Replication interactions
Interaction |
Pubs |
Knockdown of tubulin, alpha 1b (TUBA1B) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells |
PubMed
|
Protein interactions
Protein |
Gene |
Interaction |
Pubs |
Envelope surface glycoprotein gp120
|
env
|
The binding of HIV-1 gp120 to CD4+-permissive cells increases the level of acetylated alpha-tubulin in a CD4-dependent manner; overexpression of Histone Deacetylase 6 (HDAC6) inhibits the acetylation of alpha-tubulin and prevents HIV-1-cell fusion |
PubMed
|
Envelope surface glycoprotein gp160, precursor
|
env
|
Treatment of cells with actin-depolymerizing agents or tubulin polymerization inhibitors largely reduces the percentage of cells with capped HIV-1 Gag and Env, indicating an intact actin and tubulin cytoskeleton is required for efficient assembly of HIV-1 |
PubMed
|
Pr55(Gag)
|
gag
|
Treatment of cells with actin-depolymerizing agents or tubulin polymerization inhibitors largely reduces the percentage of cells with capped HIV-1 Gag and Env, indicating an intact actin and tubulin cytoskeleton is required for efficient assembly of HIV-1 |
PubMed
|
Rev
|
rev
|
HIV-1 Rev interacting protein, TUBA1B, is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells |
PubMed
|
|
rev
|
Rev acts to depolymerize microtubules that are formed by tubulin, an effect that is observed during HIV-1 infection |
PubMed
|
Tat
|
tat
|
HIV-1 Tat K29A, K50R, and K51R lysine mutations downregulate the proportion of soluble tubulin in cells, while the majority of other lysine mutations upregulate the percentage of soluble tubulin compared with the wild-type |
PubMed
|
|
tat
|
HIV-1 Tat (specifically, amino acids 38-72), enhances tubulin polymerization and triggers the mitochondrial pathway to induce T cell apoptosis as shown in vitro by the release of cytochrome c from isolated mitochondria |
PubMed
|
|
tat
|
HIV-1 Tat (amino acids 36-39) binds tubulin alpha/beta dimers and polymerized microtubules leading to the alteration of microtubule dynamics and activation of a mitochondria-dependent apoptotic pathway that is facilitated by the Bcl-2 relative Bim |
PubMed
|
integrase
|
gag-pol
|
Co-immunoprecipitation shows interaction of HIV-1 IN with alpha-tubulin |
PubMed
|
retropepsin
|
gag-pol
|
Positional proteomics analysis identifies the cleavage of human tubulin, alpha 1b (TUBA1B) at amino acid residues 67-68 and 202-203 by the HIV-1 protease |
PubMed
|
Go to the HIV-1, Human Interaction Database