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    Il7 interleukin 7 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25647, updated on 9-Dec-2024

    Summary

    Official Symbol
    Il7provided by RGD
    Official Full Name
    interleukin 7provided by RGD
    Primary source
    RGD:2904
    See related
    EnsemblRapid:ENSRNOG00000011973 AllianceGenome:RGD:2904
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable cytokine activity and growth factor activity. Involved in cellular response to hypoxia and response to X-ray. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Used to study high grade glioma. Biomarker of periodontal disease. Human ortholog(s) of this gene implicated in epidermodysplasia verruciformis. Orthologous to human IL7 (interleukin 7). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Spleen (RPKM 50.3), Thymus (RPKM 49.0) and 6 other tissues See more
    Orthologs
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    Genomic context

    See Il7 in Genome Data Viewer
    Location:
    2q23
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (96142523..96186282)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (94235219..94280075)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (96427884..96474979)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108350232 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene uncharacterized LOC120100774 Neighboring gene zinc finger, C2HC-type containing 1A Neighboring gene small nucleolar RNA SNORA17

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cytokine activity  
    enables cytokine activity  
    enables cytokine activity  
    enables growth factor activity  
    enables growth factor activity  
    enables growth factor activity  
    enables interleukin-7 receptor binding  
    Items 1 - 25 of 42
    Process Evidence Code Pubs
    involved_in B cell proliferation  
    acts_upstream_of B cell proliferation  
    involved_in T cell lineage commitment  
    acts_upstream_of_or_within T cell lineage commitment  
    involved_in bone resorption  
    acts_upstream_of_or_within bone resorption  
    involved_in bone resorption  
    involved_in cellular response to hypoxia PubMed 
    involved_in cytokine-mediated signaling pathway  
    involved_in extrinsic apoptotic signaling pathway  
    acts_upstream_of extrinsic apoptotic signaling pathway  
    involved_in homeostasis of number of cells within a tissue  
    acts_upstream_of_or_within homeostasis of number of cells within a tissue  
    involved_in immune response  
    involved_in interleukin-7-mediated signaling pathway  
    involved_in interleukin-7-mediated signaling pathway  
    involved_in negative regulation of apoptotic process  
    acts_upstream_of_or_within negative regulation of catalytic activity  
    acts_upstream_of_or_within negative regulation of extrinsic apoptotic signaling pathway  
    involved_in negative regulation of extrinsic apoptotic signaling pathway in absence of ligand  
    acts_upstream_of_or_within negative regulation of extrinsic apoptotic signaling pathway in absence of ligand  
    involved_in organ growth  
    acts_upstream_of organ growth  
    involved_in positive regulation of B cell differentiation  
    acts_upstream_of_or_within positive regulation of B cell differentiation  
    involved_in positive regulation of B cell proliferation  
    acts_upstream_of_or_within positive regulation of B cell proliferation  
    involved_in positive regulation of B cell proliferation  
    involved_in positive regulation of T cell differentiation  
    acts_upstream_of_or_within positive regulation of T cell differentiation  
    involved_in positive regulation of T cell differentiation  
    involved_in positive regulation of chemokine production  
    involved_in positive regulation of chemokine production  
    involved_in positive regulation of cytokine-mediated signaling pathway  
    involved_in positive regulation of cytokine-mediated signaling pathway  
    acts_upstream_of_or_within positive regulation of gene expression  
    involved_in positive regulation of organ growth  
    acts_upstream_of_or_within positive regulation of organ growth  
    acts_upstream_of_or_within regulation of gene expression  
    acts_upstream_of_or_within regulation of peptidyl-tyrosine phosphorylation  
    involved_in response to X-ray PubMed 
    involved_in signal transduction  
    Items 1 - 25 of 42
    Component Evidence Code Pubs
    located_in extracellular region  
    located_in extracellular space  
    is_active_in extracellular space  
    located_in extracellular space  

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013110.3NP_037242.2  interleukin-7 precursor

      See identical proteins and their annotated locations for NP_037242.2

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/Swiss-Prot
      P56478
      UniProtKB/TrEMBL
      Q91Y32
      Related
      ENSRNOP00000097908.1, ENSRNOT00000095233.2
      Conserved Domains (1) summary
      cl11602
      Location:27150
      IL7; Interleukin 7/9 family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      96142523..96186282
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063281372.1XP_063137442.1  interleukin-7 isoform X1

    2. XM_006232139.4XP_006232201.1  interleukin-7 isoform X1

      See identical proteins and their annotated locations for XP_006232201.1

      Conserved Domains (1) summary
      cl11602
      Location:27120
      IL7; Interleukin 7/9 family
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