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    EEF1D eukaryotic translation elongation factor 1 delta [ Homo sapiens (human) ]

    Gene ID: 1936, updated on 4-Jan-2025

    Summary

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    Official Symbol
    EEF1Dprovided by HGNC
    Official Full Name
    eukaryotic translation elongation factor 1 deltaprovided by HGNC
    Primary source
    HGNC:HGNC:3211
    See related
    Ensembl:ENSG00000104529 MIM:130592; AllianceGenome:HGNC:3211
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    EF1D; EF-1D; FP1047
    Summary
    This gene encodes a subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This subunit, delta, functions as guanine nucleotide exchange factor. It is reported that following HIV-1 infection, this subunit interacts with HIV-1 Tat. This interaction results in repression of translation of host cell proteins and enhanced translation of viral proteins. Several alternatively spliced transcript variants encoding multiple isoforms have been found for this gene. Related pseudogenes have been defined on chromosomes 1, 6, 7, 9, 11, 13, 17, 19.[provided by RefSeq, Aug 2010]
    Expression
    Ubiquitous expression in ovary (RPKM 42.9), spleen (RPKM 28.8) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See EEF1D in Genome Data Viewer
    Location:
    8q24.3
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (143579728..143597415, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (144729124..144746827, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (144661898..144679585, complement)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene maestro heat like repeat family member 6 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:144653451-144654300 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:144659908-144660815 Neighboring gene nicotinate phosphoribosyltransferase Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:144660816-144661724 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:144671257-144671758 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:144671759-144672258 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:144678233-144678832 Neighboring gene tigger transposable element derived 5 Neighboring gene pyrroline-5-carboxylate reductase 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:144692853-144693352 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:144699896-144700500 Neighboring gene GDP-L-fucose synthase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. Clinical significance of elongation factor-1 delta mRNA expression in oesophageal carcinoma. Ogawa K, et al. Br J Cancer, 2004 Jul 19. PMID 15199388, Free PMC Article
    2. Biallelic loss of EEF1D function links heat shock response pathway to autosomal recessive intellectual disability. Ugur Iseri SA, et al. J Hum Genet, 2019 May. PMID 30787422
    3. Autoantibodies against eukaryotic translation elongation factor 1 delta in two patients with autoimmune cerebellar ataxia. Guo L, et al. Front Immunol, 2023. PMID 38332912, Free PMC Article
    4. Induction of acute translational response genes by homocysteine. Elongation factors-1alpha, -beta, and -delta. Chacko G, et al. J Biol Chem, 1998 Jul 31. PMID 9677419
    5. BMP-6 promotes E-cadherin expression through repressing deltaEF1 in breast cancer cells. Yang S, et al. BMC Cancer, 2007 Nov 13. PMID 17997862, Free PMC Article

