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    RHOT2 ras homolog family member T2 [ Homo sapiens (human) ]

    Gene ID: 89941, updated on 5-Jan-2025

    Summary

    Official Symbol
    RHOT2provided by HGNC
    Official Full Name
    ras homolog family member T2provided by HGNC
    Primary source
    HGNC:HGNC:21169
    See related
    Ensembl:ENSG00000140983 MIM:613889; AllianceGenome:HGNC:21169
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RASL; ARHT2; MIRO2; MIRO-2; C16orf39
    Summary
    This gene encodes a member of the Rho family of GTPases. The encoded protein is localized to the outer mitochondrial membrane and plays a role in mitochondrial trafficking and fusion-fission dynamics. [provided by RefSeq, Nov 2011]
    Expression
    Ubiquitous expression in spleen (RPKM 20.5), duodenum (RPKM 16.0) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See RHOT2 in Genome Data Viewer
    Location:
    16p13.3
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (668083..674174)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (672158..678249)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (718083..724174)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:690840-691751 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6931 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6932 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10209 Neighboring gene MAPK regulated corepressor interacting protein 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10210 Neighboring gene uncharacterized LOC105371038 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:699402-700224 Neighboring gene WD repeat domain 90 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:709386-710276 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:717843-718524 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6937 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:724963-725497 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6938 Neighboring gene rhomboid like 1 Neighboring gene STUB1 divergent transcript

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    BioGRID CRISPR Screen Phenotypes (53 hits/1279 screens)

    EBI GWAS Catalog

    Description
    Genome-wide association analysis of red blood cell traits in African Americans: the COGENT Network.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables GTP binding  
    enables GTPase activity  
    enables calcium ion binding  
    enables protein binding PubMed 

    General protein information

    Preferred Names
    mitochondrial Rho GTPase 2
    Names
    mitochondrial Rho (MIRO) GTPase 2
    ras homolog gene family, member T2
    NP_001339204.1
    NP_001339205.1
    NP_001339206.1
    NP_001339207.1
    NP_001339208.1
    NP_001339209.1
    NP_001339210.1
    NP_001339211.1
    NP_001339212.1
    NP_001339213.1
    NP_001339214.1
    NP_001339215.1
    NP_001339216.1
    NP_001339217.1
    NP_001339218.1
    NP_001339219.1
    NP_001339220.1
    NP_001339221.1
    NP_001339222.1
    NP_001339223.1
    NP_620124.1
    XP_047290796.1
    XP_047290797.1
    XP_047290798.1
    XP_047290799.1
    XP_047290800.1
    XP_047290801.1
    XP_047290802.1
    XP_047290803.1
    XP_047290804.1
    XP_054170254.1
    XP_054170255.1
    XP_054170256.1
    XP_054170257.1
    XP_054170258.1
    XP_054170259.1
    XP_054170260.1
    XP_054170261.1
    XP_054170262.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_031824.1 RefSeqGene

      Range
      5050..11089
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001352275.2 → NP_001339204.1  mitochondrial Rho GTPase 2 isoform 1

      Status: REVIEWED

      Source sequence(s)
      Z92544
      Consensus CDS
      CCDS92073.1
      UniProtKB/TrEMBL
      A0A8V8TM48
      Related
      ENSP00000513180.1, ENST00000697194.1
      Conserved Domains (4) summary
      cd01892
      Location:414 → 590
      Miro2; Mitochondrial Rho family 2 (Miro2), C-terminal
      cd01893
      Location:3 → 169
      Miro1; Mitochondrial Rho family 1 (Miro1), N-terminal
      pfam08355
      Location:342 → 408
      EF_assoc_1; EF hand associated
      pfam08356
      Location:221 → 306
      EF_assoc_2; EF hand associated
    2. NM_001352276.2 → NP_001339205.1  mitochondrial Rho GTPase 2 isoform 3

      Status: REVIEWED

      Source sequence(s)
      Z92544
      Conserved Domains (4) summary
      cd01892
      Location:396 → 572
      Miro2; Mitochondrial Rho family 2 (Miro2), C-terminal
      cd01893
      Location:3 → 151
      Miro1; Mitochondrial Rho family 1 (Miro1), N-terminal
      pfam08355
      Location:324 → 390
      EF_assoc_1; EF hand associated
      pfam08356
      Location:203 → 288
      EF_assoc_2; EF hand associated
    3. NM_001352277.2 → NP_001339206.1  mitochondrial Rho GTPase 2 isoform 4

