Cadm3 cell adhesion molecule 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cadm3provided by RGD
Official Full Name: cell adhesion molecule 3provided by RGD
Primary source: RGD:1307035
See related: EnsemblRapid:ENSRNOG00000003365 AllianceGenome:RGD:1307035
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Igsf4b; Necl-1
Summary: Predicted to enable protein homodimerization activity. Involved in synaptic membrane adhesion. Is active in GABA-ergic synapse and glutamatergic synapse. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease. Orthologous to human CADM3 (cell adhesion molecule 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 513.9), Heart (RPKM 92.3) and 5 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 13q24

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (88317124..88349718, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (85784785..85817412, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (91842311..91873126, complement)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Necl1 plays an important role in neuronal synapse formation.
Title: [Role of cell adhesion molecules Necl1 in synaptogenesis in primary cultured rat neurons].
These results demonstrate a key role for Necl, 2 and 4 in initiating peripheral nervous system myelination and implicate the Necl proteins as mediators of axo-glial interactions along the internode.
Title: Nectin-like proteins mediate axon Schwann cell interactions along the internode and are essential for myelination.
Nectin-like molecule 1 (Necl-1) is unique for its exclusive expression in the brain where it is localized at the contact sites among axon terminals and glia cell processes, cooperatively forming synapses.
Title: Nectin-like molecule 1 is a high abundance protein in cerebellar neurons.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	ISO Inferred from Sequence Orthology more info
involved_in homophilic cell adhesion via plasma membrane adhesion molecules	IBA Inferred from Biological aspect of Ancestor more info
involved_in homophilic cell adhesion via plasma membrane adhesion molecules	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein localization	ISO Inferred from Sequence Orthology more info
involved_in synaptic membrane adhesion	IDA Inferred from Direct Assay more info	PubMed
involved_in synaptic membrane adhesion	IEP Inferred from Expression Pattern more info	PubMed
involved_in synaptic membrane adhesion	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in GABA-ergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in GABA-ergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in cell-cell junction	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in parallel fiber to Purkinje cell synapse	ISO Inferred from Sequence Orthology more info
is_active_in presynaptic membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in presynaptic membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: cell adhesion molecule 3

Names: immunoglobulin superfamily, member 4B; nectin-like protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001047103.2 → NP_001040568.1 cell adhesion molecule 3 isoform 2 precursor

See identical proteins and their annotated locations for NP_001040568.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000013

UniProtKB/Swiss-Prot

Q1WIM3

UniProtKB/TrEMBL

A0A8L2UHK9

Related

ENSRNOP00000004613.5, ENSRNOT00000004613.8

Conserved Domains (5) summary

smart00294
Location:352 → 367

4.1m; putative band 4.1 homologues' binding motif

cd05882
Location:30 → 124

Ig1_Necl-1; First (N-terminal) immunoglobulin (Ig)-like domain of nectin-like molcule-1 (Necl-1, also known as cell adhesion molecule3 (CADM3))

smart00410
Location:237 → 314

IG_like; Immunoglobulin like

pfam13895
Location:235 → 314

Ig_2; Immunoglobulin domain

cl11960
Location:145 → 227

Ig; Immunoglobulin domain
NM_001412817.1 → NP_001399746.1 cell adhesion molecule 3 isoform 1 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000013

UniProtKB/TrEMBL

A0A8I6ACH5

Related

ENSRNOP00000091652.1, ENSRNOT00000099664.2