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    RICTOR RPTOR independent companion of MTOR complex 2 [ Homo sapiens (human) ]

    Gene ID: 253260, updated on 4-Jan-2025

    Summary

    Official Symbol
    RICTORprovided by HGNC
    Official Full Name
    RPTOR independent companion of MTOR complex 2provided by HGNC
    Primary source
    HGNC:HGNC:28611
    See related
    Ensembl:ENSG00000164327 MIM:609022; AllianceGenome:HGNC:28611
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PIA; AVO3; hAVO3
    Summary
    RICTOR and MTOR (FRAP1; MIM 601231) are components of a protein complex that integrates nutrient- and growth factor-derived signals to regulate cell growth (Sarbassov et al., 2004 [PubMed 15268862]).[supplied by OMIM, Mar 2008]
    Expression
    Ubiquitous expression in bone marrow (RPKM 9.8), testis (RPKM 7.0) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See RICTOR in Genome Data Viewer
    Location:
    5p13.1
    Exon count:
    41
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (38937920..39074399, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (39187325..39323906, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (38938022..39074501, complement)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene OSMR divergent transcript Neighboring gene transmembrane protein 126A pseudogene Neighboring gene Sharpr-MPRA regulatory region 7781 Neighboring gene uncharacterized LOC107986414 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:38810677-38811177 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr5:38830048-38831247 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:38878837-38879338 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:38879339-38879838 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:38908235-38908735 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:38907734-38908234 Neighboring gene NANOG hESC enhancer GRCh37_chr5:38916726-38917255 Neighboring gene oncostatin M receptor Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_84767 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_84768 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:39011967-39012173 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:39073334-39073860 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:39074387-39074913 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22495 Neighboring gene androgen induced 1 pseudogene 1 Neighboring gene Sharpr-MPRA regulatory region 14991 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22496 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22497 Neighboring gene FYN binding protein 1 Neighboring gene Sharpr-MPRA regulatory region 12253 Neighboring gene golgin A5 pseudogene 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:39220741-39221242 Neighboring gene Sharpr-MPRA regulatory region 14491 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:39242438-39242627 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22498 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:39283272-39283436 Neighboring gene complement C9

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    BioGRID CRISPR Screen Phenotypes (311 hits/1303 screens)

    EBI GWAS Catalog

    Description
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • KIAA1999, MGC39830, DKFZp686B11164

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in TORC2 signaling  
    involved_in TORC2 signaling PubMed 
    involved_in actin cytoskeleton organization PubMed 
    involved_in cellular response to nutrient levels PubMed 
    involved_in cytoskeleton organization PubMed 
    involved_in embryo development ending in birth or egg hatching  
    involved_in lipid biosynthetic process  
    involved_in negative regulation of apoptotic process PubMed 
    involved_in peptidyl-serine phosphorylation PubMed 
    involved_in positive regulation of TOR signaling PubMed 
    involved_in positive regulation of actin filament polymerization  
    involved_in positive regulation of cell growth PubMed 
    involved_in positive regulation of endothelial cell proliferation  
    involved_in positive regulation of peptidyl-tyrosine phosphorylation  
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  
    involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction PubMed 
    involved_in regulation of actin cytoskeleton organization PubMed 
    involved_in regulation of establishment of cell polarity  
    involved_in regulation of gene expression  
    involved_in regulation of inflammatory response  
    involved_in regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction PubMed 
    Component Evidence Code Pubs
    is_active_in Golgi apparatus PubMed 
    part_of TORC2 complex  
    part_of TORC2 complex PubMed 
    part_of TORC2 complex PubMed 
    located_in cytosol  
    is_active_in endoplasmic reticulum PubMed 
    is_active_in lysosome PubMed 
    is_active_in plasma membrane PubMed 

    General protein information

    Preferred Names
    rapamycin-insensitive companion of mTOR
    Names
    AVO3 homolog
    TORC2-specific protein AVO3
    pianissimo