      Status: REVIEWED

      Source sequence(s)
      Z92544
      Conserved Domains (4) summary
      cd01892
      Location:395 → 571
      Miro2; Mitochondrial Rho family 2 (Miro2), C-terminal
      cd01893
      Location:3 → 151
      Miro1; Mitochondrial Rho family 1 (Miro1), N-terminal
      pfam08355
      Location:323 → 389
      EF_assoc_1; EF hand associated
      pfam08356
      Location:202 → 287
      EF_assoc_2; EF hand associated
    4. NM_001352278.2 → NP_001339207.1  mitochondrial Rho GTPase 2 isoform 5

      Status: REVIEWED

      Source sequence(s)
      Z92544
      Conserved Domains (4) summary
      cd01892
      Location:380 → 556
      Miro2; Mitochondrial Rho family 2 (Miro2), C-terminal
      cd01893
      Location:3 → 169
      Miro1; Mitochondrial Rho family 1 (Miro1), N-terminal
      pfam08355
      Location:308 → 374
      EF_assoc_1; EF hand associated
      pfam08356
      Location:187 → 272
      EF_assoc_2; EF hand associated
    5. NM_001352279.2 → NP_001339208.1  mitochondrial Rho GTPase 2 isoform 6

      Status: REVIEWED

      Source sequence(s)
      Z92544
      Conserved Domains (4) summary
      cd01892
      Location:362 → 538
      Miro2; Mitochondrial Rho family 2 (Miro2), C-terminal
      cd01893
      Location:3 → 151
      Miro1; Mitochondrial Rho family 1 (Miro1), N-terminal
      pfam08355
      Location:290 → 356
      EF_assoc_1; EF hand associated
      pfam08356
      Location:169 → 254
      EF_assoc_2; EF hand associated
    6. NM_001352280.2 → NP_001339209.1  mitochondrial Rho GTPase 2 isoform 7

      Status: REVIEWED

      Source sequence(s)
      Z92544
      Conserved Domains (4) summary
      cd01892
      Location:307 → 483
      Miro2; Mitochondrial Rho family 2 (Miro2), C-terminal
      pfam08355
      Location:235 → 301
      EF_assoc_1; EF hand associated
      pfam08356
      Location:114 → 199
      EF_assoc_2; EF hand associated
      cl21455
      Location:9 → 62
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    7. NM_001352281.2 → NP_001339210.1  mitochondrial Rho GTPase 2 isoform 8

      Status: REVIEWED

      Source sequence(s)
      Z92544
      Related
      ENST00000569675.5
      Conserved Domains (4) summary
      cd01892
      Location:306 → 482
      Miro2; Mitochondrial Rho family 2 (Miro2), C-terminal
      pfam08355
      Location:234 → 301
      EF_assoc_1; EF hand associated
      pfam08356
      Location:113 → 196
      EF_assoc_2; EF hand associated
      cl38936
      Location:9 → 62
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    8. NM_001352282.2 → NP_001339211.1  mitochondrial Rho GTPase 2 isoform 8

      Status: REVIEWED

      Source sequence(s)
      Z92544
      Conserved Domains (4) summary
      cd01892
      Location:306 → 482
      Miro2; Mitochondrial Rho family 2 (Miro2), C-terminal
      pfam08355
      Location:234 → 301
      EF_assoc_1; EF hand associated
      pfam08356
      Location:113 → 196
      EF_assoc_2; EF hand associated
      cl38936
      Location:9 → 62
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    9. NM_001352283.2 → NP_001339212.1  mitochondrial Rho GTPase 2 isoform 9

      Status: REVIEWED

      Source sequence(s)
      Z92544
      Conserved Domains (4) summary
      cd01892
      Location:286 → 462
      Miro2; Mitochondrial Rho family 2 (Miro2), C-terminal
      pfam08355
      Location:214 → 280
      EF_assoc_1; EF hand associated
      pfam08356
      Location:93 → 178
      EF_assoc_2; EF hand associated
      cl21455
      Location:1 → 42
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    10. NM_001352284.2 → NP_001339213.1  mitochondrial Rho GTPase 2 isoform 10