    See all (252) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. EEF1D stabilized by SRSF9 promotes colorectal cancer via enhancing the proliferation and metastasis.
      Title: EEF1D stabilized by SRSF9 promotes colorectal cancer via enhancing the proliferation and metastasis.
    2. Autoantibodies against eukaryotic translation elongation factor 1 delta in two patients with autoimmune cerebellar ataxia.
      Title: Autoantibodies against eukaryotic translation elongation factor 1 delta in two patients with autoimmune cerebellar ataxia.
    3. EEF1D Promotes Glioma Proliferation, Migration, and Invasion through EMT and PI3K/Akt Pathway.
      Title: EEF1D Promotes Glioma Proliferation, Migration, and Invasion through EMT and PI3K/Akt Pathway.
    4. Eukaryotic Translation Elongation Factor 1 Delta Inhibits the Nuclear Import of the Nucleoprotein and PA-PB1 Heterodimer of Influenza A Virus.
      Title: Eukaryotic Translation Elongation Factor 1 Delta Inhibits the Nuclear Import of the Nucleoprotein and PA-PB1 Heterodimer of Influenza A Virus.
    5. EEF1D is upregulated in osteosarcoma and plays a tumor promoting role by facilitating Akt-mTOR and Akt-Bad signaling pathways. Accordingly, EEF1D is a potential target for cancer therapy.
      Title: EEF1D overexpression promotes osteosarcoma cell proliferation by facilitating Akt-mTOR and Akt-bad signaling.
    6. the loss of function variants exclusively targeting the long EEF1D isoform may explicate the ARID phenotype through the heat shock response pathway, rather than interfering with the canonical translational elongation.
      Title: Biallelic loss of EEF1D function links heat shock response pathway to autosomal recessive intellectual disability.
    7. eukaryotic translation elongation factor 1delta knockdown in oral squamous cell carcinoma reduced cell proliferation and induced EMT (epithelial-mesenchymal transition) phenotypes
      Title: EEF1D modulates proliferation and epithelial-mesenchymal transition in oral squamous cell carcinoma.
    8. our results demonstrate that EEF1D is a bona fide physiological CK2 substrate for CK2 phosphorylation
      Title: Unbiased functional proteomics strategy for protein kinase inhibitor validation and identification of bona fide protein kinase substrates: application to identification of EEF1D as a substrate for CK2.
    9. Taken together, our data suggest EFF1D functions as a novel negative regulator of SIAH-1
      Title: Eukaryotic translation elongation factor 1 delta inhibits the ubiquitin ligase activity of SIAH-1.
    10. overexpression is positively correlated with malignant transformation of 16HBE cells induced by CdC12, but is not correlated with DNA mutations
      Title: Alternative expression and sequence of human elongation factor-1 delta during malignant transformation of human bronchial epithelial cells induced by cadmium chloride.
    Submit: New GeneRIF Correction See all GeneRIFs (15)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify eukaryotic translation elongation factor 1 delta (EEF1D), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify eukaryotic translation elongation factor 1 delta (EEF1D), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Nef nef Tandem affinity purification and mass spectrometry analysis identify eukaryotic translation elongation factor 1 delta (EEF1D), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    nef Yeast two hybrid assay identifies the HIV-1 Nef-interacting protein translational elongation factor 1 PubMed
    Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify eukaryotic translation elongation factor 1 delta (EEF1D), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Tat tat The second exon of HIV-1 Tat (amino acids 73-86) binds to EF-1delta (amino acids 144-280), thereby dramatically reducing the efficiency of the translation of cellular, but not viral, mRNA PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ20897

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cadherin binding HDA PubMed 
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables heat shock protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables translation elongation factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables translation factor activity, RNA binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to heat IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular response to ionizing radiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cytoplasmic translational elongation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in translational elongation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    colocalizes_with endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of eukaryotic translation elongation factor 1 complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in fibrillar center IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleus HDA PubMed 
    NOT located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    elongation factor 1-delta
    Names
    EF-1-delta
    antigen NY-CO-4
    eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001130053.5 → NP_001123525.3  elongation factor 1-delta isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1 and 3 both encode the same isoform (1, also known as L).
      Source sequence(s)
      AC067930
      Consensus CDS
      CCDS6404.1
      UniProtKB/TrEMBL
      B2RAR6
      Related
      ENSP00000484536.2, ENST00000618139.4
      Conserved Domains (2) summary
      pfam10587
      Location:525 → 552
      EF-1_beta_acid; Eukaryotic elongation factor 1 beta central acidic region
      pfam00736
      Location:564 → 647
      EF1_GNE; EF-1 guanine nucleotide exchange domain

    2. NM_001130055.4 → NP_001123527.1  elongation factor 1-delta isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1. Variants 2, 5, 6, and 9 encode the same isoform (2).
      Source sequence(s)
      AK225040, BI667117, BQ686171, DA948687
      Consensus CDS
      CCDS6405.1
      UniProtKB/Swiss-Prot
      B4DDU4, D3DWK3, E9PBQ9, P29692, Q4VBZ6, Q969J1, Q96I38
      UniProtKB/TrEMBL
      E9PK01
      Related
      ENSP00000388261.2, ENST00000419152.7
      Conserved Domains (2) summary
      pfam00736
      Location:198 → 281
      EF1_GNE; EF-1 guanine nucleotide exchange domain
      pfam10587
      Location:159 → 186
      EF-1_beta_acid; Eukaryotic elongation factor 1 beta central acidic region