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001285439.2 → NP_001272368.1  rapamycin-insensitive companion of mTOR isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an additional in-frame coding exon compared to variant 1. The resulting longer isoform (2) has an internal protein segment not found in isoform 1.
      Source sequence(s)
      AC008964, AC026713, AC109467
      Consensus CDS
      CCDS68861.1
      UniProtKB/Swiss-Prot
      Q6R327
      Related
      ENSP00000296782.5, ENST00000296782.10
      Conserved Domains (5) summary
      pfam14663
      Location:747 → 853
      RasGEF_N_2; Rapamycin-insensitive companion of mTOR RasGEF_N domain
      pfam14664
      Location:60 → 437
      RICTOR_N; Rapamycin-insensitive companion of mTOR, N-term
      pfam14665
      Location:1084 → 1188
      RICTOR_phospho; Rapamycin-insensitive companion of mTOR, phosphorylation-site
      pfam14666
      Location:525 → 740
      RICTOR_M; Rapamycin-insensitive companion of mTOR, middle domain
      pfam14668
      Location:922 → 989
      RICTOR_V; Rapamycin-insensitive companion of mTOR, domain 5
    2. NM_001285440.2 → NP_001272369.1  rapamycin-insensitive companion of mTOR isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses in-frame acceptor splice sites at 2 internal exons compared to variant 1. The resulting isoform (3) is shorter than isoform 1.
      Source sequence(s)
      AC008964, AC026713, AC109467
      UniProtKB/Swiss-Prot
      Q6R327
      Conserved Domains (5) summary
      pfam14663
      Location:462 → 568
      RasGEF_N_2; Rapamycin-insensitive companion of mTOR RasGEF_N domain
      pfam14664
      Location:3 → 152
      RICTOR_N; Rapamycin-insensitive companion of mTOR, N-term
      pfam14665
      Location:799 → 903
      RICTOR_phospho; Rapamycin-insensitive companion of mTOR, phosphorylation-site
      pfam14666
      Location:240 → 455
      RICTOR_M; Rapamycin-insensitive companion of mTOR, middle domain
      pfam14668
      Location:637 → 704
      RICTOR_V; Rapamycin-insensitive companion of mTOR, domain 5
    3. NM_152756.5 → NP_689969.2  rapamycin-insensitive companion of mTOR isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the predominant transcript and encodes isoform 1.
      Source sequence(s)
      AC008964, AC026713, AC109467
      Consensus CDS
      CCDS34148.1
      UniProtKB/Swiss-Prot
      B2RNX0, B7ZMF7, Q68DT5, Q6R327, Q86UB7, Q8N3A0, Q8NCM6
      Related
      ENSP00000349959.3, ENST00000357387.8
      Conserved Domains (5) summary
      pfam14663
      Location:747 → 853
      RasGEF_N_2; Rapamycin-insensitive companion of mTOR RasGEF_N domain
      pfam14664
      Location:58 → 437
      RICTOR_N; Rapamycin-insensitive companion of mTOR, N-term
      pfam14665
      Location:1085 → 1188
      RICTOR_phospho; Rapamycin-insensitive companion of mTOR, phosphorylation-site
      pfam14666
      Location:637 → 740
      RICTOR_M; Rapamycin-insensitive companion of mTOR, middle domain
      pfam14668
      Location:922 → 991
      RICTOR_V; Rapamycin-insensitive companion of mTOR, domain 5

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      38937920..39074399 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047417070.1 → XP_047273026.1  rapamycin-insensitive companion of mTOR isoform X8

    2. XM_017009312.2 → XP_016864801.1  rapamycin-insensitive companion of mTOR isoform X3

      UniProtKB/TrEMBL
      D6R9S6
      Related
      ENSP00000423162.2, ENST00000514735.2
    3. XM_047417069.1 → XP_047273025.1  rapamycin-insensitive companion of mTOR isoform X5