      Status: REVIEWED

      Source sequence(s)
      Z92544
      Conserved Domains (4) summary
      cd01892
      Location:274 → 450
      Miro2; Mitochondrial Rho family 2 (Miro2), C-terminal
      pfam08355
      Location:202 → 268
      EF_assoc_1; EF hand associated
      pfam08356
      Location:81 → 166
      EF_assoc_2; EF hand associated
      cl21455
      Location:9 → 62
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    11. NM_001352285.2 → NP_001339214.1  mitochondrial Rho GTPase 2 isoform 11

      Status: REVIEWED

      Source sequence(s)
      Z92544
      Conserved Domains (4) summary
      cd01892
      Location:273 → 449
      Miro2; Mitochondrial Rho family 2 (Miro2), C-terminal
      pfam08355
      Location:201 → 267
      EF_assoc_1; EF hand associated
      pfam08356
      Location:80 → 165
      EF_assoc_2; EF hand associated
      cl21455
      Location:9 → 62
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    12. NM_001352286.2 → NP_001339215.1  mitochondrial Rho GTPase 2 isoform 12

      Status: REVIEWED

      Source sequence(s)
      Z92544
      Conserved Domains (4) summary
      cd01892
      Location:254 → 430
      Miro2; Mitochondrial Rho family 2 (Miro2), C-terminal
      pfam08355
      Location:182 → 248
      EF_assoc_1; EF hand associated
      pfam08356
      Location:61 → 146
      EF_assoc_2; EF hand associated
      cl21455
      Location:1 → 42
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    13. NM_001352287.1 → NP_001339216.1  mitochondrial Rho GTPase 2 isoform 13

      Status: REVIEWED

      Source sequence(s)
      AL834163, Z92544
      Conserved Domains (3) summary
      cd01892
      Location:192 → 368
      Miro2; Mitochondrial Rho family 2 (Miro2), C-terminal
      pfam08355
      Location:120 → 186
      EF_assoc_1; EF hand associated
      pfam08356
      Location:28 → 84
      EF_assoc_2; EF hand associated
    14. NM_001352288.2 → NP_001339217.1  mitochondrial Rho GTPase 2 isoform 13

      Status: REVIEWED

      Source sequence(s)
      Z92544
      Conserved Domains (3) summary
      cd01892
      Location:192 → 368
      Miro2; Mitochondrial Rho family 2 (Miro2), C-terminal
      pfam08355
      Location:120 → 186
      EF_assoc_1; EF hand associated
      pfam08356
      Location:28 → 84
      EF_assoc_2; EF hand associated
    15. NM_001352289.2 → NP_001339218.1  mitochondrial Rho GTPase 2 isoform 13

      Status: REVIEWED

      Source sequence(s)
      Z92544
      Conserved Domains (3) summary
      cd01892
      Location:192 → 368
      Miro2; Mitochondrial Rho family 2 (Miro2), C-terminal
      pfam08355
      Location:120 → 186
      EF_assoc_1; EF hand associated
      pfam08356
      Location:28 → 84
      EF_assoc_2; EF hand associated
    16. NM_001352290.2 → NP_001339219.1  mitochondrial Rho GTPase 2 isoform 13

      Status: REVIEWED

      Source sequence(s)
      Z92544
      Conserved Domains (3) summary
      cd01892
      Location:192 → 368
      Miro2; Mitochondrial Rho family 2 (Miro2), C-terminal
      pfam08355
      Location:120 → 186
      EF_assoc_1; EF hand associated
      pfam08356
      Location:28 → 84
      EF_assoc_2; EF hand associated
    17. NM_001352291.2 → NP_001339220.1  mitochondrial Rho GTPase 2 isoform 13

      Status: REVIEWED

      Source sequence(s)
      Z92544
      Conserved Domains (3) summary
      cd01892
      Location:192 → 368
      Miro2; Mitochondrial Rho family 2 (Miro2), C-terminal
      pfam08355
      Location:120 → 186
      EF_assoc_1; EF hand associated
      pfam08356
      Location:28 → 84
      EF_assoc_2; EF hand associated
    18. NM_001352292.2 → NP_001339221.1  mitochondrial Rho GTPase 2 isoform 13