    3. NM_001130056.5 → NP_001123528.1  elongation factor 1-delta isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) has multiple differences compared to variant 1. The encoded isoform (4) is shorter than isoform 1. Both variants 7, 10, and 11 encode the same isoform (4).
      Source sequence(s)
      AK225040, BC094806, BI667117
      Consensus CDS
      CCDS47930.1
      UniProtKB/TrEMBL
      E9PQZ1
      Related
      ENSP00000431763.1, ENST00000528610.5
      Conserved Domains (2) summary
      pfam00736
      Location:174 → 257
      EF1_GNE; EF-1 guanine nucleotide exchange domain
      pfam10587
      Location:135 → 162
      EF-1_beta_acid; Eukaryotic elongation factor 1 beta central acidic region

    4. NM_001130057.4 → NP_001123529.1  elongation factor 1-delta isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1. Variants 2, 5, 6, and 9 encode the same isoform (2).
      Source sequence(s)
      AC067930, AK225040, BG748894, BQ064320, CF128478
      Consensus CDS
      CCDS6405.1
      UniProtKB/Swiss-Prot
      B4DDU4, D3DWK3, E9PBQ9, P29692, Q4VBZ6, Q969J1, Q96I38
      UniProtKB/TrEMBL
      E9PK01
      Related
      ENSP00000317399.6, ENST00000317198.10
      Conserved Domains (2) summary
      pfam00736
      Location:198 → 281
      EF1_GNE; EF-1 guanine nucleotide exchange domain
      pfam10587
      Location:159 → 186
      EF-1_beta_acid; Eukaryotic elongation factor 1 beta central acidic region

    5. NM_001195203.4 → NP_001182132.1  elongation factor 1-delta isoform 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. This variant also lacks an additional in-frame exon and uses an alternate in-frame splice site in the CDS. The encoded isoform (5) is shorter than isoform 1.
      Source sequence(s)
      AK225040, AK293339, BI667117
      Consensus CDS
      CCDS56559.1
      UniProtKB/TrEMBL
      E9PQZ1
      Related
      ENSP00000436507.1, ENST00000526838.5
      Conserved Domains (2) summary
      pfam00736
      Location:179 → 262
      EF1_GNE; EF-1 guanine nucleotide exchange domain
      pfam10587
      Location:140 → 167
      EF-1_beta_acid; Eukaryotic elongation factor 1 beta central acidic region

    6. NM_001289950.4 → NP_001276879.1  elongation factor 1-delta isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9) differs in the 5' UTR, lacks a portion of the 5' coding region, and intiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1. Variants 2, 5, 6, and 9 encode the same isoform (2).
      Source sequence(s)
      AC067930
      Consensus CDS
      CCDS6405.1
      UniProtKB/Swiss-Prot
      B4DDU4, D3DWK3, E9PBQ9, P29692, Q4VBZ6, Q969J1, Q96I38
      UniProtKB/TrEMBL
      E9PK01
      Related
      ENSP00000434872.1, ENST00000529272.5
      Conserved Domains (2) summary
      pfam00736
      Location:198 → 281
      EF1_GNE; EF-1 guanine nucleotide exchange domain
      pfam10587
      Location:159 → 186
      EF-1_beta_acid; Eukaryotic elongation factor 1 beta central acidic region

    7. NM_001317743.4 → NP_001304672.1  elongation factor 1-delta isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10) has multiple differences compared to variant 1. The encoded isoform (4) is shorter than isoform 1. Both variants 7, 10, and 11 encode the same isoform (4).
      Source sequence(s)
      AK225040, BG482145, BI667117
      Consensus CDS
      CCDS47930.1
      UniProtKB/TrEMBL
      E9PQZ1
      Related
      ENSP00000431460.2, ENST00000534377.6
      Conserved Domains (2) summary
      pfam00736
      Location:174 → 257
      EF1_GNE; EF-1 guanine nucleotide exchange domain
      pfam10587
      Location:135 → 162
      EF-1_beta_acid; Eukaryotic elongation factor 1 beta central acidic region

    8. NM_001330646.3 → NP_001317575.1  elongation factor 1-delta isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC067930
      Consensus CDS
      CCDS47930.1
      UniProtKB/TrEMBL
      E9PQZ1

