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    Eef1a1 eukaryotic translation elongation factor 1 alpha 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 171361, updated on 9-Dec-2024

    Summary

    Official Symbol
    Eef1a1provided by RGD
    Official Full Name
    eukaryotic translation elongation factor 1 alpha 1provided by RGD
    Primary source
    RGD:67387
    See related
    EnsemblRapid:ENSRNOG00000009439 AllianceGenome:RGD:67387
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    SI; EF1A; EEF-1; EEF1A; Eef1a2; Eef1a2l1
    Summary
    Enables heterocyclic compound binding activity; identical protein binding activity; and mRNA binding activity. Involved in several processes, including cellular response to nerve growth factor stimulus; negative regulation of reactive oxygen species biosynthetic process; and regulation of postsynaptic specialization assembly. Is active in GABA-ergic synapse and postsynapse. Orthologous to human EEF1A1 (eukaryotic translation elongation factor 1 alpha 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 26871.9), Thymus (RPKM 23830.1) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Eef1a1 in Genome Data Viewer
    Location:
    8q31
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (88221839..88225688, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (79341554..79344784, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (85838594..85841816, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene DEAD-box helicase 43 Neighboring gene trafficking protein particle complex subunit 14 like 1 Neighboring gene cyclic GMP-AMP synthase Neighboring gene mitochondrial tRNA translation optimization 1 Neighboring gene uncharacterized LOC134480209 Neighboring gene solute carrier family 17 member 5 Neighboring gene cytochrome c, somatic-like

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Clone Names

    • MGC125172

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTP binding  
    enables GTPase activity  
    enables GTPase activity  
    enables GTPase activity  
    enables GTPase activity  
    enables calmodulin binding  
    enables heterocyclic compound binding PubMed 
    enables identical protein binding PubMed 
    enables kinase activator activity  
    enables kinase activator activity  
    enables kinase binding  
    enables mRNA binding PubMed 
    enables molecular adaptor activity  
    enables protein kinase binding  
    enables tRNA binding  
    enables translation elongation factor activity  
    enables translation elongation factor activity  
    enables translation elongation factor activity  
    enables translation elongation factor activity  
    Process Evidence Code Pubs
    involved_in cellular response to epidermal growth factor stimulus  
    involved_in cellular response to epidermal growth factor stimulus  
    involved_in cellular response to nerve growth factor stimulus PubMed 
    involved_in cellular response to xenobiotic stimulus PubMed 
    involved_in negative regulation of reactive oxygen species biosynthetic process PubMed 
    involved_in positive regulation of apoptotic process PubMed 
    involved_in positive regulation of neuron projection development PubMed 
    involved_in regulation of postsynaptic specialization assembly PubMed 
    involved_in regulation of postsynaptic specialization assembly PubMed 
    involved_in translation  
    involved_in translational elongation  
    involved_in translational elongation  
    involved_in translational elongation  
    involved_in translational elongation  
    Component Evidence Code Pubs
    is_active_in GABA-ergic synapse PubMed 
    is_active_in GABA-ergic synapse PubMed 
    located_in cortical actin cytoskeleton  
    located_in cytoplasm  
    located_in cytoplasm  
    located_in cytoplasm  
    located_in cytosol  
    located_in cytosol  
    is_active_in cytosolic ribosome  
    located_in lysosomal membrane  
    located_in nucleolus  
    located_in nucleolus  
    located_in nucleus  
    NOT located_in nucleus  
    located_in nucleus  
    located_in plasma membrane  
    located_in plasma membrane  
    is_active_in postsynapse PubMed 
    is_active_in ribosome  
    located_in ruffle membrane  

    General protein information

    Preferred Names
    elongation factor 1-alpha 1
    Names
    EF-1 alpha2
    EF-1-alpha-1
    EF-Tu
    eEF1A-1
    elongation factor 1 A-1
    elongation factor Tu
    eukaryotic elongation factor 1 A-1
    eukaryotic translation elongation factor 1 alpha 2 like 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_175838.2NP_787032.1  elongation factor 1-alpha 1

      See identical proteins and their annotated locations for NP_787032.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/Swiss-Prot
      P20001, P62630, Q5BJW8, Q64718, Q78ED4
      UniProtKB/TrEMBL
      A0A8L2Q996, A6I1K3
      Related
      ENSRNOP00000013608.4, ENSRNOT00000013608.8
      Conserved Domains (1) summary
      PTZ00141
      Location:1460
      PTZ00141; elongation factor 1- alpha; Provisional

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      88221839..88225688 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063264828.1XP_063120898.1  elongation factor 1-alpha 1 isoform X1

      UniProtKB/Swiss-Prot
      P20001, P62630, Q5BJW8, Q64718, Q78ED4
      UniProtKB/TrEMBL
      A0A8L2Q996, A6I1K3
    2. XM_063264829.1XP_063120899.1  elongation factor 1-alpha 1 isoform X1

      UniProtKB/Swiss-Prot
      P20001, P62630, Q5BJW8, Q64718, Q78ED4
      UniProtKB/TrEMBL
      A0A8L2Q996, A6I1K3
    3. XM_039080748.2XP_038936676.1  elongation factor 1-alpha 1 isoform X1

      UniProtKB/Swiss-Prot
      P20001, P62630, Q5BJW8, Q64718, Q78ED4
      UniProtKB/TrEMBL
      A0A8L2Q996, A6I1K3
      Conserved Domains (1) summary
      PTZ00141
      Location:1460
      PTZ00141; elongation factor 1- alpha; Provisional
    4. XM_039080749.2XP_038936677.1  elongation factor 1-alpha 1 isoform X1

      UniProtKB/Swiss-Prot
      P20001, P62630, Q5BJW8, Q64718, Q78ED4
      UniProtKB/TrEMBL
      A0A8L2Q996, A6I1K3
      Conserved Domains (1) summary
      PTZ00141
      Location:1460
      PTZ00141; elongation factor 1- alpha; Provisional
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