Psmb8 proteasome 20S subunit beta 8 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Psmb8provided by RGD
Full Name: proteasome 20S subunit beta 8provided by RGD
Primary source: RGD:3426
See related: EnsemblRapid:ENSRNOG00000000456 AllianceGenome:RGD:3426
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Lmp7; Ring10
Summary: Predicted to enable endopeptidase activity. Predicted to be involved in fat cell differentiation; proteasome-mediated ubiquitin-dependent protein catabolic process; and regulation of endopeptidase activity. Predicted to act upstream of or within antigen processing and presentation. Predicted to be located in cytoplasm. Predicted to be part of proteasome core complex, beta-subunit complex and spermatoproteasome complex. Predicted to be active in cytosol and nucleus. Human ortholog(s) of this gene implicated in proteasome-associated autoinflammatory syndrome 1. Orthologous to human PSMB8 (proteasome 20S subunit beta 8). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 761.5), Spleen (RPKM 502.4) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 20p12

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	20	NC_086038.1 (4654068..4657049, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	20	NC_051355.1 (4652159..4655122, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	20	NC_005119.4 (3990809..3993772)

Chromosome 20 - NC_086038.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The inducible beta5i proteasome subunit contributes to proinsulin degradation in GRP94-deficient beta-cells and is overexpressed in type 2 diabetes pancreatic islets.
Title: The inducible β5i proteasome subunit contributes to proinsulin degradation in GRP94-deficient β-cells and is overexpressed in type 2 diabetes pancreatic islets.
LMP7 and LMP2 were detected in thymic epithelial and dendritic cells, in CD68 positive cells (macrophages, monocytes), and in CD90 lymphocytes through pre- and postnatal ontogenesis.
Title: Ontogenesis of rat immune system: Proteasome expression in different cell populations of the developing thymus.
LMP7 mRNA expression and protein content was reduced in alcoholic liver disease.
Title: [An experimental study on the relationship between proteasome LMP7 subunit and alcoholic liver disease].
LMP7 immuno-subunit is induced in renal cells exposed to a long-lasting renal ischemia and inflammation.
Title: Immuno-proteasome subunit LMP7 is up-regulated in the ischemic kidney in an experimental model of renovascular hypertension.

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General gene information

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Markers

RH139868 (e-PCR)
- UniSTS:221952

RH139398 (e-PCR)
- UniSTS:221484

D1S3697 (e-PCR)
- UniSTS:474275

RH132773 (e-PCR)
- UniSTS:216056

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables threonine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in antigen processing and presentation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within antigen processing and presentation	ISO Inferred from Sequence Orthology more info
involved_in antigen processing and presentation	NAS Non-traceable Author Statement more info	PubMed
involved_in fat cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in fat cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in fat cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteolysis involved in protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in regulation of endopeptidase activity	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
part_of proteasome complex	ISO Inferred from Sequence Orthology more info
part_of proteasome core complex	IEA Inferred from Electronic Annotation more info
part_of proteasome core complex	ISO Inferred from Sequence Orthology more info
part_of proteasome core complex	ISS Inferred from Sequence or Structural Similarity more info
part_of proteasome core complex	TAS Traceable Author Statement more info	PubMed
part_of proteasome core complex, beta-subunit complex	IBA Inferred from Biological aspect of Ancestor more info
part_of proteasome core complex, beta-subunit complex	ISS Inferred from Sequence or Structural Similarity more info
part_of spermatoproteasome complex	IEA Inferred from Electronic Annotation more info
part_of spermatoproteasome complex	ISO Inferred from Sequence Orthology more info
part_of spermatoproteasome complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: proteasome subunit beta type-8

Names: large multifunctional protease 7; low molecular mass polypeptide 7; macropain subunit C13; multicatalytic endopeptidase complex subunit C13; proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7); proteasome (prosome, macropain) subunit, beta type, 8; proteasome component C13; proteasome subunit beta 8; proteasome subunit beta type-8-like; proteasome subunit beta-5i

NP_542945.2

EC 3.4.25.1

XP_063135031.1

EC 3.4.25.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_080767.2 → NP_542945.2 proteasome subunit beta type-8

See identical proteins and their annotated locations for NP_542945.2

Status: VALIDATED

Source sequence(s)

BX883043

UniProtKB/Swiss-Prot

P28064, Q6MGA4

UniProtKB/TrEMBL

A0A023IKD2, A0A023IM45, A0A023IMI6

Related

ENSRNOP00000000528.5, ENSRNOT00000000528.8

Conserved Domains (2) summary

PTZ00488
Location:40 → 271

PTZ00488; Proteasome subunit beta type-5; Provisional

cd03761
Location:73 → 260

proteasome_beta_type_5; proteasome beta type-5 subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that ...