    9. NM_001960.7 → NP_001951.2  elongation factor 1-delta isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1. Variants 2, 5, 6, and 9 encode the same isoform (2).
      Source sequence(s)
      AK225040, BC012819, BI667117
      Consensus CDS
      CCDS6405.1
      UniProtKB/Swiss-Prot
      B4DDU4, D3DWK3, E9PBQ9, P29692, Q4VBZ6, Q969J1, Q96I38
      UniProtKB/TrEMBL
      E9PK01
      Related
      ENSP00000378551.3, ENST00000395119.7
      Conserved Domains (2) summary
      pfam00736
      Location:198 → 281
      EF1_GNE; EF-1 guanine nucleotide exchange domain
      pfam10587
      Location:159 → 186
      EF-1_beta_acid; Eukaryotic elongation factor 1 beta central acidic region

    10. NM_032378.7 → NP_115754.4  elongation factor 1-delta isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Variants 1 and 3 both encode the same isoform (1, also known as L).
      Source sequence(s)
      AC067930
      Consensus CDS
      CCDS6404.1
      UniProtKB/TrEMBL
      B2RAR6
      Related
      ENSP00000391944.2, ENST00000442189.6
      Conserved Domains (2) summary
      pfam10587
      Location:525 → 552
      EF-1_beta_acid; Eukaryotic elongation factor 1 beta central acidic region
      pfam00736
      Location:564 → 647
      EF1_GNE; EF-1 guanine nucleotide exchange domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      143579728..143597415 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047421455.1 → XP_047277411.1  elongation factor 1-delta isoform X10

      UniProtKB/TrEMBL
      B2RAR6

    2. XM_017013171.1 → XP_016868660.1  elongation factor 1-delta isoform X7

      UniProtKB/TrEMBL
      B2RAR6
      Conserved Domains (2) summary
      pfam00736
      Location:563 → 646
      EF1_GNE; EF-1 guanine nucleotide exchange domain
      pfam10587
      Location:524 → 551
      EF-1_beta_acid; Eukaryotic elongation factor 1 beta central acidic region

    3. XM_047421450.1 → XP_047277406.1  elongation factor 1-delta isoform X9

      UniProtKB/TrEMBL
      B2RAR6

    4. XM_005250823.1 → XP_005250880.1  elongation factor 1-delta isoform X6

      UniProtKB/TrEMBL
      B2RAR6
      Related
      ENSP00000434070.1, ENST00000532741.5
      Conserved Domains (2) summary
      pfam10587
      Location:525 → 552
      EF-1_beta_acid; Eukaryotic elongation factor 1 beta central acidic region
      pfam00736
      Location:564 → 647
      EF1_GNE; EF-1 guanine nucleotide exchange domain

    5. XM_047421441.1 → XP_047277397.1  elongation factor 1-delta isoform X6

      UniProtKB/TrEMBL
      B2RAR6

    6. XM_047421423.1 → XP_047277379.1  elongation factor 1-delta isoform X1

      UniProtKB/TrEMBL
      B2RAR6

    7. XM_006716525.2 → XP_006716588.1  elongation factor 1-delta isoform X11

      UniProtKB/Swiss-Prot
      B4DDU4, D3DWK3, E9PBQ9, P29692, Q4VBZ6, Q969J1, Q96I38
      UniProtKB/TrEMBL
      E9PK01
      Conserved Domains (2) summary
      pfam00736
      Location:198 → 281
      EF1_GNE; EF-1 guanine nucleotide exchange domain
      pfam10587
      Location:159 → 186
      EF-1_beta_acid; Eukaryotic elongation factor 1 beta central acidic region

