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    Rassf1 Ras association domain family member 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 363140, updated on 9-Dec-2024

    Summary

    Official Symbol
    Rassf1provided by RGD
    Official Full Name
    Ras association domain family member 1provided by RGD
    Primary source
    RGD:1359383
    See related
    EnsemblRapid:ENSRNOG00000021548 AllianceGenome:RGD:1359383
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable identical protein binding activity and small GTPase binding activity. Predicted to be involved in several processes, including Ras protein signal transduction; positive regulation of protein ubiquitination; and protein stabilization. Predicted to act upstream of with a negative effect on regulation of cell cycle G1/S phase transition. Predicted to be located in microtubule. Predicted to be active in microtubule cytoskeleton and nucleus. Human ortholog(s) of this gene implicated in breast cancer; carcinoma (multiple); reproductive organ cancer (multiple); and urinary bladder cancer. Orthologous to human RASSF1 (Ras association domain family member 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 104.1), Thymus (RPKM 75.0) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Rassf1 in Genome Data Viewer
    Location:
    8q32
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (117103665..117114805)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (108225023..108236164)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (116307149..116318289)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene NPR2-like, GATOR1 complex subunit Neighboring gene zinc finger, MYND-type containing 10 Neighboring gene tumor suppressor 2, mitochondrial calcium regulator Neighboring gene hyaluronidase 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    General gene information

    Clone Names

    • MGC94319

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables identical protein binding  
    enables metal ion binding  
    enables protein binding PubMed 
    enables small GTPase binding  
    Component Evidence Code Pubs
    located_in microtubule  
    is_active_in microtubule cytoskeleton  
    located_in microtubule cytoskeleton  
    is_active_in nucleus  
    located_in nucleus  

    General protein information

    Preferred Names
    ras association domain-containing protein 1
    Names
    Ras association (RalGDS/AF-6) domain family 1
    Ras association (RalGDS/AF-6) domain family member 1
    Ras association domain family 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001007754.1NP_001007755.1  ras association domain-containing protein 1 isoform 2

      See identical proteins and their annotated locations for NP_001007755.1

      Status: PROVISIONAL

      Source sequence(s)
      BC079237
      UniProtKB/TrEMBL
      A6I2X9, F7F8L4, Q68FW0
      Related
      ENSRNOP00000034233.3, ENSRNOT00000037363.6
      Conserved Domains (2) summary
      cd17218
      Location:60216
      RA_RASSF1; Ras-associating (RA) domain found in Ras-association domain-containing protein 1 (RASSF1)
      pfam16517
      Location:226264
      Nore1-SARAH; Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain
    2. NM_001037555.2NP_001032644.1  ras association domain-containing protein 1 isoform 1

      See identical proteins and their annotated locations for NP_001032644.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A0A9K3Y7P1, F1M9A9, Q5FAQ9
      Related
      ENSRNOP00000030024.4, ENSRNOT00000037375.8
      Conserved Domains (3) summary
      cd17218
      Location:130286
      RA_RASSF1; Ras-associating (RA) domain found in Ras-association domain-containing protein 1 (RASSF1)
      pfam16517
      Location:296334
      Nore1-SARAH; Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain
      cd20885
      Location:49102
      C1_RASSF1; protein kinase C conserved region 1 (C1 domain) found in Ras association domain-containing protein 1 (RASSF1) and similar proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      117103665..117114805
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039081797.2XP_038937725.1  ras association domain-containing protein 1 isoform X1

      Conserved Domains (2) summary
      cd17218
      Location:27183
      RA_RASSF1; Ras-associating (RA) domain found in Ras-association domain-containing protein 1 (RASSF1)
      pfam16517
      Location:193231
      Nore1-SARAH; Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain
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