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    Yaf2 YY1 associated factor 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 690262, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Yaf2provided by RGD
    Official Full Name
    YY1 associated factor 2provided by RGD
    Primary source
    RGD:1582851
    See related
    AllianceGenome:RGD:1582851
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable DNA binding activity; transcription coactivator activity; and transcription corepressor activity. Predicted to be involved in negative regulation of DNA-templated transcription and positive regulation of DNA-templated transcription. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in nucleus. Orthologous to human YAF2 (YY1 associated factor 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 171.7), Heart (RPKM 125.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Yaf2 in Genome Data Viewer
    Location:
    7q35
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (126323604..126379061, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (124444152..124499688, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (134505352..134560713, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102552792 Neighboring gene uncharacterized LOC134479777 Neighboring gene glucoside xylosyltransferase 1 Neighboring gene 60S ribosomal protein L30 pseudogene Neighboring gene uncharacterized LOC134479778 Neighboring gene uncharacterized LOC108351532 Neighboring gene zinc finger CCHC-type and RNA binding motif containing 1 Neighboring gene periphilin 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Salidroside alleviates severe acute pancreatitis-triggered pancreatic injury and inflammation by regulating miR-217-5p/YAF2 axis. Wang X, et al. Int Immunopharmacol, 2022 Oct. PMID 35963157
    2. Functional interaction of Yaf2 with the central region of MycN. Bannasch D, et al. Oncogene, 2001 Sep 13. PMID 11593398
    3. Yaf2 inhibits Myc biological function. Mädge B, et al. Cancer Lett, 2003 Apr 25. PMID 12706874
    4. The mouse YAF2 gene generates two distinct transcripts and is expressed in pre-and postimplantation embryos. Kaneko T, et al. Gene, 2003 Oct 2. PMID 14557078
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Salidroside alleviates severe acute pancreatitis-triggered pancreatic injury and inflammation by regulating miR-217-5p/YAF2 axis.
      Title: Salidroside alleviates severe acute pancreatitis-triggered pancreatic injury and inflammation by regulating miR-217-5p/YAF2 axis.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription coregulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription corepressor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    YY1-associated factor 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001134871.2 → NP_001128343.1  YY1-associated factor 2

      See identical proteins and their annotated locations for NP_001128343.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000007
      UniProtKB/TrEMBL
      A6K7S7, A6K7S8
      Conserved Domains (3) summary
      sd00029
      Location:23 → 42
      zf-RanBP2; RanBP2-type Zn finger [structural motif]
      pfam00641
      Location:20 → 43
      zf-RanBP; Zn-finger in Ran binding protein and others
      pfam17219
      Location:102 → 133
      YAF2_RYBP; Yaf2/RYBP C-terminal binding motif

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      126323604..126379061 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063264282.1 → XP_063120352.1  YY1-associated factor 2 isoform X3

      UniProtKB/TrEMBL
      A6K7S7

    2. XM_039079923.2 → XP_038935851.1  YY1-associated factor 2 isoform X2

      Conserved Domains (1) summary
      pfam17219
      Location:57 → 88
      YAF2_RYBP; Yaf2/RYBP C-terminal binding motif

    3. XM_063264281.1 → XP_063120351.1  YY1-associated factor 2 isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
    Research Materials
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