    8. XM_047421445.1 → XP_047277401.1  elongation factor 1-delta isoform X7

      UniProtKB/TrEMBL
      B2RAR6

    9. XM_047421451.1 → XP_047277407.1  elongation factor 1-delta isoform X9

      UniProtKB/TrEMBL
      B2RAR6

    10. XM_047421433.1 → XP_047277389.1  elongation factor 1-delta isoform X6

      UniProtKB/TrEMBL
      B2RAR6

    11. XM_047421442.1 → XP_047277398.1  elongation factor 1-delta isoform X6

      UniProtKB/TrEMBL
      B2RAR6

    12. XM_047421422.1 → XP_047277378.1  elongation factor 1-delta isoform X1

      UniProtKB/TrEMBL
      B2RAR6

    13. XM_047421421.1 → XP_047277377.1  elongation factor 1-delta isoform X1

      UniProtKB/TrEMBL
      B2RAR6

    14. XM_047421432.1 → XP_047277388.1  elongation factor 1-delta isoform X6

      UniProtKB/TrEMBL
      B2RAR6

    15. XM_047421430.1 → XP_047277386.1  elongation factor 1-delta isoform X6

      UniProtKB/TrEMBL
      B2RAR6

    16. XM_047421427.1 → XP_047277383.1  elongation factor 1-delta isoform X6

      UniProtKB/TrEMBL
      B2RAR6

    17. XM_047421424.1 → XP_047277380.1  elongation factor 1-delta isoform X4

      UniProtKB/TrEMBL
      B2RAR6

    18. XM_006716519.5 → XP_006716582.3  elongation factor 1-delta isoform X2

      UniProtKB/TrEMBL
      B2RAR6

    19. XM_006716520.5 → XP_006716583.3  elongation factor 1-delta isoform X3

      UniProtKB/TrEMBL
      B2RAR6

    20. XM_047421420.1 → XP_047277376.1  elongation factor 1-delta isoform X1

      UniProtKB/TrEMBL
      B2RAR6

    21. XM_047421454.1 → XP_047277410.1  elongation factor 1-delta isoform X10

      UniProtKB/TrEMBL
      B2RAR6

    22. XM_047421443.1 → XP_047277399.1  elongation factor 1-delta isoform X7

      UniProtKB/TrEMBL
      B2RAR6

    23. XM_047421447.1 → XP_047277403.1  elongation factor 1-delta isoform X9

      UniProtKB/TrEMBL
      B2RAR6

    24. XM_047421426.1 → XP_047277382.1  elongation factor 1-delta isoform X6

      UniProtKB/TrEMBL
      B2RAR6

    25. XM_047421446.1 → XP_047277402.1  elongation factor 1-delta isoform X8

      UniProtKB/TrEMBL
      B2RAR6

    26. XM_047421425.1 → XP_047277381.1  elongation factor 1-delta isoform X5

      UniProtKB/TrEMBL
      B2RAR6

    27. XM_047421440.1 → XP_047277396.1  elongation factor 1-delta isoform X6

      UniProtKB/TrEMBL
      B2RAR6

    28. XM_047421438.1 → XP_047277394.1  elongation factor 1-delta isoform X6

      UniProtKB/TrEMBL
      B2RAR6

    29. XM_047421437.1 → XP_047277393.1  elongation factor 1-delta isoform X6

      UniProtKB/TrEMBL
      B2RAR6

    30. XM_047421436.1 → XP_047277392.1  elongation factor 1-delta isoform X6

      UniProtKB/TrEMBL
      B2RAR6

    31. XM_024447088.2 → XP_024302856.1  elongation factor 1-delta isoform X7

      UniProtKB/TrEMBL
      B2RAR6
      Conserved Domains (2) summary
      pfam00736
      Location:563 → 646
      EF1_GNE; EF-1 guanine nucleotide exchange domain
      pfam10587
      Location:524 → 551
      EF-1_beta_acid; Eukaryotic elongation factor 1 beta central acidic region

    32. XM_047421453.1 → XP_047277409.1  elongation factor 1-delta isoform X9

      UniProtKB/TrEMBL
      B2RAR6

    33. XM_047421439.1 → XP_047277395.1  elongation factor 1-delta isoform X6

      UniProtKB/TrEMBL
      B2RAR6

    34. XM_047421431.1 → XP_047277387.1  elongation factor 1-delta isoform X6

      UniProtKB/TrEMBL
      B2RAR6

    35. XM_047421449.1 → XP_047277405.1  elongation factor 1-delta isoform X9

      UniProtKB/TrEMBL
      B2RAR6

    36. XM_006716522.2 → XP_006716585.1  elongation factor 1-delta isoform X6

      UniProtKB/TrEMBL
      B2RAR6
      Conserved Domains (2) summary
      pfam10587
      Location:525 → 552
      EF-1_beta_acid; Eukaryotic elongation factor 1 beta central acidic region
      pfam00736
      Location:564 → 647
      EF1_GNE; EF-1 guanine nucleotide exchange domain

