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    PI4K2A phosphatidylinositol 4-kinase type 2 alpha [ Homo sapiens (human) ]

    Gene ID: 55361, updated on 4-Jan-2025

    Summary

    Official Symbol
    PI4K2Aprovided by HGNC
    Official Full Name
    phosphatidylinositol 4-kinase type 2 alphaprovided by HGNC
    Primary source
    HGNC:HGNC:30031
    See related
    Ensembl:ENSG00000155252 MIM:609763; AllianceGenome:HGNC:30031
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NEDMSB; PI4KII; PIK42A
    Summary
    Phosphatidylinositolpolyphosphates (PtdInsPs) are centrally involved in many biologic processes, ranging from cell growth and organization of the actin cytoskeleton to endo- and exocytosis. PI4KII phosphorylates PtdIns at the D-4 position, an essential step in the biosynthesis of PtdInsPs (Barylko et al., 2001 [PubMed 11244087]).[supplied by OMIM, Mar 2008]
    Expression
    Ubiquitous expression in placenta (RPKM 11.9), gall bladder (RPKM 10.1) and 25 other tissues See more
    Orthologs
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    Genomic context

    See PI4K2A in Genome Data Viewer
    Location:
    10q24.2
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (97640671..97676434)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (98520873..98556635)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (99400428..99436191)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 10262 Neighboring gene chromosome 10 open reading frame 62 Neighboring gene 4-hydroxy-2-oxoglutarate aldolase 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:99366549-99367050 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:99367051-99367550 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3853 Neighboring gene MORN repeat containing 4 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3854 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:99399170-99399353 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2683 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3855 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3856 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr10:99411103-99412302 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:99435535-99436034 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3857 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr10:99446822-99448021 Neighboring gene arginine vasopressin induced 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3858 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2685 Neighboring gene MARVEL domain containing 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Pr55(Gag) gag Rab27a is required for plasma membrane delivery of PI4K2A and HIV-1 Gag assembly in Jurkat cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Clone Names

    • DKFZp761G1923

    Gene Ontology Provided by GOA

    Items 1 - 20 of 24
    Component Evidence Code Pubs
    part_of BLOC-1 complex PubMed 
    located_in Golgi membrane PubMed 
    located_in cytoplasmic vesicle  
    located_in cytosol  
    located_in dendrite  
    located_in early endosome membrane PubMed 
    is_active_in endosome  
    located_in endosome  
    located_in endosome membrane PubMed 
    located_in glutamatergic synapse  
    located_in growing cell tip  
    located_in lysosomal membrane PubMed 
    located_in membrane PubMed 
    located_in membrane PubMed 
    located_in membrane raft PubMed 
    located_in mitochondrion  
    located_in neuron projection  
    located_in neuronal cell body  
    located_in perikaryon  
    is_active_in plasma membrane  
    located_in plasma membrane PubMed 
    located_in presynaptic active zone  
    located_in presynaptic membrane  
    is_active_in trans-Golgi network  
    Items 1 - 20 of 24

    General protein information

    Preferred Names
    phosphatidylinositol 4-kinase type 2-alpha
    Names
    phosphatidylinositol 4-kinase type II (PI4KII)
    phosphatidylinositol 4-kinase type II-alpha
    NP_060895.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_018425.4 → NP_060895.1  phosphatidylinositol 4-kinase type 2-alpha

      Status: VALIDATED

      Source sequence(s)
      AL355315
      Consensus CDS
      CCDS7469.1
      UniProtKB/Swiss-Prot
      D3DR59, Q9BTU6, Q9NSG8
      Related
      ENSP00000359665.3, ENST00000370631.4
      Conserved Domains (1) summary
      pfam00454
      Location:133 → 429
      PI3_PI4_kinase; Phosphatidylinositol 3- and 4-kinase

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      97640671..97676434
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      98520873..98556635
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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