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    MAP3K12 mitogen-activated protein kinase kinase kinase 12 [ Homo sapiens (human) ]

    Gene ID: 7786, updated on 4-Jan-2025

    Summary

    Official Symbol
    MAP3K12provided by HGNC
    Official Full Name
    mitogen-activated protein kinase kinase kinase 12provided by HGNC
    Primary source
    HGNC:HGNC:6851
    See related
    Ensembl:ENSG00000139625 MIM:600447; AllianceGenome:HGNC:6851
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DLK; MUK; ZPK; ZPKP1; MEKK12; HP09298
    Summary
    This gene encodes a member of the serine/threonine protein kinase family. This kinase contains a leucine-zipper domain and is predominately expressed in neuronal cells. The phosphorylation state of this kinase in synaptic terminals was shown to be regulated by membrane depolarization via calcineurin. This kinase forms heterodimers with leucine zipper containing transcription factors, such as cAMP responsive element binding protein (CREB) and MYC, and thus may play a regulatory role in PKA or retinoic acid induced neuronal differentiation. Alternatively spliced transcript variants encoding different proteins have been described.[provided by RefSeq, Jul 2010]
    Expression
    Ubiquitous expression in urinary bladder (RPKM 14.0), brain (RPKM 12.1) and 25 other tissues See more
    Orthologs
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    Genomic context

    See MAP3K12 in Genome Data Viewer
    Location:
    12q13.13
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (53479669..53501539, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (53445716..53466177, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (53873453..53893242, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6422 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4511 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4512 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4513 Neighboring gene proline rich 13 Neighboring gene poly(rC) binding protein 2 Neighboring gene PCBP2 overlapping transcript 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:53876139-53876652 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4514 Neighboring gene Sharpr-MPRA regulatory region 1043 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4515 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6423 Neighboring gene Sharpr-MPRA regulatory region 3466 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:53902821-53903053 Neighboring gene uncharacterized LOC100652999 Neighboring gene ATF7-NPFF readthrough Neighboring gene ReSE screen-validated silencer GRCh37_chr12:53909665-53909906 Neighboring gene TARBP2 subunit of RISC loading complex Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:53910873-53911372 Neighboring gene neuropeptide FF-amide peptide precursor Neighboring gene activating transcription factor 7

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding  
    enables protein binding PubMed 
    enables protein homodimerization activity  
    enables protein kinase activity PubMed 
    enables protein kinase binding PubMed 
    enables protein serine kinase activity  
    enables protein serine/threonine kinase activator activity  
    enables protein serine/threonine kinase activity  
    enables protein serine/threonine kinase activity PubMed 
    Process Evidence Code Pubs
    involved_in JNK cascade  
    involved_in JNK cascade PubMed 
    involved_in intracellular signal transduction PubMed 
    involved_in negative regulation of motor neuron apoptotic process  
    involved_in peptidyl-serine phosphorylation  
    involved_in positive regulation of DNA-templated transcription PubMed 
    involved_in positive regulation of ERK1 and ERK2 cascade PubMed 
    involved_in positive regulation of JUN kinase activity  
    involved_in positive regulation of protein kinase activity  
    involved_in post-translational protein modification  
    involved_in protein autophosphorylation PubMed 
    involved_in protein phosphorylation PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm  
    located_in cytosol  
    located_in growth cone  
    located_in membrane PubMed 
    located_in plasma membrane  

    General protein information

    Preferred Names
    mitogen-activated protein kinase kinase kinase 12
    Names
    MAPK-upstream kinase
    dual leucine zipper bearing kinase
    dual leucine zipper kinase DLK
    leucine zipper protein kinase
    mixed lineage kinase
    protein kinase MUK
    NP_001180440.1
    NP_006292.3
    XP_005269195.1
    XP_005269197.1
    XP_006719651.1
    XP_011537027.1
    XP_016875445.1
    XP_047285478.1
    XP_047285479.1
    XP_054229158.1
    XP_054229159.1
    XP_054229160.1
    XP_054229161.1
    XP_054229162.1
    XP_054229163.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001193511.2 → NP_001180440.1  mitogen-activated protein kinase kinase kinase 12 isoform 1

      See identical proteins and their annotated locations for NP_001180440.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC023509, AK094195, BC050050
      Consensus CDS
      CCDS55831.1
      UniProtKB/Swiss-Prot
      Q12852
      Related
      ENSP00000449038.1, ENST00000547488.6
      Conserved Domains (2) summary
      smart00219
      Location:165 → 397
      TyrKc; Tyrosine kinase, catalytic domain
      cd14059
      Location:164 → 400
      STKc_MAP3K12_13; Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinases 12 and 13
    2. NM_006301.4 → NP_006292.3  mitogen-activated protein kinase kinase kinase 12 isoform 2

