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    Gng7 G protein subunit gamma 7 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 58979, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gng7provided by RGD
    Official Full Name
    G protein subunit gamma 7provided by RGD
    Primary source
    RGD:61860
    See related
    EnsemblRapid:ENSRNOG00000019857 AllianceGenome:RGD:61860
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Hg3b
    Summary
    Predicted to enable G-protein beta-subunit binding activity. Predicted to be involved in G protein-coupled receptor signaling pathway and regulation of adenylate cyclase activity. Predicted to act upstream of or within behavioral fear response; locomotory behavior; and receptor guanylyl cyclase signaling pathway. Is active in Schaffer collateral - CA1 synapse; parallel fiber to Purkinje cell synapse; and synaptic vesicle membrane. Orthologous to human GNG7 (G protein subunit gamma 7). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Brain (RPKM 84.4) and Kidney (RPKM 12.3) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Gng7 in Genome Data Viewer
    Location:
    7q11
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (9348148..9411924)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (8697458..8761239)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (11565740..11629519)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120093772 Neighboring gene DIRAS family GTPase 1 Neighboring gene uncharacterized LOC102553301 Neighboring gene transfer RNA proline (anticodon AGG) 48 Neighboring gene growth arrest and DNA-damage-inducible, beta Neighboring gene uncharacterized LOC134479806 Neighboring gene lamin B2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. GNG7 silencing promotes the proliferation and differentiation of placental cytotrophoblasts in preeclampsia rats through activation of the mTOR signaling pathway. Lai WS, et al. Int J Mol Med, 2019 May. PMID 30864685, Free PMC Article
    2. G-protein gamma 7 subunit is selectively expressed in medium-sized neurons and dendrites of the rat neostriatum. Watson JB, et al. J Neurosci Res, 1994 Sep 1. PMID 7807587
    3. Functional G-protein heterotrimers are associated with vesicles of putative glutamatergic terminals: implications for regulation of transmitter uptake. Pahner I, et al. Mol Cell Neurosci, 2003 Jul. PMID 12837624
    4. Loss of G protein gamma 7 alters behavior and reduces striatal alpha(olf) level and cAMP production. Schwindinger WF, et al. J Biol Chem, 2003 Feb 21. PMID 12488442
    5. Identification and characterization of the BRI2 interactome in the brain. Martins F, et al. Sci Rep, 2018 Feb 23. PMID 29476059, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. GNG7 silencing repressed apoptosis and enhanced the proliferation and differentiation of placental cytotrophoblasts in preeclampsia rats through activation of the mTOR signaling pathway.
      Title: GNG7 silencing promotes the proliferation and differentiation of placental cytotrophoblasts in preeclampsia rats through activation of the mTOR signaling pathway.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables G-protein beta-subunit binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within behavioral fear response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    acts_upstream_of_or_within locomotory behavior ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within receptor guanylyl cyclase signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of adenylate cyclase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Schaffer collateral - CA1 synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of heterotrimeric G-protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of heterotrimeric G-protein complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    is_active_in parallel fiber to Purkinje cell synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in synaptic vesicle membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7
    Names
    guanine nucleotide binding protein (G protein), gamma 7 subunit
    guanine nucleotide binding protein, gamma 7
    heterotrimeric guanine nucleotide-binding protein 3b

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_024138.1 → NP_077052.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7

      See identical proteins and their annotated locations for NP_077052.1

      Status: PROVISIONAL

      Source sequence(s)
      L23219
      UniProtKB/Swiss-Prot
      P43425, Q45QK4
      Conserved Domains (1) summary
      smart00224
      Location:8 → 69
      GGL; G protein gamma subunit-like motifs

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      9348148..9411924
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017595070.3 → XP_017450559.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 isoform X1

      UniProtKB/Swiss-Prot
      P43425, Q45QK4
      Conserved Domains (1) summary
      smart00224
      Location:8 → 69
      GGL; G protein gamma subunit-like motifs

    2. XM_039079813.2 → XP_038935741.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 isoform X1

      UniProtKB/Swiss-Prot
      P43425, Q45QK4
      Related
      ENSRNOP00000109030.1, ENSRNOT00000110558.2
      Conserved Domains (1) summary
      smart00224
      Location:8 → 69
      GGL; G protein gamma subunit-like motifs

    3. XM_039079814.2 → XP_038935742.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 isoform X1

      UniProtKB/Swiss-Prot
      P43425, Q45QK4
      Conserved Domains (1) summary
      smart00224
      Location:8 → 69
      GGL; G protein gamma subunit-like motifs

    4. XM_039079815.2 → XP_038935743.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 isoform X1

      UniProtKB/Swiss-Prot
      P43425, Q45QK4
      Conserved Domains (1) summary
      smart00224
      Location:8 → 69
      GGL; G protein gamma subunit-like motifs

    5. XM_039079812.2 → XP_038935740.1  guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-7 isoform X1

      UniProtKB/Swiss-Prot
      P43425, Q45QK4
      Conserved Domains (1) summary
      smart00224
      Location:8 → 69
      GGL; G protein gamma subunit-like motifs
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P43425.2 GenPept UniProtKB/Swiss-Prot:P43425

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