U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    Trpm4 transient receptor potential cation channel, subfamily M, member 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 171143, updated on 4-Jan-2025

    Summary

    Official Symbol
    Trpm4provided by RGD
    Official Full Name
    transient receptor potential cation channel, subfamily M, member 4provided by RGD
    Primary source
    RGD:620244
    See related
    EnsemblRapid:ENSRNOG00000020714 AllianceGenome:RGD:620244
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Mls2s; LTrpC-4
    Summary
    Enables calcium-activated cation channel activity. Involved in several processes, including long-term memory; negative regulation of osteoblast differentiation; and regulation of blood circulation. Located in several cellular components, including Golgi apparatus; endoplasmic reticulum; and neuronal cell body. Biomarker of cardiac arrest. Human ortholog(s) of this gene implicated in erythrokeratodermia variabilis et progressiva 6 and progressive familial heart block type IB. Orthologous to human TRPM4 (transient receptor potential cation channel subfamily M member 4). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Lung (RPKM 54.2), Muscle (RPKM 33.7) and 9 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Trpm4 in Genome Data Viewer
    Location:
    1q22
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (104918462..104949453, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (95781805..95812095, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (101293300..101323484, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 6, member 16 Neighboring gene CD37 molecule Neighboring gene uncharacterized LOC134483104 Neighboring gene solute carrier family 6 member 21 Neighboring gene PTPRF interacting protein alpha 3 Neighboring gene histidine rich calcium binding protein Neighboring gene uncharacterized LOC120097162

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding  
    enables ATP binding  
    enables calcium channel activity  
    enables calcium channel activity  
    enables calcium ion binding  
    enables calcium ion binding  
    enables calcium ion binding  
    enables calcium-activated cation channel activity  
    enables calcium-activated cation channel activity PubMed 
    enables calcium-activated cation channel activity  
    enables calcium-activated cation channel activity  
    enables calmodulin binding  
    enables identical protein binding  
    enables monoatomic ion channel activity  
    enables protein binding PubMed 
    Items 1 - 25 of 53
    Process Evidence Code Pubs
    involved_in adaptive immune response  
    involved_in calcium ion transmembrane transport  
    acts_upstream_of_or_within calcium ion transport  
    involved_in calcium-mediated signaling  
    involved_in calcium-mediated signaling  
    involved_in cellular response to ATP  
    involved_in cellular response to ATP  
    involved_in dendritic cell chemotaxis  
    involved_in dendritic cell chemotaxis  
    involved_in dendritic cell chemotaxis  
    involved_in inorganic cation transmembrane transport  
    involved_in inorganic cation transmembrane transport  
    involved_in long-term memory PubMed 
    involved_in membrane depolarization during AV node cell action potential  
    involved_in membrane depolarization during AV node cell action potential  
    involved_in membrane depolarization during Purkinje myocyte cell action potential  
    involved_in membrane depolarization during Purkinje myocyte cell action potential  
    involved_in membrane depolarization during bundle of His cell action potential  
    involved_in membrane depolarization during bundle of His cell action potential  
    involved_in metal ion transport  
    involved_in monoatomic cation transmembrane transport  
    involved_in monoatomic cation transmembrane transport  
    involved_in negative regulation of bone mineralization PubMed 
    involved_in negative regulation of osteoblast differentiation PubMed 
    involved_in positive regulation of adipose tissue development PubMed 
    involved_in positive regulation of atrial cardiac muscle cell action potential PubMed 
    involved_in positive regulation of canonical Wnt signaling pathway  
    involved_in positive regulation of canonical Wnt signaling pathway  
    involved_in positive regulation of canonical Wnt signaling pathway  
    involved_in positive regulation of cell population proliferation  
    involved_in positive regulation of cell population proliferation  
    involved_in positive regulation of cell population proliferation  
    involved_in positive regulation of cytosolic calcium ion concentration PubMed 
    involved_in positive regulation of fat cell differentiation PubMed 
    involved_in positive regulation of heart rate PubMed 
    involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus PubMed 
    involved_in positive regulation of regulation of vascular associated smooth muscle cell membrane depolarization PubMed 
    involved_in positive regulation of vasoconstriction PubMed 
    involved_in protein homotetramerization  
    involved_in protein homotetramerization  
    involved_in protein homotetramerization  
    involved_in protein sumoylation  
    involved_in protein sumoylation  
    involved_in protein sumoylation  
    involved_in regulation of T cell cytokine production  
    involved_in regulation of T cell cytokine production  
    involved_in regulation of T cell cytokine production  
    involved_in regulation of heart rate by cardiac conduction  
    involved_in regulation of heart rate by cardiac conduction  
    involved_in regulation of ventricular cardiac muscle cell action potential  
    involved_in regulation of ventricular cardiac muscle cell action potential  
    involved_in sodium ion import across plasma membrane  
    involved_in sodium ion import across plasma membrane  
    Items 1 - 25 of 53
    Component Evidence Code Pubs
    located_in Golgi apparatus PubMed 
    located_in Golgi apparatus  
    located_in Golgi apparatus  
    located_in endoplasmic reticulum PubMed 
    located_in endoplasmic reticulum  
    located_in endoplasmic reticulum  
    located_in membrane  
    located_in membrane  
    located_in neuronal cell body PubMed 
    located_in nucleoplasm  
    located_in nucleoplasm  
    is_active_in plasma membrane  
    located_in plasma membrane PubMed 
    located_in plasma membrane  
    located_in plasma membrane  
    located_in plasma membrane  
    part_of sodium channel complex  
    part_of sodium channel complex  

    General protein information

    Preferred Names
    transient receptor potential cation channel subfamily M member 4
    Names
    LTrpC4
    calcium-activated non-selective cation channel 1
    long transient receptor potential channel 4
    melastatin like 2 protein
    melastatin-like 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001136229.1NP_001129701.1  transient receptor potential cation channel subfamily M member 4

      See identical proteins and their annotated locations for NP_001129701.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/Swiss-Prot
      Q9ESQ5
      UniProtKB/TrEMBL
      A0A0H2UHX0
      Related
      ENSRNOP00000041387.4, ENSRNOT00000041513.6
      Conserved Domains (1) summary
      cl39032
      Location:91346
      LSDAT_euk; SLOG in TRPM

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      104918462..104949453 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039088263.2XP_038944191.1  transient receptor potential cation channel subfamily M member 4 isoform X1

      Conserved Domains (1) summary
      cl39032
      Location:179434
      LSDAT_euk; SLOG in TRPM

    RNA

    1. XR_001835352.3 RNA Sequence

    2. XR_005491008.2 RNA Sequence

    3. XR_005491011.2 RNA Sequence

    4. XR_005491016.2 RNA Sequence

    5. XR_005491013.2 RNA Sequence

    External link. Please review our privacy policy.