Tp53bp1 tumor protein p53 binding protein 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tp53bp1provided by RGD
Official Full Name: tumor protein p53 binding protein 1provided by RGD
Primary source: RGD:1308039
See related: EnsemblRapid:ENSRNOG00000013837 AllianceGenome:RGD:1308039
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Trp53bp1
Summary: Predicted to enable several functions, including DNA binding activity; modification-dependent protein binding activity; and p53 binding activity. Involved in cellular response to X-ray. Predicted to be located in chromosome; cytoplasm; and nuclear body. Predicted to be part of DNA repair complex. Predicted to be active in nucleus and site of double-strand break. Orthologous to human TP53BP1 (tumor protein p53 binding protein 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 150.1), Adrenal (RPKM 87.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q35

Exon count:: 33

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (128620320..128724716, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (108166574..108270229, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (113160030..113259701, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH44505 (e-PCR)
- UniSTS:74295

AU049532 (e-PCR)
- UniSTS:145979

D3Rat259 (e-PCR), detects polymorphism
- UniSTS:227644

RH139947 (e-PCR)
- UniSTS:222030

RH68009 (e-PCR)
- UniSTS:18818

BI287966 (e-PCR)
- UniSTS:245912

BE108329 (e-PCR)
- UniSTS:247728

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables RNA polymerase II-specific DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables damaged DNA binding	ISO Inferred from Sequence Orthology more info
enables histone binding	IBA Inferred from Biological aspect of Ancestor more info
enables histone reader activity	ISO Inferred from Sequence Orthology more info
enables methylated histone binding	ISO Inferred from Sequence Orthology more info
enables p53 binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables telomeric DNA binding	ISO Inferred from Sequence Orthology more info
enables transcription coregulator activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin-modified histone reader activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in DNA damage checkpoint signaling	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within DNA damage response	ISO Inferred from Sequence Orthology more info
involved_in DNA damage response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within DNA repair	ISO Inferred from Sequence Orthology more info
involved_in cellular response to X-ray	IEP Inferred from Expression Pattern more info	PubMed
involved_in chromatin organization	IEA Inferred from Electronic Annotation more info
involved_in double-strand break repair via classical nonhomologous end joining	ISO Inferred from Sequence Orthology more info
involved_in double-strand break repair via nonhomologous end joining	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of double-strand break repair via homologous recombination	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of isotype switching	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in protein homooligomerization	ISO Inferred from Sequence Orthology more info
involved_in protein localization to site of double-strand break	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of DNA repair complex	ISO Inferred from Sequence Orthology more info
located_in chromosome, telomeric region	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in kinetochore	ISO Inferred from Sequence Orthology more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in replication fork	ISO Inferred from Sequence Orthology more info
is_active_in site of double-strand break	ISO Inferred from Sequence Orthology more info
located_in site of double-strand break	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: TP53-binding protein 1

Names: transformation related protein 53 binding protein 1; tumor suppressor p53-binding protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001371259.1 → NP_001358188.1 TP53-binding protein 1

Status: VALIDATED

Source sequence(s)

CK840114, JAXUCZ010000003

UniProtKB/TrEMBL

A0A8I6AB98, A0A8I6AKV2

Related

ENSRNOP00000093681.1, ENSRNOT00000107143.2

Conserved Domains (4) summary

TIGR03835
Location:705 → 992

termin_org_DnaJ; terminal organelle assembly protein TopJ

cd17745
Location:1688 → 1799

BRCT_p53bp1_rpt1; first (central) BRCT domain in p53-binding protein 1 (p53BP1) and similar proteins

pfam09038
Location:1444 → 1564

53-BP1_Tudor; tumor suppressor p53-binding protein-1 Tudor

pfam18428
Location:1827 → 1930

BRCT_3; BRCA1 C Terminus (BRCT) domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

128620320..128724716 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017592215.3 → XP_017447704.1 TP53-binding protein 1 isoform X1

UniProtKB/TrEMBL

A0A8I6AB98, F1M842

Conserved Domains (2) summary

smart00292
Location:1866 → 1951

BRCT; breast cancer carboxy-terminal domain

pfam09038
Location:1484 → 1604

53-BP1_Tudor; Tumour suppressor p53-binding protein-1 Tudor
XM_063283318.1 → XP_063139388.1 TP53-binding protein 1 isoform X1

UniProtKB/TrEMBL

A0A8I6AB98, F1M842
XM_006234865.5 → XP_006234927.1 TP53-binding protein 1 isoform X1

See identical proteins and their annotated locations for XP_006234927.1

UniProtKB/TrEMBL

A0A8I6AB98, F1M842

Conserved Domains (2) summary

smart00292
Location:1866 → 1951

BRCT; breast cancer carboxy-terminal domain

pfam09038
Location:1484 → 1604

53-BP1_Tudor; Tumour suppressor p53-binding protein-1 Tudor
XM_063283319.1 → XP_063139389.1 TP53-binding protein 1 isoform X2

UniProtKB/TrEMBL

A0A8I6AB98, A0A8I6AKV2
XM_063283321.1 → XP_063139391.1 TP53-binding protein 1 isoform X4

UniProtKB/TrEMBL

A0A8I6AB98

Related

ENSRNOP00000105803.1, ENSRNOT00000141208.1
XM_063283320.1 → XP_063139390.1 TP53-binding protein 1 isoform X3

UniProtKB/TrEMBL

A0A8I6AB98

Related

ENSRNOP00000104581.1, ENSRNOT00000128902.1
XM_017592214.3 → XP_017447703.1 TP53-binding protein 1 isoform X1

UniProtKB/TrEMBL

A0A8I6AB98, F1M842

Related

ENSRNOP00000019025.7, ENSRNOT00000019025.10

Conserved Domains (2) summary

smart00292
Location:1866 → 1951

BRCT; breast cancer carboxy-terminal domain

pfam09038
Location:1484 → 1604

53-BP1_Tudor; Tumour suppressor p53-binding protein-1 Tudor
XM_039104554.2 → XP_038960482.1 TP53-binding protein 1 isoform X5

UniProtKB/TrEMBL

A6HPN0

Conserved Domains (3) summary

cd17745
Location:774 → 885

BRCT_p53bp1_rpt1; first (central) BRCT domain in p53-binding protein 1 (p53BP1) and similar proteins

pfam09038
Location:530 → 650

53-BP1_Tudor; tumor suppressor p53-binding protein-1 Tudor

pfam18428
Location:913 → 1016

BRCT_3; BRCA1 C Terminus (BRCT) domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001106501.1: Suppressed sequence

Description

NM_001106501.1: This RefSeq was suppressed temporarily based on the calculation that the encoded protein was shorter than proteins from the putative ortholog from human: TP53BP1 (GeneID:7158).