      Status: REVIEWED

      Source sequence(s)
      Z92544
      Conserved Domains (3) summary
      cd01892
      Location:192 → 368
      Miro2; Mitochondrial Rho family 2 (Miro2), C-terminal
      pfam08355
      Location:120 → 186
      EF_assoc_1; EF hand associated
      pfam08356
      Location:28 → 84
      EF_assoc_2; EF hand associated
    19. NM_001352293.2 → NP_001339222.1  mitochondrial Rho GTPase 2 isoform 13

      Status: REVIEWED

      Source sequence(s)
      Z92544
      Conserved Domains (3) summary
      cd01892
      Location:192 → 368
      Miro2; Mitochondrial Rho family 2 (Miro2), C-terminal
      pfam08355
      Location:120 → 186
      EF_assoc_1; EF hand associated
      pfam08356
      Location:28 → 84
      EF_assoc_2; EF hand associated
    20. NM_001352294.2 → NP_001339223.1  mitochondrial Rho GTPase 2 isoform 13

      Status: REVIEWED

      Source sequence(s)
      Z92544
      Conserved Domains (3) summary
      cd01892
      Location:192 → 368
      Miro2; Mitochondrial Rho family 2 (Miro2), C-terminal
      pfam08355
      Location:120 → 186
      EF_assoc_1; EF hand associated
      pfam08356
      Location:28 → 84
      EF_assoc_2; EF hand associated
    21. NM_138769.3 → NP_620124.1  mitochondrial Rho GTPase 2 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AJ517413, AL834163, AY207375, DB465261
      Consensus CDS
      CCDS10417.1
      UniProtKB/Swiss-Prot
      A2IDC2, Q8IXI1, Q8NF53, Q96C13, Q96S17, Q9BT60, Q9H7M8
      Related
      ENSP00000321971.4, ENST00000315082.9
      Conserved Domains (4) summary
      cd01892
      Location:413 → 589
      Miro2; Mitochondrial Rho family 2 (Miro2), C-terminal
      cd01893
      Location:3 → 169
      Miro1; Mitochondrial Rho family 1 (Miro1), N-terminal
      pfam08355
      Location:341 → 407
      EF_assoc_1; EF hand associated
      pfam08356
      Location:220 → 305
      EF_assoc_2; EF hand associated

    RNA

    1. NR_147953.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      Z92544
    2. NR_147954.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      Z92544
    3. NR_147955.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      Z92544
    4. NR_147956.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      Z92544

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      668083..674174
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047434843.1 → XP_047290799.1  mitochondrial Rho GTPase 2 isoform X2

    2. XM_047434844.1 → XP_047290800.1  mitochondrial Rho GTPase 2 isoform X2

    3. XM_047434845.1 → XP_047290801.1  mitochondrial Rho GTPase 2 isoform X3

    4. XM_047434848.1 → XP_047290804.1  mitochondrial Rho GTPase 2 isoform X5

    5. XM_047434846.1 → XP_047290802.1  mitochondrial Rho GTPase 2 isoform X3

    6. XM_047434842.1 → XP_047290798.1  mitochondrial Rho GTPase 2 isoform X2

    7. XM_047434847.1 → XP_047290803.1  mitochondrial Rho GTPase 2 isoform X4

    8. XM_047434841.1 → XP_047290797.1  mitochondrial Rho GTPase 2 isoform X1

    9. XM_047434840.1 → XP_047290796.1  mitochondrial Rho GTPase 2 isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      672158..678249
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054314282.1 → XP_054170257.1  mitochondrial Rho GTPase 2 isoform X2

    2. XM_054314283.1 → XP_054170258.1  mitochondrial Rho GTPase 2 isoform X2

    3. XM_054314284.1 → XP_054170259.1  mitochondrial Rho GTPase 2 isoform X3

    4. XM_054314287.1 → XP_054170262.1  mitochondrial Rho GTPase 2 isoform X5

    5. XM_054314285.1 → XP_054170260.1  mitochondrial Rho GTPase 2 isoform X3

    6. XM_054314281.1 → XP_054170256.1  mitochondrial Rho GTPase 2 isoform X2

    7. XM_054314286.1 → XP_054170261.1  mitochondrial Rho GTPase 2 isoform X4

    8. XM_054314280.1 → XP_054170255.1  mitochondrial Rho GTPase 2 isoform X1

    9. XM_054314279.1 → XP_054170254.1  mitochondrial Rho GTPase 2 isoform X1

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