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    Pfn2 profilin 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 81531, updated on 9-Dec-2024

    Summary

    Symbol
    Pfn2provided by RGD
    Full Name
    profilin 2provided by RGD
    Primary source
    RGD:621826
    See related
    EnsemblRapid:ENSRNOG00000017427 AllianceGenome:RGD:621826
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables actin binding activity. Involved in regulation of actin filament polymerization. Predicted to be located in cytoskeleton. Predicted to be active in several cellular components, including Schaffer collateral - CA1 synapse; glutamatergic synapse; and postsynapse. Orthologous to human PFN2 (profilin 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 581.7), Muscle (RPKM 203.8) and 8 other tissues See more
    Orthologs
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    Genomic context

    See Pfn2 in Genome Data Viewer
    Location:
    2q26
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (144217100..144222936, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (142067102..142072938, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (147953858..147959692, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein L12, pseudogene 2 Neighboring gene ring finger protein 13 Neighboring gene transfer RNA proline (anticodon AGG) 40 Neighboring gene 60S ribosomal protein L34 pseudogene Neighboring gene uncharacterized LOC120100826 Neighboring gene non-POU domain containing, octamer-binding, pseudogene 2 Neighboring gene uncharacterized LOC120100828

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Interactions

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP hydrolysis activity  
    enables ATP hydrolysis activity  
    enables actin binding  
    enables actin binding PubMed 
    enables actin monomer binding  
    enables actin monomer binding  
    enables phosphatidylinositol-4,5-bisphosphate binding  
    enables phosphatidylinositol-4,5-bisphosphate binding  
    Items 1 - 25 of 28
    Process Evidence Code Pubs
    involved_in modification of postsynaptic actin cytoskeleton  
    involved_in modification of postsynaptic actin cytoskeleton  
    involved_in modulation of chemical synaptic transmission  
    involved_in negative regulation of actin filament polymerization  
    involved_in negative regulation of actin filament polymerization  
    involved_in negative regulation of epithelial cell migration  
    involved_in negative regulation of epithelial cell migration  
    involved_in negative regulation of ruffle assembly  
    involved_in negative regulation of ruffle assembly  
    involved_in positive regulation of ATP-dependent activity  
    involved_in positive regulation of actin filament bundle assembly  
    involved_in positive regulation of actin filament bundle assembly  
    involved_in positive regulation of actin filament polymerization  
    acts_upstream_of_or_within positive regulation of actin filament polymerization  
    involved_in positive regulation of actin filament polymerization  
    involved_in positive regulation of peptidyl-serine phosphorylation  
    involved_in positive regulation of stress fiber assembly  
    involved_in positive regulation of stress fiber assembly  
    involved_in presynaptic actin cytoskeleton organization  
    involved_in presynaptic actin cytoskeleton organization  
    involved_in presynaptic modulation of chemical synaptic transmission  
    involved_in presynaptic modulation of chemical synaptic transmission  
    involved_in protein stabilization  
    involved_in protein stabilization  
    involved_in regulation of actin filament polymerization  
    involved_in regulation of actin filament polymerization PubMed 
    involved_in regulation of synaptic vesicle exocytosis  
    acts_upstream_of_or_within regulation of synaptic vesicle exocytosis  
    Items 1 - 25 of 28
    Component Evidence Code Pubs
    located_in Schaffer collateral - CA1 synapse  
    is_active_in Schaffer collateral - CA1 synapse  
    is_active_in cytoplasm  
    located_in cytoskeleton  
    located_in glutamatergic synapse  
    is_active_in glutamatergic synapse  
    located_in postsynapse  
    is_active_in postsynapse  
    located_in presynapse  
    is_active_in presynapse  

    General protein information

    Preferred Names
    profilin-2
    Names
    profilin II
    profilin-2-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_030873.2NP_110500.2  profilin-2

      Status: VALIDATED

      Source sequence(s)
      FM077173, JAXUCZ010000002
      UniProtKB/Swiss-Prot
      Q9EPC6, Q9JHU7
      UniProtKB/TrEMBL
      A6JVH9, D3ZDU5, D4A9A4
      Related
      ENSRNOP00000023469.3, ENSRNOT00000023469.9
      Conserved Domains (1) summary
      smart00392
      Location:2140
      PROF; Profilin

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      144217100..144222936 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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