    37. XM_047421435.1 → XP_047277391.1  elongation factor 1-delta isoform X6

      UniProtKB/TrEMBL
      B2RAR6

    38. XM_006716524.2 → XP_006716587.1  elongation factor 1-delta isoform X6

      UniProtKB/TrEMBL
      B2RAR6
      Conserved Domains (2) summary
      pfam10587
      Location:525 → 552
      EF-1_beta_acid; Eukaryotic elongation factor 1 beta central acidic region
      pfam00736
      Location:564 → 647
      EF1_GNE; EF-1 guanine nucleotide exchange domain

    39. XM_047421434.1 → XP_047277390.1  elongation factor 1-delta isoform X6

      UniProtKB/TrEMBL
      B2RAR6

    40. XM_047421444.1 → XP_047277400.1  elongation factor 1-delta isoform X7

      UniProtKB/TrEMBL
      B2RAR6

    41. XM_047421448.1 → XP_047277404.1  elongation factor 1-delta isoform X9

      UniProtKB/TrEMBL
      B2RAR6

    42. XM_047421429.1 → XP_047277385.1  elongation factor 1-delta isoform X6

      UniProtKB/TrEMBL
      B2RAR6

    43. XM_047421452.1 → XP_047277408.1  elongation factor 1-delta isoform X9

      UniProtKB/TrEMBL
      B2RAR6

    44. XM_047421428.1 → XP_047277384.1  elongation factor 1-delta isoform X6

      UniProtKB/TrEMBL
      B2RAR6

    Reference GRCh38.p14 ALT_REF_LOCI_1

    Genomic

    1. NT_187571.1 Reference GRCh38.p14 ALT_REF_LOCI_1

      Range
      69768..87455 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054328747.1 → XP_054184722.1  elongation factor 1-delta isoform X10

      UniProtKB/TrEMBL
      B2RAR6

    2. XM_054328738.1 → XP_054184713.1  elongation factor 1-delta isoform X7

      UniProtKB/TrEMBL
      B2RAR6

    3. XM_054328743.1 → XP_054184718.1  elongation factor 1-delta isoform X9

      UniProtKB/TrEMBL
      B2RAR6

    4. XM_054328727.1 → XP_054184702.1  elongation factor 1-delta isoform X6

      UniProtKB/TrEMBL
      B2RAR6

    5. XM_054328734.1 → XP_054184709.1  elongation factor 1-delta isoform X6

      UniProtKB/TrEMBL
      B2RAR6

    6. XM_054328717.1 → XP_054184692.1  elongation factor 1-delta isoform X1

      UniProtKB/TrEMBL
      B2RAR6

    7. XM_054328748.1 → XP_054184723.1  elongation factor 1-delta isoform X11

      UniProtKB/Swiss-Prot
      B4DDU4, D3DWK3, E9PBQ9, P29692, Q4VBZ6, Q969J1, Q96I38
      UniProtKB/TrEMBL
      E9PK01

