ARHGEF7. Chia R, et al. Nat Commun, 2014 Dec 15. PMID 25500533, Free PMC Article
    4. Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis. Na CH, et al. J Proteome Res, 2012 Sep 7. PMID 22871113, Free PMC Article
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables AMP-activated protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables Rho-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables eukaryotic translation initiation factor 2alpha kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS121 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AT120 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AXS139 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS14 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS36 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S10 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S28 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S57 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T11 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T3 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T45 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H4S1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ribosomal protein S6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein autophosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    casein kinase I isoform gamma-1; casein kinase I
    Names
    CKI-gamma 1
    NP_071624.1
    XP_008764554.1
    XP_008764556.1
    XP_008764557.1
    XP_017451375.1
    XP_017451379.1
    XP_017451380.1
    XP_017451381.1
    XP_038938002.1
    XP_038938003.1
    XP_038938005.1
    XP_038938006.1
    XP_038938007.1
    XP_063122140.1
    XP_063122141.1
    XP_063122142.1
    XP_063122143.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001431618.1 → NP_001418547.1  casein kinase I isoform gamma-1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A0A8I5ZUI8, A6J5G7

    2. NM_001431619.1 → NP_001418548.1  casein kinase I isoform gamma-1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A0A8I5ZUI8, A6J5G7

    3. NM_001431620.1 → NP_001418549.1  casein kinase I isoform gamma-1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A0A8I5ZUI8, A6J5G7

    4. NM_001431621.1 → NP_001418550.1  casein kinase I isoform gamma-1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A0A8I5ZUI8, A6J5G7

    5. NM_001431622.1 → NP_001418551.1  casein kinase I isoform gamma-1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A0A8I5ZUI8, A6J5G7

    6. NM_001431623.1 → NP_001418552.1  casein kinase I isoform gamma-1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A0A0G2K7C4

    7. NM_001431624.1 → NP_001418553.1  casein kinase I isoform gamma-1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A0A0G2K7C4

    8. NM_001431625.1 → NP_001418554.1  casein kinase I isoform gamma-1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008

    9. NM_001431626.1 → NP_001418555.1  casein kinase I isoform gamma-1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008

    10. NM_001431628.1 → NP_001418557.1  casein kinase I isoform gamma-1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008

    11. NM_001431629.1 → NP_001418558.1  casein kinase I isoform gamma-1 isoform 5

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/Swiss-Prot
      Q62761
      UniProtKB/TrEMBL
      A6J5G8

    12. NM_022288.3 → NP_071624.1  casein kinase I isoform gamma-1 isoform 5

      See identical proteins and their annotated locations for NP_071624.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/Swiss-Prot
      Q62761
      UniProtKB/TrEMBL
      A6J5G8
      Related
      ENSRNOP00000048274.2, ENSRNOT00000042369.5
      Conserved Domains (3) summary
      COG0515
      Location:43 → 266
      SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
      cd14126
      Location:43 → 331
      STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
      pfam12605
      Location:331 → 387
      CK1gamma_C; Casein kinase 1 gamma C terminal

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      75334751..75472339
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017595886.3 → XP_017451375.1  casein kinase I isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZWD5
      Related
      ENSRNOP00000082115.2, ENSRNOT00000116171.2
      Conserved Domains (2) summary
      cd14126
      Location:43 → 331
      STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
      pfam12605
      Location:331 → 429
      CK1gamma_C; Casein kinase 1 gamma C terminal

    2. XM_008766332.4 → XP_008764554.1  casein kinase I isoform X2

      Related
      ENSRNOP00000082082.2, ENSRNOT00000096791.2
      Conserved Domains (3) summary
      COG0515
      Location:43 → 396
      SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
      cd14126
      Location:43 → 331
      STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
      pfam12605
      Location:331 → 418
      CK1gamma_C; Casein kinase 1 gamma C terminal

    3. XM_017595891.3 → XP_017451380.1  casein kinase I isoform X3

      UniProtKB/TrEMBL
      A0A8I6AAK7
      Related
      ENSRNOP00000090680.1, ENSRNOT00000096879.2

    4. XM_008766335.4 → XP_008764557.1  casein kinase I isoform X5

      Conserved Domains (3) summary
      COG0515
      Location:43 → 266
      SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
      cd14126
      Location:43 → 331
      STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
      pfam12605
      Location:331 → 381
      CK1gamma_C; Casein kinase 1 gamma C terminal

    5. XM_008766334.4 → XP_008764556.1  casein kinase I isoform X4

      Conserved Domains (3) summary
      COG0515
      Location:43 → 426
      SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
      cd14126
      Location:43 → 331
      STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
      pfam12605
      Location:331 → 411
      CK1gamma_C; Casein kinase 1 gamma C terminal

    6. XM_017595892.3 → XP_017451381.1  casein kinase I isoform X6

      Conserved Domains (3) summary
      COG0515
      Location:43 → 266
      SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
      cd14126
      Location:43 → 331
      STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
      pfam12605
      Location:331 → 387
      CK1gamma_C; Casein kinase 1 gamma C terminal

    7. XM_039082075.2 → XP_038938003.1  casein kinase I isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZWD5
      Conserved Domains (2) summary
      cd14126
      Location:43 → 331
      STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
      pfam12605
      Location:331 → 429
      CK1gamma_C; Casein kinase 1 gamma C terminal

    8. XM_039082074.2 → XP_038938002.1  casein kinase I isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZWD5
      Conserved Domains (2) summary
      cd14126
      Location:43 → 331
      STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
      pfam12605
      Location:331 → 429
      CK1gamma_C; Casein kinase 1 gamma C terminal

    9. XM_039082077.2 → XP_038938005.1  casein kinase I isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZWD5
      Conserved Domains (2) summary
      cd14126
      Location:43 → 331
      STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
      pfam12605
      Location:331 → 429
      CK1gamma_C; Casein kinase 1 gamma C terminal

    10. XM_063266071.1 → XP_063122141.1  casein kinase I isoform X2

    11. XM_063266070.1 → XP_063122140.1  casein kinase I isoform X2

    12. XM_063266073.1 → XP_063122143.1  casein kinase I isoform X5

    13. XM_017595890.3 → XP_017451379.1  casein kinase I isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZWD5
      Conserved Domains (2) summary
      cd14126
      Location:43 → 331
      STKc_CK1_gamma; Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1 gamma
      pfam12605
      Location:331 → 429
      CK1gamma_C; Casein kinase 1 gamma C terminal

    14. XM_063266072.1 → XP_063122142.1  casein kinase I isoform X4

      Related
      ENSRNOP00000074148.1, ENSRNOT00000090096.3

    15. XM_039082078.2 → XP_038938006.1  casein kinase I isoform X7

      Conserved Domains (2) summary
      pfam12605
      Location:216 → 314
      CK1gamma_C; Casein kinase 1 gamma C terminal
      cl21453
      Location:1 → 216
      PKc_like; Protein Kinases, catalytic domain

    16. XM_039082079.2 → XP_038938007.1  casein kinase I isoform X7

      Conserved Domains (2) summary
      pfam12605
      Location:216 → 314
      CK1gamma_C; Casein kinase 1 gamma C terminal
      cl21453
      Location:1 → 216
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q62761.1 GenPept UniProtKB/Swiss-Prot:Q62761

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