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    Nr3c2 nuclear receptor subfamily 3, group C, member 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25672, updated on 9-Dec-2024

    Summary

    Official Symbol
    Nr3c2provided by RGD
    Official Full Name
    nuclear receptor subfamily 3, group C, member 2provided by RGD
    Primary source
    RGD:3094
    See related
    EnsemblRapid:ENSRNOG00000034007 AllianceGenome:RGD:3094
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    MCR; Mlr
    Summary
    Enables several functions, including DNA binding activity; histone acetyltransferase binding activity; and transcription coactivator binding activity. Involved in several processes, including nuclear receptor-mediated corticosteroid signaling pathway; positive regulation of transcription by RNA polymerase II; and response to mineralocorticoid. Located in cytoplasm and nucleus. Is active in glutamatergic synapse; postsynaptic density, intracellular component; and presynaptic active zone cytoplasmic component. Used to study alcohol use disorder; morphine dependence; and polycystic ovary syndrome. Biomarker of alcohol dependence; fetal alcohol spectrum disorder; obesity; and steatotic liver disease. Human ortholog(s) of this gene implicated in autosomal dominant pseudohypoaldosteronism type 1 and pseudohypoaldosteronism. Orthologous to human NR3C2 (nuclear receptor subfamily 3 group C member 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 106.1), Heart (RPKM 105.8) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Nr3c2 in Genome Data Viewer
    Location:
    19q11
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (47619853..47964089, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (30715634..31059885, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (34408275..34761003, complement)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene membrane-associated progesterone receptor component 1 pseudogene Neighboring gene Rho GTPase activating protein 10 Neighboring gene uncharacterized LOC134483345 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene uncharacterized LOC134483346 Neighboring gene ribosomal protein S27a, pseudogene 6 Neighboring gene uncharacterized LOC102553276 Neighboring gene small nucleolar RNA SNORA17

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity  
    enables DNA-binding transcription factor activity PubMed 
    enables TBP-class protein binding  
    enables double-stranded DNA binding PubMed 
    enables estrogen response element binding  
    enables histone acetyltransferase binding PubMed 
    enables identical protein binding PubMed 
    enables nuclear receptor activity  
    enables nuclear steroid receptor activity PubMed 
    enables protein binding PubMed 
    enables protein-containing complex binding PubMed 
    enables sequence-specific DNA binding PubMed 
    enables sequence-specific DNA binding  
    enables sequence-specific double-stranded DNA binding  
    enables steroid binding  
    enables steroid binding PubMed 
    enables steroid binding  
    enables transcription coactivator binding PubMed 
    enables zinc ion binding  
    Process Evidence Code Pubs
    involved_in angiotensin-activated signaling pathway  
    involved_in cellular response to aldosterone PubMed 
    involved_in cellular response to aldosterone PubMed 
    acts_upstream_of_or_within intracellular sodium ion homeostasis  
    involved_in locomotory behavior PubMed 
    involved_in nuclear receptor-mediated corticosteroid signaling pathway PubMed 
    involved_in nuclear receptor-mediated steroid hormone signaling pathway  
    involved_in positive regulation of non-canonical NF-kappaB signal transduction  
    involved_in positive regulation of transcription by RNA polymerase II PubMed 
    involved_in potassium ion homeostasis  
    involved_in presynaptic modulation of chemical synaptic transmission  
    involved_in regulation of DNA-templated transcription  
    involved_in regulation of blood volume by renal aldosterone  
    involved_in regulation of cell population proliferation PubMed 
    involved_in regulation of postsynaptic membrane potential  
    involved_in regulation of potassium:proton exchanging ATPase activity  
    involved_in regulation of transcription by RNA polymerase II  
    acts_upstream_of_or_within renal sodium excretion  
    involved_in response to alcohol PubMed 
    involved_in response to corticosterone PubMed 
    involved_in signal transduction  
    Component Evidence Code Pubs
    is_active_in GABA-ergic synapse  
    located_in chromatin  
    located_in cytoplasm PubMed 
    located_in cytoplasm  
    located_in endoplasmic reticulum membrane  
    is_active_in glutamatergic synapse PubMed 
    is_active_in glutamatergic synapse  
    located_in nucleoplasm  
    is_active_in nucleus  
    located_in nucleus PubMed 
    located_in nucleus  
    is_active_in postsynaptic density, intracellular component PubMed 
    is_active_in presynaptic active zone cytoplasmic component PubMed 
    part_of receptor complex  

    General protein information

    Preferred Names
    mineralocorticoid receptor
    Names
    MR
    Mineralocorticoid receptor (aldosterone receptor)

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001395077.2NP_001382006.1  mineralocorticoid receptor isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000019
      UniProtKB/Swiss-Prot
      P22199, Q63763, Q64174
      Conserved Domains (2) summary
      cd07075
      Location:734981
      NR_LBD_MR; Ligand binding domain of the mineralocorticoid receptor, a member of the nuclear receptor superfamily
      cd07172
      Location:600674
      NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
    2. NM_001429945.1NP_001416874.1  mineralocorticoid receptor isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000019
      UniProtKB/Swiss-Prot
      P22199, Q63763, Q64174
    3. NM_001429946.1NP_001416875.1  mineralocorticoid receptor isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000019
      UniProtKB/Swiss-Prot
      P22199, Q63763, Q64174
      UniProtKB/TrEMBL
      F1M6V2
    4. NM_013131.3NP_037263.2  mineralocorticoid receptor isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000019
      UniProtKB/Swiss-Prot
      P22199, Q63763, Q64174
      Related
      ENSRNOP00000081905.1, ENSRNOT00000096148.2
      Conserved Domains (2) summary
      cd07075
      Location:734981
      NR_LBD_MR; Ligand binding domain of the mineralocorticoid receptor, a member of the nuclear receptor superfamily
      cd07172
      Location:600674
      NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      47619853..47964089 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039097525.2XP_038953453.1  mineralocorticoid receptor isoform X1

      UniProtKB/Swiss-Prot
      P22199, Q63763, Q64174
      UniProtKB/TrEMBL
      F1M6V2
      Related
      ENSRNOP00000045942.5, ENSRNOT00000052018.6
      Conserved Domains (2) summary
      cd07075
      Location:738985
      NR_LBD_MR; Ligand binding domain of the mineralocorticoid receptor, a member of the nuclear receptor superfamily
      cd07172
      Location:600678
      NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
    2. XM_039097524.2XP_038953452.1  mineralocorticoid receptor isoform X1

      UniProtKB/Swiss-Prot
      P22199, Q63763, Q64174
      UniProtKB/TrEMBL
      F1M6V2
      Conserved Domains (2) summary
      cd07075
      Location:738985
      NR_LBD_MR; Ligand binding domain of the mineralocorticoid receptor, a member of the nuclear receptor superfamily
      cd07172
      Location:600678
      NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
    3. XM_039097523.2XP_038953451.1  mineralocorticoid receptor isoform X1

      Conserved Domains (2) summary
      cd07075
      Location:738985
      NR_LBD_MR; Ligand binding domain of the mineralocorticoid receptor, a member of the nuclear receptor superfamily
      cd07172
      Location:600678
      NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
    4. XM_039097526.2XP_038953454.1  mineralocorticoid receptor isoform X2

      Related
      ENSRNOP00000109891.1, ENSRNOT00000144737.1
      Conserved Domains (2) summary
      cd07075
      Location:734981
      NR_LBD_MR; Ligand binding domain of the mineralocorticoid receptor, a member of the nuclear receptor superfamily
      cd07172
      Location:600674
      NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers
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