Fbxw5 F-box and WD repeat domain containing 5 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Fbxw5provided by RGD
Official Full Name: F-box and WD repeat domain containing 5provided by RGD
Primary source: RGD:1305661
See related: EnsemblRapid:ENSRNOG00000028674 AllianceGenome:RGD:1305661
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable protein kinase binding activity. Predicted to be involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; protein ubiquitination; and regulation of cell cycle process. Predicted to be located in cytoplasm. Predicted to be part of Cul4-RING E3 ubiquitin ligase complex and SCF ubiquitin ligase complex. Orthologous to human FBXW5 (F-box and WD repeat domain containing 5). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Heart (RPKM 235.2), Testes (RPKM 212.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3p13

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (28720670..28725237)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (8322543..8327092)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (2726705..2731213)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

FBXW5 acts as a negative regulator of pathological cardiac hypertrophy by decreasing the TAK1 signaling to pro-hypertrophic members of the MAPK signaling pathway.
Title: FBXW5 acts as a negative regulator of pathological cardiac hypertrophy by decreasing the TAK1 signaling to pro-hypertrophic members of the MAPK signaling pathway.
FBXW5 reduction alleviates spinal cord injury by blocking microglia activity and down-regulating p38 and JNK.
Title: FBXW5 reduction alleviates spinal cord injury (SCI) by blocking microglia activity: A mechanism involving p38 and JNK.
oxidative stress induces Tnfaip8 l1/Oxi-beta, which results in increased autophagy by its exclusive binding with FBXW5 to stabilize TSC2
Title: Tnfaip8 l1/Oxi-β binds to FBXW5, increasing autophagy through activation of TSC2 in a Parkinson's disease model.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables protein kinase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in protein ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein ubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of centrosome duplication	ISO Inferred from Sequence Orthology more info
involved_in regulation of centrosome duplication	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of mitotic nuclear division	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of Cul4-RING E3 ubiquitin ligase complex	ISO Inferred from Sequence Orthology more info
part_of Cul4-RING E3 ubiquitin ligase complex	ISS Inferred from Sequence or Structural Similarity more info
part_of SCF ubiquitin ligase complex	ISO Inferred from Sequence Orthology more info
part_of SCF ubiquitin ligase complex	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: F-box/WD repeat-containing protein 5

Names: F-box and WD-40 domain protein 5; F-box and WD-40 domain-containing protein 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001025730.2 → NP_001020901.1 F-box/WD repeat-containing protein 5

See identical proteins and their annotated locations for NP_001020901.1

Status: PROVISIONAL

Source sequence(s)

BC099179

UniProtKB/Swiss-Prot

F8WFL5, Q4KLI9

UniProtKB/TrEMBL

A6JT76

Conserved Domains (4) summary

smart00320
Location:85 → 120

WD40; WD40 repeats

sd00039
Location:475 → 501

7WD40; WD40 repeat [structural motif]

pfam12937
Location:6 → 50

F-box-like

cl29593
Location:450 → 541

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

28720670..28725237

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006233624.5 → XP_006233686.1 F-box/WD repeat-containing protein 5 isoform X1

See identical proteins and their annotated locations for XP_006233686.1

UniProtKB/Swiss-Prot

F8WFL5, Q4KLI9

UniProtKB/TrEMBL

A6JT76

Conserved Domains (4) summary

smart00320
Location:85 → 120

WD40; WD40 repeats

sd00039
Location:475 → 501

7WD40; WD40 repeat [structural motif]

pfam12937
Location:6 → 50

F-box-like

cl29593
Location:450 → 541

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_006233626.5 → XP_006233688.1 F-box/WD repeat-containing protein 5 isoform X1

See identical proteins and their annotated locations for XP_006233688.1

UniProtKB/Swiss-Prot

F8WFL5, Q4KLI9

UniProtKB/TrEMBL

A6JT76

Conserved Domains (4) summary

smart00320
Location:85 → 120

WD40; WD40 repeats

sd00039
Location:475 → 501

7WD40; WD40 repeat [structural motif]

pfam12937
Location:6 → 50

F-box-like

cl29593
Location:450 → 541

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_006233625.4 → XP_006233687.1 F-box/WD repeat-containing protein 5 isoform X1

See identical proteins and their annotated locations for XP_006233687.1

UniProtKB/Swiss-Prot

F8WFL5, Q4KLI9

UniProtKB/TrEMBL

A6JT76

Related

ENSRNOP00000029229.3, ENSRNOT00000034089.7

Conserved Domains (4) summary

smart00320
Location:85 → 120

WD40; WD40 repeats

sd00039
Location:475 → 501

7WD40; WD40 repeat [structural motif]

pfam12937
Location:6 → 50

F-box-like

cl29593
Location:450 → 541

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_006233627.4 → XP_006233689.1 F-box/WD repeat-containing protein 5 isoform X1

See identical proteins and their annotated locations for XP_006233689.1

UniProtKB/Swiss-Prot

F8WFL5, Q4KLI9

UniProtKB/TrEMBL

A6JT76

Conserved Domains (4) summary

smart00320
Location:85 → 120

WD40; WD40 repeats

sd00039
Location:475 → 501

7WD40; WD40 repeat [structural motif]

pfam12937
Location:6 → 50

F-box-like

cl29593
Location:450 → 541

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_006233628.5 → XP_006233690.1 F-box/WD repeat-containing protein 5 isoform X2

Conserved Domains (3) summary

smart00320
Location:7 → 42

WD40; WD40 repeats

sd00039
Location:397 → 423

7WD40; WD40 repeat [structural motif]

cl29593
Location:372 → 463

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_063284056.1 → XP_063140126.1 F-box/WD repeat-containing protein 5 isoform X3

UniProtKB/TrEMBL

A6JT77