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    Agk acylglycerol kinase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 502749, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Agkprovided by RGD
    Official Full Name
    acylglycerol kinaseprovided by RGD
    Primary source
    RGD:1562046
    See related
    EnsemblRapid:ENSRNOG00000011509 AllianceGenome:RGD:1562046
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1562046
    Summary
    Predicted to enable acylglycerol kinase activity and lipid kinase activity. Predicted to be involved in ceramide biosynthetic process; protein insertion into mitochondrial inner membrane; and sphingosine biosynthetic process. Predicted to act upstream of or within lipid phosphorylation. Predicted to be located in mitochondrial inner membrane and mitochondrial intermembrane space. Predicted to be part of TIM22 mitochondrial import inner membrane insertion complex. Predicted to be active in membrane and mitochondrion. Human ortholog(s) of this gene implicated in Sengers syndrome and cataract 38. Orthologous to human AGK (acylglycerol kinase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 66.2), Thymus (RPKM 64.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Agk in Genome Data Viewer
    Location:
    4q23
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (70081550..70160642)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (69114850..69193989)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (68483345..68561518)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103692103 Neighboring gene transmembrane protein 178B Neighboring gene uncharacterized LOC102555151 Neighboring gene DENN domain containing 11 Neighboring gene WEE2 oocyte meiosis inhibiting kinase Neighboring gene single stranded DNA binding protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A novel acylglycerol kinase that produces lysophosphatidic acid modulates cross talk with EGFR in prostate cancer cells. Bektas M, et al. J Cell Biol, 2005 Jun 6. PMID 15939762, Free PMC Article
    2. MuLK, a eukaryotic multi-substrate lipid kinase. Waggoner DW, et al. J Biol Chem, 2004 Sep 10. PMID 15252046
    3. Expression of lysophosphatidic acid, autotaxin and acylglycerol kinase as biomarkers in diabetic retinopathy. Abu El-Asrar AM, et al. Acta Diabetol, 2013 Jun. PMID 22864860
    4. Sengers Syndrome-Associated Mitochondrial Acylglycerol Kinase Is a Subunit of the Human TIM22 Protein Import Complex. Kang Y, et al. Mol Cell, 2017 Aug 3. PMID 28712726
    5. Further characterization of mammalian ceramide kinase: substrate delivery and (stereo)specificity, tissue distribution, and subcellular localization studies. Van Overloop H, et al. J Lipid Res, 2006 Feb. PMID 16269826

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Our findings suggest that ATX-AGK-LPA signaling axis might be an important player in the development and progression of diabetic retinopathy.
      Title: Expression of lysophosphatidic acid, autotaxin and acylglycerol kinase as biomarkers in diabetic retinopathy.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP-dependent diacylglycerol kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP-dependent diacylglycerol kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables D-erythro-sphingosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables acylglycerol kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables acylglycerol kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ceramide kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ceramide kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables lipid kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in ceramide biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within ceramide biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glycerolipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within lipid phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein insertion into mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in sphingosine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of TIM22 mitochondrial import inner membrane insertion complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial intermembrane space ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    acylglycerol kinase, mitochondrial
    NP_001120969.1
    XP_008761043.1
    XP_017448334.1
    XP_017448335.1
    XP_038964167.1
    XP_038964168.1
    XP_038964169.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001127497.1 → NP_001120969.1  acylglycerol kinase, mitochondrial

      See identical proteins and their annotated locations for NP_001120969.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473959
      UniProtKB/TrEMBL
      A6IEW6, D3Z9L0
      Related
      ENSRNOP00000111857.1, ENSRNOT00000134748.1
      Conserved Domains (1) summary
      pfam00781
      Location:62 → 195
      DAGK_cat; Diacylglycerol kinase catalytic domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      70081550..70160642
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039108239.2 → XP_038964167.1  acylglycerol kinase, mitochondrial isoform X2

      Conserved Domains (1) summary
      pfam00781
      Location:62 → 195
      DAGK_cat; Diacylglycerol kinase catalytic domain

    2. XM_017592846.3 → XP_017448335.1  acylglycerol kinase, mitochondrial isoform X3

      Related
      ENSRNOP00000107145.1, ENSRNOT00000122767.1
      Conserved Domains (1) summary
      pfam00781
      Location:26 → 159
      DAGK_cat; Diacylglycerol kinase catalytic domain

    3. XM_017592845.3 → XP_017448334.1  acylglycerol kinase, mitochondrial isoform X1

      UniProtKB/TrEMBL
      A6IEW6, D3Z9L0
      Conserved Domains (1) summary
      pfam00781
      Location:62 → 195
      DAGK_cat; Diacylglycerol kinase catalytic domain

    4. XM_039108240.2 → XP_038964168.1  acylglycerol kinase, mitochondrial isoform X3

      Conserved Domains (1) summary
      pfam00781
      Location:26 → 159
      DAGK_cat; Diacylglycerol kinase catalytic domain

    5. XM_008762821.4 → XP_008761043.1  acylglycerol kinase, mitochondrial isoform X1

      See identical proteins and their annotated locations for XP_008761043.1

      UniProtKB/TrEMBL
      A6IEW6, D3Z9L0
      Related
      ENSRNOP00000108388.1, ENSRNOT00000137915.1
      Conserved Domains (1) summary
      pfam00781
      Location:62 → 195
      DAGK_cat; Diacylglycerol kinase catalytic domain

    6. XM_039108241.2 → XP_038964169.1  acylglycerol kinase, mitochondrial isoform X3

      Conserved Domains (1) summary
      pfam00781
      Location:26 → 159
      DAGK_cat; Diacylglycerol kinase catalytic domain
    Nucleotide Protein Strain
    Heading Accession and Version

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