    4. XM_017009311.2 → XP_016864800.1  rapamycin-insensitive companion of mTOR isoform X1

    5. XM_006714463.4 → XP_006714526.1  rapamycin-insensitive companion of mTOR isoform X6

      Conserved Domains (5) summary
      pfam14663
      Location:747 → 853
      RasGEF_N_2; Rapamycin-insensitive companion of mTOR RasGEF_N domain
      pfam14664
      Location:60 → 437
      RICTOR_N; Rapamycin-insensitive companion of mTOR, N-term
      pfam14665
      Location:1084 → 1188
      RICTOR_phospho; Rapamycin-insensitive companion of mTOR, phosphorylation-site
      pfam14666
      Location:525 → 740
      RICTOR_M; Rapamycin-insensitive companion of mTOR, middle domain
      pfam14668
      Location:922 → 989
      RICTOR_V; Rapamycin-insensitive companion of mTOR, domain 5
    6. XM_011514005.3 → XP_011512307.1  rapamycin-insensitive companion of mTOR isoform X2

      UniProtKB/TrEMBL
      A0AA34QVX7
      Related
      ENSP00000518562.1, ENST00000711063.1
      Conserved Domains (5) summary
      pfam14663
      Location:747 → 853
      RasGEF_N_2; Rapamycin-insensitive companion of mTOR RasGEF_N domain
      pfam14664
      Location:60 → 437
      RICTOR_N; Rapamycin-insensitive companion of mTOR, N-term
      pfam14665
      Location:1084 → 1188
      RICTOR_phospho; Rapamycin-insensitive companion of mTOR, phosphorylation-site
      pfam14666
      Location:525 → 740
      RICTOR_M; Rapamycin-insensitive companion of mTOR, middle domain
      pfam14668
      Location:922 → 989
      RICTOR_V; Rapamycin-insensitive companion of mTOR, domain 5
    7. XM_047417068.1 → XP_047273024.1  rapamycin-insensitive companion of mTOR isoform X4

    8. XM_011514006.4 → XP_011512308.1  rapamycin-insensitive companion of mTOR isoform X7

      Conserved Domains (5) summary
      pfam14663
      Location:684 → 790
      RasGEF_N_2; Rapamycin-insensitive companion of mTOR RasGEF_N domain
      pfam14664
      Location:2 → 374
      RICTOR_N; Rapamycin-insensitive companion of mTOR, N-term
      pfam14665
      Location:1021 → 1125
      RICTOR_phospho; Rapamycin-insensitive companion of mTOR, phosphorylation-site
      pfam14666
      Location:462 → 677
      RICTOR_M; Rapamycin-insensitive companion of mTOR, middle domain
      pfam14668
      Location:859 → 926
      RICTOR_V; Rapamycin-insensitive companion of mTOR, domain 5

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      39187325..39323906 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054352286.1 → XP_054208261.1  rapamycin-insensitive companion of mTOR isoform X8

    2. XM_054352281.1 → XP_054208256.1  rapamycin-insensitive companion of mTOR isoform X3

      UniProtKB/TrEMBL
      D6R9S6
    3. XM_054352283.1 → XP_054208258.1  rapamycin-insensitive companion of mTOR isoform X5

    4. XM_054352279.1 → XP_054208254.1  rapamycin-insensitive companion of mTOR isoform X1

    5. XM_054352284.1 → XP_054208259.1  rapamycin-insensitive companion of mTOR isoform X6

    6. XM_054352280.1 → XP_054208255.1  rapamycin-insensitive companion of mTOR isoform X2

      UniProtKB/TrEMBL
      A0AA34QVX7
    7. XM_054352282.1 → XP_054208257.1  rapamycin-insensitive companion of mTOR isoform X4

    8. XM_054352285.1 → XP_054208260.1  rapamycin-insensitive companion of mTOR isoform X7

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