    8. XM_054328739.1 → XP_054184714.1  elongation factor 1-delta isoform X7

      UniProtKB/TrEMBL
      B2RAR6

    9. XM_054328744.1 → XP_054184719.1  elongation factor 1-delta isoform X9

      UniProtKB/TrEMBL
      B2RAR6

    10. XM_054328730.1 → XP_054184705.1  elongation factor 1-delta isoform X6

      UniProtKB/TrEMBL
      B2RAR6

    11. XM_054328735.1 → XP_054184710.1  elongation factor 1-delta isoform X6

      UniProtKB/TrEMBL
      B2RAR6

    12. XM_054328716.1 → XP_054184691.1  elongation factor 1-delta isoform X1

      UniProtKB/TrEMBL
      B2RAR6

    13. XM_054328715.1 → XP_054184690.1  elongation factor 1-delta isoform X1

      UniProtKB/TrEMBL
      B2RAR6

    14. XM_054328723.1 → XP_054184698.1  elongation factor 1-delta isoform X6

      UniProtKB/TrEMBL
      B2RAR6

    15. XM_054328729.1 → XP_054184704.1  elongation factor 1-delta isoform X6

      UniProtKB/TrEMBL
      B2RAR6

    16. XM_054328728.1 → XP_054184703.1  elongation factor 1-delta isoform X6

      UniProtKB/TrEMBL
      B2RAR6

    17. XM_054328720.1 → XP_054184695.1  elongation factor 1-delta isoform X4

      UniProtKB/TrEMBL
      B2RAR6

    18. XM_054328718.1 → XP_054184693.1  elongation factor 1-delta isoform X2

      UniProtKB/TrEMBL
      B2RAR6

    19. XM_054328719.1 → XP_054184694.1  elongation factor 1-delta isoform X3

      UniProtKB/TrEMBL
      B2RAR6

    20. XM_054328714.1 → XP_054184689.1  elongation factor 1-delta isoform X1

      UniProtKB/TrEMBL
      B2RAR6

    21. XM_054328746.1 → XP_054184721.1  elongation factor 1-delta isoform X10

      UniProtKB/TrEMBL
      B2RAR6

    22. XM_054328736.1 → XP_054184711.1  elongation factor 1-delta isoform X7

      UniProtKB/TrEMBL
      B2RAR6

    23. XM_054328741.1 → XP_054184716.1  elongation factor 1-delta isoform X9

      UniProtKB/TrEMBL
      B2RAR6

    24. XM_054328722.1 → XP_054184697.1  elongation factor 1-delta isoform X6

      UniProtKB/TrEMBL
      B2RAR6

    25. XM_054328740.1 → XP_054184715.1  elongation factor 1-delta isoform X8

      UniProtKB/TrEMBL
      B2RAR6

    26. XM_054328721.1 → XP_054184696.1  elongation factor 1-delta isoform X5

      UniProtKB/TrEMBL
      B2RAR6

    27. XM_054328726.1 → XP_054184701.1  elongation factor 1-delta isoform X6

      UniProtKB/TrEMBL
      B2RAR6

    28. XM_054328733.1 → XP_054184708.1  elongation factor 1-delta isoform X6

      UniProtKB/TrEMBL
      B2RAR6

    29. XM_054328732.1 → XP_054184707.1  elongation factor 1-delta isoform X6

      UniProtKB/TrEMBL
      B2RAR6

    30. XM_054328731.1 → XP_054184706.1  elongation factor 1-delta isoform X6

      UniProtKB/TrEMBL
      B2RAR6

    31. XM_054328737.1 → XP_054184712.1  elongation factor 1-delta isoform X7

      UniProtKB/TrEMBL
      B2RAR6

    32. XM_054328742.1 → XP_054184717.1  elongation factor 1-delta isoform X9

      UniProtKB/TrEMBL
      B2RAR6

    33. XM_054328725.1 → XP_054184700.1  elongation factor 1-delta isoform X6

      UniProtKB/TrEMBL
      B2RAR6

    34. XM_054328745.1 → XP_054184720.1  elongation factor 1-delta isoform X9

      UniProtKB/TrEMBL
      B2RAR6

    35. XM_054328724.1 → XP_054184699.1  elongation factor 1-delta isoform X6

      UniProtKB/TrEMBL
      B2RAR6

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      144729124..144746827 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054359944.1 → XP_054215919.1  elongation factor 1-delta isoform X10

      UniProtKB/TrEMBL
      B2RAR6

    2. XM_054359935.1 → XP_054215910.1  elongation factor 1-delta isoform X7

      UniProtKB/TrEMBL
      B2RAR6

    3. XM_054359940.1 → XP_054215915.1  elongation factor 1-delta isoform X9

      UniProtKB/TrEMBL
      B2RAR6

    4. XM_054359924.1 → XP_054215899.1  elongation factor 1-delta isoform X6

      UniProtKB/TrEMBL
      B2RAR6

    5. XM_054359931.1 → XP_054215906.1  elongation factor 1-delta isoform X6

      UniProtKB/TrEMBL
      B2RAR6

    6. XM_054359914.1 → XP_054215889.1  elongation factor 1-delta isoform X1

      UniProtKB/TrEMBL
      B2RAR6

    7. XM_054359945.1 → XP_054215920.1  elongation factor 1-delta isoform X11

      UniProtKB/Swiss-Prot
      B4DDU4, D3DWK3, E9PBQ9, P29692, Q4VBZ6, Q969J1, Q96I38
      UniProtKB/TrEMBL
      E9PK01