      See identical proteins and their annotated locations for NP_006292.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region compared to variant 1. The resulting protein (isoform 2) is shorter but has the same N- and C-termini compared to isoform 1.
      Source sequence(s)
      AC023509, AK094195, U07358
      Consensus CDS
      CCDS8860.1
      UniProtKB/Swiss-Prot
      B3KSS9, G3V1Y2, Q12852, Q86VQ5, Q8WY25
      Related
      ENSP00000267079.2, ENST00000267079.6
      Conserved Domains (2) summary
      smart00219
      Location:132 → 364
      TyrKc; Tyrosine kinase, catalytic domain
      cd14059
      Location:131 → 367
      STKc_MAP3K12_13; Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinases 12 and 13

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      53479669..53501539 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011538725.4 → XP_011537027.1  mitogen-activated protein kinase kinase kinase 12 isoform X1

      See identical proteins and their annotated locations for XP_011537027.1

      UniProtKB/Swiss-Prot
      Q12852
      Conserved Domains (2) summary
      smart00219
      Location:165 → 397
      TyrKc; Tyrosine kinase, catalytic domain
      cd14059
      Location:164 → 400
      STKc_MAP3K12_13; Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinases 12 and 13
    2. XM_005269138.5 → XP_005269195.1  mitogen-activated protein kinase kinase kinase 12 isoform X1

      See identical proteins and their annotated locations for XP_005269195.1

      UniProtKB/Swiss-Prot
      Q12852
      Related
      ENSP00000448689.1, ENST00000547035.5
      Conserved Domains (2) summary
      smart00219
      Location:165 → 397
      TyrKc; Tyrosine kinase, catalytic domain
      cd14059
      Location:164 → 400
      STKc_MAP3K12_13; Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinases 12 and 13
    3. XM_017019956.3 → XP_016875445.1  mitogen-activated protein kinase kinase kinase 12 isoform X2

      UniProtKB/Swiss-Prot
      B3KSS9, G3V1Y2, Q12852, Q86VQ5, Q8WY25
      Conserved Domains (2) summary
      smart00219
      Location:132 → 364
      TyrKc; Tyrosine kinase, catalytic domain
      cd14059
      Location:131 → 367
      STKc_MAP3K12_13; Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinases 12 and 13
    4. XM_006719588.5 → XP_006719651.1  mitogen-activated protein kinase kinase kinase 12 isoform X1

      See identical proteins and their annotated locations for XP_006719651.1

      UniProtKB/Swiss-Prot
      Q12852
      Conserved Domains (2) summary
      smart00219
      Location:165 → 397
      TyrKc; Tyrosine kinase, catalytic domain
      cd14059
      Location:164 → 400
      STKc_MAP3K12_13; Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinases 12 and 13
    5. XM_047429523.1 → XP_047285479.1  mitogen-activated protein kinase kinase kinase 12 isoform X4

    6. XM_047429522.1 → XP_047285478.1  mitogen-activated protein kinase kinase kinase 12 isoform X3

    7. XM_005269140.3 → XP_005269197.1  mitogen-activated protein kinase kinase kinase 12 isoform X5

      UniProtKB/TrEMBL
      F8VUG4
      Related
      ENSP00000447889.1, ENST00000552365.1
      Conserved Domains (2) summary
      smart00219
      Location:165 → 397
      TyrKc; Tyrosine kinase, catalytic domain
      cd14059
      Location:164 → 400
      STKc_MAP3K12_13; Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinases 12 and 13

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      53445716..53466177 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054373184.1 → XP_054229159.1  mitogen-activated protein kinase kinase kinase 12 isoform X1

    2. XM_054373183.1 → XP_054229158.1  mitogen-activated protein kinase kinase kinase 12 isoform X1

    3. XM_054373186.1 → XP_054229161.1  mitogen-activated protein kinase kinase kinase 12 isoform X2

      UniProtKB/Swiss-Prot
      B3KSS9, G3V1Y2, Q12852, Q86VQ5, Q8WY25
    4. XM_054373185.1 → XP_054229160.1  mitogen-activated protein kinase kinase kinase 12 isoform X1

    5. XM_054373187.1 → XP_054229162.1  mitogen-activated protein kinase kinase kinase 12 isoform X4

    6. XM_054373188.1 → XP_054229163.1  mitogen-activated protein kinase kinase kinase 12 isoform X5

      UniProtKB/TrEMBL
      F8VUG4
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