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    Hivep1 HIVEP zinc finger 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 117140, updated on 27-Dec-2024

    Summary

    Official Symbol
    Hivep1provided by RGD
    Official Full Name
    HIVEP zinc finger 1provided by RGD
    Primary source
    RGD:727847
    See related
    EnsemblRapid:ENSRNOG00000014460 AllianceGenome:RGD:727847
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables DNA binding activity. Predicted to be involved in BMP signaling pathway; negative regulation of transcription by RNA polymerase II; and positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within negative regulation of DNA-templated transcription. Predicted to be located in cytosol; mitochondrion; and nuclear body. Predicted to be active in nucleus. Orthologous to human HIVEP1 (HIVEP zinc finger 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 81.1), Lung (RPKM 63.0) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Hivep1 in Genome Data Viewer
    Location:
    17p12
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (22790855..22920359, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (22585016..22714517, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (22278103..22403362, complement)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene endothelin 1 Neighboring gene uncharacterized LOC102548003 Neighboring gene uncharacterized LOC120097876 Neighboring gene uncharacterized LOC108348545 Neighboring gene uncharacterized LOC134482771 Neighboring gene uncharacterized LOC134482838

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding PubMed 
    enables DNA binding  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific  
    enables HMG box domain binding  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding  
    enables metal ion binding  
    enables sequence-specific double-stranded DNA binding  
    Component Evidence Code Pubs
    located_in cytosol  
    located_in cytosol  
    located_in mitochondrion  
    located_in mitochondrion  
    located_in nuclear body  
    located_in nuclear body  
    located_in nucleoplasm  
    is_active_in nucleus  
    located_in nucleus  

    General protein information

    Preferred Names
    zinc finger protein 40
    Names
    human immunodeficiency virus type I enhancer binding protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001105751.2NP_001099221.2  zinc finger protein 40

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000017
      UniProtKB/TrEMBL
      A6J757
      Conserved Domains (4) summary
      smart00355
      Location:21002121
      ZnF_C2H2; zinc finger
      PHA03247
      Location:22722662
      PHA03247; large tegument protein UL36; Provisional
      sd00017
      Location:409429
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:20742094
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      22790855..22920359 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039095309.2XP_038951237.1  zinc finger protein 40 isoform X1

      UniProtKB/TrEMBL
      A6J757
      Conserved Domains (6) summary
      PHA03247
      Location:22732663
      PHA03247; large tegument protein UL36; Provisional
      sd00017
      Location:409429
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:20752095
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:20732095
      zf-C2H2; Zinc finger, C2H2 type
      pfam12756
      Location:21012166
      zf-C2H2_2; C2H2 type zinc-finger (2 copies)
      pfam13465
      Location:422446
      zf-H2C2_2; Zinc-finger double domain
    2. XM_039095308.1XP_038951236.1  zinc finger protein 40 isoform X1

      UniProtKB/TrEMBL
      A6J757
      Conserved Domains (6) summary
      PHA03247
      Location:22732663
      PHA03247; large tegument protein UL36; Provisional
      sd00017
      Location:409429
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:20752095
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:20732095
      zf-C2H2; Zinc finger, C2H2 type
      pfam12756
      Location:21012166
      zf-C2H2_2; C2H2 type zinc-finger (2 copies)
      pfam13465
      Location:422446
      zf-H2C2_2; Zinc-finger double domain
    3. XM_039095310.1XP_038951238.1  zinc finger protein 40 isoform X1

      UniProtKB/TrEMBL
      A6J757
      Related
      ENSRNOP00000019389.8, ENSRNOT00000019389.9
      Conserved Domains (6) summary
      PHA03247
      Location:22732663
      PHA03247; large tegument protein UL36; Provisional
      sd00017
      Location:409429
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:20752095
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:20732095
      zf-C2H2; Zinc finger, C2H2 type
      pfam12756
      Location:21012166
      zf-C2H2_2; C2H2 type zinc-finger (2 copies)
      pfam13465
      Location:422446
      zf-H2C2_2; Zinc-finger double domain
    4. XM_063276029.1XP_063132099.1  zinc finger protein 40 isoform X2

      UniProtKB/TrEMBL
      A6J757, F1M9H4
    5. XM_063276031.1XP_063132101.1  zinc finger protein 40 isoform X4

    6. XM_063276030.1XP_063132100.1  zinc finger protein 40 isoform X3

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