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    Amy1 amylase alpha 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 24203, updated on 9-Dec-2024

    Summary

    Official Symbol
    Amy1provided by RGD
    Official Full Name
    amylase alpha 1provided by RGD
    Primary source
    RGD:2113
    See related
    EnsemblRapid:ENSRNOG00000064517 AllianceGenome:RGD:2113
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Amy1a
    Summary
    Predicted to enable alpha-amylase activity. Predicted to be involved in carbohydrate metabolic process. Located in extracellular space. Orthologous to several human genes including AMY2B (amylase alpha 2B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 2325.4) and Spleen (RPKM 717.1) See more
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    Genomic context

    See Amy1 in Genome Data Viewer
    Location:
    2q42
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (204071101..204085910, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (201382678..201397487, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (216428709..216443518, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene amylase 2a3 Neighboring gene pancreatic alpha-amylase-like Neighboring gene uncharacterized LOC134485951 Neighboring gene RNA-binding region (RNP1, RRM) containing 3 Neighboring gene ribosomal protein L5, pseudogene 7

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables alpha-amylase activity  
    enables alpha-amylase activity PubMed 
    enables amylase activity  
    enables metal ion binding  
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process  
    involved_in response to bacterium  
    Component Evidence Code Pubs
    is_active_in extracellular space  
    located_in extracellular space PubMed 
    located_in extracellular space  

    General protein information

    Preferred Names
    alpha-amylase 1
    Names
    amylase 1, salivary
    amylase, alpha 1A (salivary)
    NP_001010970.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001010970.1NP_001010970.1  alpha-amylase 1 precursor

      See identical proteins and their annotated locations for NP_001010970.1

      Status: PROVISIONAL

      Source sequence(s)
      AB057450
      UniProtKB/TrEMBL
      A0A8I6A5R3, A6HV62, A6HV63, Q99N59
      Related
      ENSRNOP00000088062.1, ENSRNOT00000098690.2
      Conserved Domains (3) summary
      cd11317
      Location:35426
      AmyAc_bac_euk_AmyA; Alpha amylase catalytic domain found in bacterial and eukaryotic Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase)
      smart00632
      Location:432520
      Aamy_C; Aamy_C domain
      COG0366
      Location:56325
      AmyA; Glycosidase [Carbohydrate transport and metabolism]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      204071101..204085910 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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