    8. XM_054359936.1 → XP_054215911.1  elongation factor 1-delta isoform X7

      UniProtKB/TrEMBL
      B2RAR6

    9. XM_054359941.1 → XP_054215916.1  elongation factor 1-delta isoform X9

      UniProtKB/TrEMBL
      B2RAR6

    10. XM_054359927.1 → XP_054215902.1  elongation factor 1-delta isoform X6

      UniProtKB/TrEMBL
      B2RAR6

    11. XM_054359932.1 → XP_054215907.1  elongation factor 1-delta isoform X6

      UniProtKB/TrEMBL
      B2RAR6

    12. XM_054359913.1 → XP_054215888.1  elongation factor 1-delta isoform X1

      UniProtKB/TrEMBL
      B2RAR6

    13. XM_054359912.1 → XP_054215887.1  elongation factor 1-delta isoform X1

      UniProtKB/TrEMBL
      B2RAR6

    14. XM_054359920.1 → XP_054215895.1  elongation factor 1-delta isoform X6

      UniProtKB/TrEMBL
      B2RAR6

    15. XM_054359926.1 → XP_054215901.1  elongation factor 1-delta isoform X6

      UniProtKB/TrEMBL
      B2RAR6

    16. XM_054359925.1 → XP_054215900.1  elongation factor 1-delta isoform X6

      UniProtKB/TrEMBL
      B2RAR6

    17. XM_054359917.1 → XP_054215892.1  elongation factor 1-delta isoform X4

      UniProtKB/TrEMBL
      B2RAR6

    18. XM_054359915.1 → XP_054215890.1  elongation factor 1-delta isoform X2

      UniProtKB/TrEMBL
      B2RAR6

    19. XM_054359916.1 → XP_054215891.1  elongation factor 1-delta isoform X3

      UniProtKB/TrEMBL
      B2RAR6

    20. XM_054359911.1 → XP_054215886.1  elongation factor 1-delta isoform X1

      UniProtKB/TrEMBL
      B2RAR6

    21. XM_054359943.1 → XP_054215918.1  elongation factor 1-delta isoform X10

      UniProtKB/TrEMBL
      B2RAR6

    22. XM_054359933.1 → XP_054215908.1  elongation factor 1-delta isoform X7

      UniProtKB/TrEMBL
      B2RAR6

    23. XM_054359938.1 → XP_054215913.1  elongation factor 1-delta isoform X9

      UniProtKB/TrEMBL
      B2RAR6

    24. XM_054359919.1 → XP_054215894.1  elongation factor 1-delta isoform X6

      UniProtKB/TrEMBL
      B2RAR6

    25. XM_054359937.1 → XP_054215912.1  elongation factor 1-delta isoform X8

      UniProtKB/TrEMBL
      B2RAR6

    26. XM_054359918.1 → XP_054215893.1  elongation factor 1-delta isoform X5

      UniProtKB/TrEMBL
      B2RAR6

    27. XM_054359923.1 → XP_054215898.1  elongation factor 1-delta isoform X6

      UniProtKB/TrEMBL
      B2RAR6

    28. XM_054359930.1 → XP_054215905.1  elongation factor 1-delta isoform X6

      UniProtKB/TrEMBL
      B2RAR6

    29. XM_054359929.1 → XP_054215904.1  elongation factor 1-delta isoform X6

      UniProtKB/TrEMBL
      B2RAR6

    30. XM_054359928.1 → XP_054215903.1  elongation factor 1-delta isoform X6

      UniProtKB/TrEMBL
      B2RAR6

    31. XM_054359934.1 → XP_054215909.1  elongation factor 1-delta isoform X7

      UniProtKB/TrEMBL
      B2RAR6

    32. XM_054359939.1 → XP_054215914.1  elongation factor 1-delta isoform X9

      UniProtKB/TrEMBL
      B2RAR6

    33. XM_054359922.1 → XP_054215897.1  elongation factor 1-delta isoform X6

      UniProtKB/TrEMBL
      B2RAR6

    34. XM_054359942.1 → XP_054215917.1  elongation factor 1-delta isoform X9

      UniProtKB/TrEMBL
      B2RAR6

    35. XM_054359921.1 → XP_054215896.1  elongation factor 1-delta isoform X6

      UniProtKB/TrEMBL
      B2RAR6

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001130054.1: Suppressed sequence

      Description
      NM_001130054.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P29692.5 GenPept UniProtKB/Swiss-Prot:P29692

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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