Icos inducible T-cell co-stimulator [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Icosprovided by RGD
Official Full Name: inducible T-cell co-stimulatorprovided by RGD
Primary source: RGD:620123
See related: EnsemblRapid:ENSRNOG00000046196 AllianceGenome:RGD:620123
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ailim
Summary: Involved in T cell costimulation; T cell tolerance induction; and cell-cell adhesion. Predicted to be located in external side of plasma membrane. Used to study myocarditis. Biomarker of colitis and uveitis. Human ortholog(s) of this gene implicated in celiac disease; common variable immunodeficiency 1; and immunoglobulin alpha deficiency. Orthologous to human ICOS (inducible T cell costimulator). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 162.0), Spleen (RPKM 50.6) and 2 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 9q32

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	9	NC_086027.1 (69862042..69900864)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	9	NC_051344.1 (62368075..62406900)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	9	NC_005108.4 (67748157..67786808)

Chromosome 9 - NC_086027.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

the increased expression of ICOS/ICOS ligand in periapical lesions was associated with the inflammatory infiltration and alveolar bone destruction of apical periodontitis
Title: Association between Increased Inducible Costimulator/Inducible Costimulator Ligand Expression with Bone Destruction in Apical Periodontitis.
ICOS-targeted siRNA can effectively silence gene expression of ICOS, and provided satisfactory treatment efficacy for myocardial cell hypertrophy after infarction.
Title: Effect of siRNA silencing of inducible co-stimulatory molecule on myocardial cell hypertrophy after cardiac infarction in rats.
ICOS siRNA can protect brain tissues from ischemia injuries after cerebral infarction, improve limb movement and coordination, lower the mortality rate of rats, and inhibit T cell-induced cytokines
Title: Effect of Inducible Co-Stimulatory Molecule siRNA in Cerebral Infarction Rat Models.
our data highlight a key role for ICOS signaling in the generation of imbalanced production of IL-10 and IL-17 by Treg cells in a rat model of spondyloarthritis.
Title: Increased production of interleukin-17 over interleukin-10 by treg cells implicates inducible costimulator molecule in experimental spondyloarthritis.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables signaling receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in T cell costimulation	IBA Inferred from Biological aspect of Ancestor more info
involved_in T cell costimulation	IDA Inferred from Direct Assay more info	PubMed
involved_in T cell costimulation	IEA Inferred from Electronic Annotation more info
involved_in T cell tolerance induction	IBA Inferred from Biological aspect of Ancestor more info
involved_in T cell tolerance induction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in T follicular helper cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-cell adhesion	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: inducible T-cell costimulator

Names: activation-inducible lymphocyte immunomediatory molecule

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001431817.1 → NP_001418746.1 inducible T-cell costimulator isoform 2 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000009
NM_001431818.1 → NP_001418747.1 inducible T-cell costimulator isoform 1 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000009

UniProtKB/Swiss-Prot

Q9R1T7, Q9WVR9

UniProtKB/TrEMBL

A0A0G2JZC0, A6IPD8
NM_001431819.1 → NP_001418748.1 inducible T-cell costimulator isoform 2 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000009
NM_022610.3 → NP_072132.1 inducible T-cell costimulator isoform 1 precursor

See identical proteins and their annotated locations for NP_072132.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000009

UniProtKB/Swiss-Prot

Q9R1T7, Q9WVR9

UniProtKB/TrEMBL

A0A0G2JZC0, A6IPD8

Related

ENSRNOP00000064455.1, ENSRNOT00000071226.4

Conserved Domains (1) summary

pfam15910
Location:23 → 135

V-set_2; ICOS V-set domain